Memory Deficits Precede Increases in Depressive Symptoms in Later Adulthood

Aichele, Stephen; Ghisletta, Paolo

doi:10.1093/geronb/gbx183

Cited by 32 publications

(25 citation statements)

References 39 publications

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“…Until now, the few longitudinal studies to examine reciprocal lead-lag relations between cognition and depressive symptoms have primarily focused on memory deficits (Aichele & Ghisletta, 2018; Jajodia & Borders, 2011; Perrino et al, 2008). Apart from the difference in cognitive measures used (i.e., fluid intelligence vs. memory), the current results are consistent with these earlier studies in showing that cognitive deficits temporally precede increases in depressive symptoms in older adults.…”

Section: Discussionmentioning

confidence: 99%

“…We chose an alpha criterion of .01 for significance testing of changes in model fit and for parameter estimates. Although studies in the behavioral sciences typically select an alpha criterion of .05, it is not uncommon to find more conservative alpha criteria in population-based lifespan psychology studies, given their relatively large sample sizes (e.g., Aichele & Ghisletta, 2018; Jajodia & Borders, 2011). Selection of each model was guided by its Schwarz weight, that is, its weighted Bayesian information criterion, or w(BIC), rescaled as a relative probability of model preference, as explained by Wagenmakers and Farrell (2004).…”

Section: Methodsmentioning

confidence: 99%

“…This leaves three cognition-depression studies that applied lead-lag models to data across three or more time points. Results from these studies showed that lower cognitive performance preceded subsequent increases in depressive symptoms across 1-year intervals (Perrino et al, 2008) and 2-year intervals (Aichele & Ghisletta, 2018; Jajodia & Borders, 2011), whereas the converse did not hold.…”

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confidence: 95%

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Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936

et al. 2018

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We examined reciprocal, time-ordered associations between age-related changes in fluid intelligence and depressive symptoms. Participants were 1,091 community-dwelling older adults from the Lothian Birth Cohort 1936 study who were assessed repeatedly at 3-year intervals between the ages of 70 and 79 years. On average, fluid intelligence and depressive symptoms worsened with age. There was also a dynamic-coupling effect, in which low fluid intelligence at a given age predicted increasing depressive symptoms across the following 3-year interval, whereas the converse did not hold. Model comparisons showed that this coupling parameter significantly improved overall fit and had a correspondingly moderately strong effect size, accounting on average for an accumulated 0.9 standard-deviation increase in depressive symptoms, following lower cognitive performance, across the observed age range. Adjustment for sociodemographic and health-related covariates did not significantly attenuate this association. This implies that monitoring for cognitive decrements in later life may expedite interventions to reduce related increases in depression risk.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936

et al. 2018

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“…34 We adopted a step-by-step modelling strategy. [35][36][37] The fitted models included dynamic parameters: coupling and auto-proportional effects. BLCSM1 did not include crosslag paths between cognitive resources and physical activity and served as the baseline comparison model.…”

Section: Discussionmentioning

confidence: 99%

Age-related decline of cognitive resources precedes and explains the decline in physical activity

Cheval¹,

Orsholits²,

Sieber³

et al. 2018

Preprint

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Objective: This study aimed to test whether the level of cognitive resources explain the engagement in physical activity across aging and whether the age-related decline of cognitive resources precede the decline in physical activity. Methods: Data from 105,206 adults aged 50 to 90 years from the Survey of Health, Ageing and Retirement in Europe (SHARE) were used in adjusted linear mixed models to examine whether the engagement in moderate physical activity and its evolution across aging was dependent on cognitive resources. Cognitive resources and physical activity were measured 5 times over a 12-year period. Delayed recall, verbal fluency, and the level of education were used as indicators of cognitive resources. The frequency of engagement in moderate physical activity was self-reported. Dynamic structural equation models (SEM) were used to assess the temporal precedence of changes in cognitive resources and physical activity. Results: Results showed that lower cognitive resources were associated with lower levels and steeper decreases in moderate physical activity across aging. Results further revealed a time-ordered effect with a stronger influence of cognitive resources (delayed recall and verbal fluency) on subsequent changes in moderate physical activity than the opposite. Conclusion: These findings suggest that, after age 50, the level of engagement in moderate physical activity and its trajectory depend on the availability of cognitive resources.

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“…On the other hand, the Survey of Health Ageing and Retirement in Europe (SHARE) study has demonstrated that lower memory performance at a given age predicted subsequent 2-year increase in depressive symptoms. For each 1-point decrement on a 10-point memory scale there was a 14.5% increased risk of depression two years later [34]. These bidirectional relations may be due to a shared common pathogenic pathway that includes insulin resistance, persistent hyperglycaemia, repeated episodes of hypoglycaemia, mitochondrial dysfunction, oxidative stress, advanced glycation end products, reduced cerebral amyloid clearance, diabetes-related complications and vascular disease [35,36].…”

Section: Diabetes-cognition-mood Interactionmentioning

confidence: 99%

Management of Older People With Diabetes - A Focus On Mental Functions

Abdelhafiz¹

2020

OBM Geriatrics

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The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk factor and, at the same time, as a consequence of diabetes. To break the vicious circle of this complex reciprocal relationship between diabetes and mental dysfunction, early identification and treatment is important. Healthy lifestyle, appropriate glycaemic control, hypoglycaemia risk reduction and an organised and a holistic care is appropriate. Therefore, health care professionals involved in the care of older people with diabetes should be aware of this associated mental dysfunction and a collaborative care approach that includes integrated care of both physical and mental health is required.

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Memory Deficits Precede Increases in Depressive Symptoms in Later Adulthood

Abstract: In later adulthood, lower memory performance at a given age predicts subsequent 2-year increases in depressive symptoms.

Cited by 32 publications

References 39 publications

Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936

Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936

Age-related decline of cognitive resources precedes and explains the decline in physical activity

Management of Older People With Diabetes - A Focus On Mental Functions

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