Memory consolidation and expression of object recognition are susceptible to retroactive interference

Villar, María Eugenia; Martínez, María Cecilia; Cunha, Patricia Lopez da; Ballarini, Fabricio; Viola, Haydeé

doi:10.1016/j.nlm.2016.04.010

Cited by 18 publications

(21 citation statements)

References 52 publications

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“…In psychology, RI on forgetting is timing dependent and is most effective immediately after sampling or before testing [1]. In studies of rats [24] and mice (see Figures 2A-2D), it consistently shows that interference is also timing dependent. Interference exerts no impact on memory within the specific time window after sampling, such as at 2 hr and 8 hr for 4-hr and 24-hr recognition memory test, respectively (see Figures 2A and 2D), but leads to significant forgetting at hour 22 (see Figure 2A).…”

Section: Interference-induced Forgettingmentioning

confidence: 76%

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

Liu

et al. 2016

Current Biology

109

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Forgetting is a universal feature for most types of memories. The best-defined and extensively characterized behaviors that depict forgetting are natural memory decay and interference-based forgetting [1, 2]. Molecular mechanisms underlying the active forgetting remain to be determined for memories in vertebrates. Recent progress has begun to unravel such mechanisms underlying the active forgetting [3-11] that is induced through the behavior-dependent activation of intracellular signaling pathways. In Drosophila, training-induced activation of the small G protein Rac1 mediates natural memory decay and interference-based forgetting of aversive conditioning memory [3]. In mice, the activation of photoactivable-Rac1 in recently potentiated spines in a motor learning task erases the motor memory [12]. These lines of evidence prompted us to investigate a role for Rac1 in time-based natural memory decay and interference-based forgetting in mice. The inhibition of Rac1 activity in hippocampal neurons through targeted expression of a dominant-negative Rac1 form extended object recognition memory from less than 72 hr to over 72 hr, whereas Rac1 activation accelerated memory decay within 24 hr. Interference-induced forgetting of this memory was correlated with Rac1 activation and was completely blocked by inhibition of Rac1 activity. Electrophysiological recordings of long-term potentiation provided independent evidence that further supported a role for Rac1 activation in forgetting. Thus, Rac1-dependent forgetting is evolutionarily conserved from invertebrates to vertebrates.

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Section: Interference-induced Forgettingmentioning

confidence: 76%

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

Liu

et al. 2016

Current Biology

109

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“…Some studies support the idea that the HP is not necessary for formation and retrieval of the object recognition memory 28,41,[45][46][47][48][49] . Others, performed in tasks with strong object-context or object-object association suggest the contrary 26,39,[50][51][52][53][54] . These controversial findings about hippocampal-dependent object recognition memory may be explained by differences in behavioral task procedures, species used, and reversible vs. irreversible inactivation methods may explain those controversial findings 30 .…”

Section: Discussionmentioning

confidence: 98%

Anterior retrosplenial cortex is required for long-term object recognition memory

Landeta

Pereyra

Medina

et al. 2020

Sci Rep

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The retrosplenial cortex (RSC) is implicated on navigation and contextual memory. Lesions studies showed that the RSC shares functional similarities with the hippocampus (HP). Here we evaluated the role of the anterior RSc (aRSc) in the "what" and "where" components of recognition memory and contrasted it with that of the dorsal HP (dHP). Our behavioral and molecular findings show functional differences between the aRSC and the dHP in recognition memory. The inactivation of the aRSC, but not the dHP, impairs the consolidation and expression of the "what" memory component. In addition, object recognition task is accompanied by c-Fos levels increase in the aRSC. Interestingly, we found that the aRSC is recruited to process the "what" memory component only if it is active during acquisition. In contrast, both the aRSC and dHP are required for encoding the "where" component, which correlates with c-Fos levels increase. Our findings introduce a novel role of the aRSC in recognition memory, processing not only the "where", but also the "what" memory component. open Scientific RepoRtS | (2020) 10:4002 | https://doi.org/10.1038/s41598-020-60937-zwww.nature.com/scientificreports www.nature.com/scientificreports/ functions of the aRSC from those of the dHP, given that the last one is only required for the "where" component of recognition memory. ResultsaRSC, but not dHP, is required for the "what" memory component processing. To make a comparative study about the participation of aRSC and dHP in the "what" component of the recognition memory, we decided to study object recognition memory in the non-spatial Y-maze (Y-OR) task 28 . Due to the high walls, small corridors and the lack of explicit clues in the Y-maze, the Y-OR task has minimal spatial information and therefore a negligible "where" component. First, we validated the Y-OR task by transient inactivation of the PRh, confirming its requirement for object recognition memory ( Supplementary Fig. S1; p = 0.0031, t = 3.774, df = 11; Muscimol vs. Vehicle, Student's t test, n = 5-7). Then, we analyzed the participation of the aRSC and dHP in the formation of Y-OR long-term memory (LTM) by infusing the GABA A receptor agonist muscimol (0.1 μg/μl) or vehicle (saline) into the aRSC or the dHP immediately after the sample phase (training session), and we evaluated memory expression 24 h later during the choice phase (Fig. 1a). We found memory impairment associated to the Scientific RepoRtS | (2020) 10:4002 | https://doi.empty maze during 15 min for 2 days. Exposition time during sample and choice phases were the same as the Y-OR, with the difference that in this task the objects were located facing each other in the middle of the maze ( Supplementary Fig. S6B). Object Location. OL task was performed in the same apparatus that the SOR. This task was adapted fromEnnaceur and collaborators 37 . The habituation session consisted in letting the rat explore the empty apparatus during 20 min for 3 days. During the sample phase two identical objects were presented to the rat, each on...

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“…Finally, the BT hypothesis predicts that the tags set by different tasks localized in a common population of neurons could compete for capturing the available PRPs (Moncada et al, 2015). In that sense, retroactive interference was observed when an event was experienced after a strong learning task (Martínez, Alen, Ballarini, Moncada, & Viola, 2012;Martınez, Villar, Ballarini, & Viola, 2014;Villar et al, 2016). We suggest that this is the case for the impairing effect of the EP experienced 60 min post sSOR, which is compatible with the fact that a source of PRPs, like OF 60 min before sSOR, prevents this impairing effect.…”

Section: Discussionmentioning

confidence: 99%

“…Histological examination of the cannulas' placement was performed after the experiments by the infusion of 0.8 μL of 4% methylene blue in saline solution (Figure b). Animals were killed by decapitation 15 min after and their brains were removed and sliced to check the infusion area (maximum spread of about 1.5 mm 3 ) (Villar, Martinez, Lopes da Cunha, Ballarini, & Viola, ). Only data from animals with correct cannulas implants (95% of the rats) was included in statistical analyses.…”

Section: Methodsmentioning

confidence: 99%

Spatial object recognition memory formation under acute stress

et al. 2018

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Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short‐term memory (STM), promoted the formation of SOR‐long term memory (SOR‐LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid‐ and mineralocorticoid‐receptors, brain‐derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR‐LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis.

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Memory consolidation and expression of object recognition are susceptible to retroactive interference

Cited by 18 publications

References 52 publications

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

Anterior retrosplenial cortex is required for long-term object recognition memory

Spatial object recognition memory formation under acute stress

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