Memory B Cell Responses at 16 Weeks Following a Single Dose of AZD1222/Covishield in Sri Lankan Individuals

Ramu, Shwetha; Jeewandara, Chandima; Kuruppu, H.; Pushpakumara, P. G. A.; Harvie, Michelle; Dayarathna, Shashika; Jayadas, T.; Ranasinghe, Tamra; Aberathna, I.S.; Danasekara, Saubhagya; Dissanayake, Oshani; Gamalath, N.; Ekanayake, S.; Jayamali, J.; Guruge, D.; Wijayamuni, Ruwan; Ogg, Graham S.; Malavige, N.

doi:10.1016/j.ijid.2021.12.148

Cited by 1 publication

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“…73 Another study by Ramu ST et al on 45 participants demonstrated that around 86.7%-88.9% of individuals have a potent memory B cell response against the Spike glycoprotein of SARS-CoV-2 instigated by a single dose of vaccine. 74 The selection and proliferation of RBD-specific B cells are encouraged by follicular T helper cells. 75,76 Moreover, a study by Foster et al reported that Covishield-induced humoral immune responses necessitate germinal centre (GC) activation that exhibits the selection and expansion of antigen-specific cells.…”

Section: Replication-defective Viral Vector Vaccinementioning

confidence: 99%

“…Another study by Ramu ST et al. on 45 participants demonstrated that around 86.7%–88.9% of individuals have a potent memory B cell response against the Spike glycoprotein of SARS‐CoV‐2 instigated by a single dose of vaccine 74 . The selection and proliferation of RBD‐specific B cells are encouraged by follicular T helper cells 75,76 .…”

Section: Generation Of B Cell Response By Different Vaccinesmentioning

confidence: 99%

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To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals

Ahmed,

Athavale,

Tripathi

et al. 2023

Scand J Immunol

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COVID‐19 disease has plagued the world economy and affected the overall well‐being and life of most of the people. Natural infection as well as vaccination leads to the development of an immune response against the pathogen. This involves the production of antibodies, which can neutralize the virus during future challenges. In addition, the development of cellular immune memory with memory B and T cells provides long‐lasting protection. The longevity of the immune response has been a subject of intensive research in this field. The extent of immunity conferred by different forms of vaccination or natural infections remained debatable for long. Hence, understanding the effectiveness of these responses among different groups of people can assist government organizations in making informed policy decisions. In this article, based on the publicly available data, we have reviewed the memory response generated by some of the vaccines against SARS‐CoV‐2 and its variants, particularly B cell memory in different groups of individuals.

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