Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities

Jorm, Anthony F; Butterworth, Peter; Anstey, Kaarin J.; Christensen, Helen; Easteal, Simon; Maller, Jerome Joseph; Mather, Karen A.; Туракулов, Р. И.; Wang, Wen; Sachdev, Perminder S.

doi:10.1017/s0033291704003162

Cited by 178 publications

(207 citation statements)

References 38 publications

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“…The relationship with objective cognitive performance on neuropsychological assessment is unclear. Although most studies showed no relationship with objective cognitive impairment when corrected for mood and health, [1][2][3][4][5][6] some studies reported positive associations. 7,8 However, studies have shown a strong association with poor physical health 6 and depression.…”

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confidence: 94%

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

et al. 2014

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Subjective cognitive failures (SCF) are a common feature in elderly people with cardiovascular disease.1 SCF are personal experiences of cognitive problems in everyday life, such as difficulties in memory (eg, forgetfulness), information processing speed (eg, slowness in performing simple tasks), and executive function (eg, problems in planning or reasoning). Although these subjective problems are common, it is not completely clear what they represent. The relationship with objective cognitive performance on neuropsychological assessment is unclear. Although most studies showed no relationship with objective cognitive impairment when corrected for mood and health, 1-6 some studies reported positive associations. 7,8 However, studies have shown a strong association with poor physical health 6 and depression. 2,6Research on SCF in patients with hypertension is scarce, despite the increasing support for an association between hypertension and objective cognitive impairment, 9-11 which might be because of brain damage. Hypertension is a major risk factor for white matter hyperintensities (WMH) 12 and other magnetic resonance imaging (MRI) manifestations of cerebral small vessel disease (cSVD), 13 which include lacunes, cerebral microbleeds, and perivascular spaces.14 A possible association between SCF and cSVD-related brain damage, as proposed by previous research, 1,15,16 and objective cognitive impairment has not been examined before in patients with hypertension.Patients with hypertension expressing SCF may be a recognizable situation for clinicians. To gain more knowledge about the implications of SCF in patients with hypertension, this study investigated whether SCF are associated with objective cognitive impairment, independent of confounding factors, such as age, sex, symptoms of anxiety and depression, and vascular risk factors. In addition, we examined whether SCF are predictive for the presence of MRI markers of cSVD.Abstract-Previous studies on the relationship between subjective cognitive failures (SCF) and objective cognitive function have shown inconsistent results. In addition, research on the association between SCF and imaging markers of cerebral small vessel disease is limited. We investigated whether SCF in patients with essential hypertension, who are at high risk of cerebral small vessel disease, are associated with objective cognitive function and magnetic resonance imaging manifestations of cerebral small vessel disease. We included 109 patients with hypertension who underwent extensive neuropsychological assessment, including questionnaires measuring SCF and symptoms of anxiety and depression. Brain magnetic resonance imaging was performed to rate the presence of lacunes, cerebral microbleeds, and perivascular spaces, as well as white matter hyperintensities volume. Results showed significant associations between SCF and objectively measured overall cognition (B=−0.02; 95% confidence interval=−0.03 to −0.005), memory (B=0.02; 95% confidence interval=−0.03 to −0.004), and information processin...

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confidence: 94%

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

et al. 2014

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“…However, in community-based samples, a significant relationship was observed between selfreported memory problems and poor memory performance independently of depressive symptomatology . Apart from the depression, the SMC have also been related to anxiety and personality traits (Jorm et al 2004). However, there is also growing evidence to suggest that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease (Rodda et al 2009).…”

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confidence: 99%

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

Bajo

Castellanos

López

et al. 2011

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It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.

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“…Ensuite, dans une étude sur une vaste population de personnes âgées avec plainte mnésique sans égard à la forme ou sans plainte mnésique, aucune différence n'a été constatée en ce qui concerne la présence de facteurs de risques biologiques pour le développement d'une démence, malgré l'utilisation de diverses méthodes d'analyses (p. ex., l'analyse de l'apolipoprotéine de type E, l'analyse du volume des hippocampes, l'analyse du volume des amygdales et l'analyse du volume de la matière blanche) (Jorm et al, 2004). Par contre, les personnes ayant des plaintes mnésiques avaient généralement plus d'affects négatifs, une moins bonne santé physique et une prévalence à la dépression et à l'anxiété plus élevée que ceux n'ayant pas de plaintes cognitives (Jorm et al, 2004 Une fois la dépression traitée efficacement, les déficits cognitifs s'estompent.…”

Section: Historique Et éVolution Du Concept Des Altérations Cognitiveunclassified

“…ex., l'analyse de l'apolipoprotéine de type E, l'analyse du volume des hippocampes, l'analyse du volume des amygdales et l'analyse du volume de la matière blanche) (Jorm et al, 2004). Par contre, les personnes ayant des plaintes mnésiques avaient généralement plus d'affects négatifs, une moins bonne santé physique et une prévalence à la dépression et à l'anxiété plus élevée que ceux n'ayant pas de plaintes cognitives (Jorm et al, 2004 Une fois la dépression traitée efficacement, les déficits cognitifs s'estompent.…”

Section: Historique Et éVolution Du Concept Des Altérations Cognitiveunclassified

Évaluation de l'implication de la mémoire de travail sur des tâches de «théorie de l'esprit» chez la personne âgée avec altération cognitive légère /

Lavoie¹

2013

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Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities

Abstract: In a community sample aged 60-64 years, memory complaints were most closely related to psychiatric symptoms, personality characteristics and poor physical health. There was no evidence of brain changes indicating early dementia.

Cited by 178 publications

References 38 publications

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

Évaluation de l'implication de la mémoire de travail sur des tâches de «théorie de l'esprit» chez la personne âgée avec altération cognitive légère /

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