Memory-boosting devices tested in humans

Reardon, Sara

doi:10.1038/527015a

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the lesser effect in the better-designed studies, transplantation of bone marrow-derived mesenchymal stem cells did consistently ameliorate Aβ-induced neurotoxicity and cognitive decline in vivo and in vitro. It inhibited apoptotic cell death and oxidative stress in the hippocampus 9 .…”

Section: Preventing Memory Decline In Neurodegenerative Diseasementioning

confidence: 94%

“…Thereby, as shown in the paper, functional working memory of the recipient rats could be improved 104 . Now, two research groups are testing realtime brain stimulation through implanted electrodes in humans 9,105,106 . The first positive results suggest that this cutting-edge development could one day help individuals following brain trauma or head injuries to transfer information from short-term into long-term memory as well as considerably increase retrieval performance 9,105,106 .…”

Section: Augmented Reality and Chip Devices To Boost Memorymentioning

confidence: 99%

“…Now, two research groups are testing realtime brain stimulation through implanted electrodes in humans 9,105,106 . The first positive results suggest that this cutting-edge development could one day help individuals following brain trauma or head injuries to transfer information from short-term into long-term memory as well as considerably increase retrieval performance 9,105,106 . The key is to derive a nonlinear multiinput, multi-output model of hippocampal CA3 and CA1 neural firing.…”

Section: Augmented Reality and Chip Devices To Boost Memorymentioning

confidence: 99%

“…We compare the approaches regarding memoryenhancing effects, briefly describe their physiological background and critically reexamine the prevailing limitations. Regarding the future, we discuss the recovery of memories through light stimulation 5 and potential memory prostheses 9 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Delaying memory decline: different options and emerging solutions

et al. 2020

View full text Add to dashboard Cite

Memory decline can be a devastating disease and increases in aging Western populations. Memory enhancement technologies hold promise for this and other conditions. Approaches include stem cell transplantation, which improved memory in several animal studies as well as vaccination against Alzheimer´s disease (AD) by β-amyloid antibodies. For a positive clinical effect, the vaccine should probably be administered over a long period of time and before amyloid pathologies manifest in the brain. Different drugs, such as erythropoietin or antiplatelet therapy, improve memory in neuropsychiatric diseases or AD or at least in animal studies. Omega-3 polyunsaturated fatty acid-rich diets improve memory through the gut–brain axis by altering the gut flora through probiotics. Sports, dancing, and memory techniques (e.g., Method of Loci) utilize behavioral approaches for memory enhancement, and were effective in several studies. Augmented reality (AR) is an auspicious way for enhancing memory in real time. Future approaches may include memory prosthesis for head-injured patients and light therapy for restoring memory in AD. Memory enhancement in humans in health and disease holds big promises for the future. Memory training helps only in mild or no impairment. Clinical application requires further investigation.

show abstract

Section: Preventing Memory Decline In Neurodegenerative Diseasementioning

confidence: 94%

Section: Augmented Reality and Chip Devices To Boost Memorymentioning

confidence: 99%

Section: Augmented Reality and Chip Devices To Boost Memorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Delaying memory decline: different options and emerging solutions

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Implantable electrodes provide an efficient means for designing innovative therapeutic approaches, and electroactive devices have been deeply investigated during the past decades. − For example, the monitoring of drugs has been proposed to more precisely adjust the drug dosage according to the pharmacokinetic profiles and a precise quantification of drug concentration after administration . Electroanalytical techniques have been found to be efficient for monitoring drugs in different biological fluids. , Cyclic voltammetry techniques have been used to follow several drugs, including analgesics, antibiotics, antipsychotic and hypoglycaemics .…”

Section: Introductionmentioning

confidence: 99%

Low-Molecular-Weight Hydrogels as New Supramolecular Materials for Bioelectrochemical Interfaces

Jain

Karajić

Murawska

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Controlling the interface between biological tissues and electrodes remains an important challenge for the development of implantable devices in terms of electroactivity, biocompatibility, and long-term stability. To engineer such a biocompatible interface a low molecular weight gel (LMWG) based on a glycosylated nucleoside fluorocarbon amphiphile (GNF) was employed for the first time to wrap gold electrodes via a noncovalent anchoring strategy, that is, self-assembly of GNF at the electrode surface. Scanning electron microscopy (SEM) studies indicate that the gold surface is coated with the GNF hydrogels. Electrochemical measurements using cyclic voltammetry (CV) clearly show that the electrode properties are not affected by the presence of the hydrogel. This coating layer of 1 to 2 μm does not significantly slow down the mass transport through the hydrogel. Voltammetry experiments with gel coated macroporous enzyme electrodes reveal that during continuous use their current is improved by 100% compared to the noncoated electrode. This demonstrates that the supramolecular hydrogel dramatically increases the stability of the bioelectrochemical interface. Therefore, such hybrid electrodes are promising candidates that will both offer the biocompatibility and stability needed for the development of more efficient biosensors and biofuel cells.

show abstract