Memory CD8<sup>+</sup> T cell compartment associated with delayed onset of <i>Plasmodium falciparum</i> infection and better parasite control in sickle‐cell trait children

Loiseau, Claire; Traoré, Boubacar; Ongoïba, Aïssata; Kayentao, Kassoum; Doumbo, Safiatou; Doumtabé, Didier; Sousa, Karina Pires de; Brady, Jamie L.; Proietti, Carla; Crompton, Peter D.; Doolan, Denise L.

doi:10.1002/cti2.1265

Clin & Trans Imm

2021

DOI: 10.1002/cti2.1265

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Memory CD8⁺ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children

Claire Loiseau

Boubacar Traoré

Aïssata Ongoïba

et al.

Abstract: Memory CD8 + T cells and sickle-cell trait children C Loiseau et al.

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Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Oleinikov,

Seidu,

Oleinikov

et al. 2023

The Journal of Infectious Diseases

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Protective immunity to malaria is mainly antibody-mediated and members of the PfEMP1 family are important targets. Abnormal display of PfEMP1 on the infected erythrocytes (IEs) surface and reduced cytoadhesion have been demonstrated in HbAS and HbAC, inherited blood disorders associated with protection against severe P. falciparum malaria. We found that Ghanaian children with HbAS had lower levels of IgG specific for several PfEMP1 variants and that this reactivity increased more slowly with age than in their HbAA counterparts. Moreover, children with HbAS have lower total parasite biomass than those with HbAA at comparable peripheral parasitemias, suggesting impaired cytoadhesion of HbAS IEs in vivo and likely explaining the slower acquisition of PfEMP1-specific IgG in this group. In contrast, the function of acquired antibodies was comparable among Hb groups and appears to be intact and sufficient to control parasitemia via opsonization and phagocytosis of IEs.

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Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Oleinikov,

Seidu,

Oleinikov

et al. 2023

The Journal of Infectious Diseases

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show abstract

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Memory CD8⁺ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children

Abstract: Memory CD8 + T cells and sickle-cell trait children C Loiseau et al.

Cited by 1 publication

References 42 publications

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

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Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children

Abstract: Memory CD8 + T cells and sickle-cell trait children C Loiseau et al.

Cited by 1 publication

References 42 publications

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

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Memory CD8⁺ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children