Memory and psychomotor impairment following high-dose interferon treatment in amyotrophic lateral sclerosis

Iivanainen, Matti; Laaksonen, Ritva; Niemi, Marianna; Färkkilä, Markus; Bergström, Lea; Mattson, K.; Niiranen, A.; Cantell, Kari

doi:10.1111/j.1600-0404.1985.tb00904.x

Cited by 55 publications

(7 citation statements)

References 13 publications

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“…Of interest, the information that is encoded into a memory representation is biased by selective attention, and this bias is mediated by cortical-hippocampal interactions (Uncapher & Rugg, 2009). To our knowledge, the present study is the first attempt to precisely explain ALS memory difficulties through impaired selective attention and/or inhibitory control, despite the fact that it was since 1985, that Iivanainen and colleagues noted that ''another underlying possible mechanism is the increased inhibition or interference of memory traces due to interfering actions both in recall and other memorizing structures as seen in the subcortex and brain stem lesions'' (Iivanainen et al, 1985).…”

Section: Selective Attention As a ''Gatekeeper'' To Memory And The Comentioning

confidence: 71%

Selective Attention and the Three-Process Memory Model for the Interpretation of Verbal Free Recall in Amyotrophic Lateral Sclerosis

Christidi

Zalonis

Smyrnis

et al. 2012

J Int Neuropsychol Soc

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The present study investigates selective attention and verbal free recall in amyotrophic lateral sclerosis (ALS) and examines the contribution of selective attention, encoding, consolidation, and retrieval memory processes to patients' verbal free recall. We examined 22 non-demented patients with sporadic ALS and 22 demographically related controls using Stroop Neuropsychological Screening Test (SNST; selective attention) and Rey Auditory Verbal Learning Test (RAVLT; immediate & delayed verbal free recall). The item-specific deficit approach (ISDA) was applied to RAVLT to evaluate encoding, consolidation, and retrieval difficulties. ALS patients performed worse than controls on SNST (p < .001) and RAVLT immediate and delayed recall (p < .001) and showed deficient encoding (p = .001) and consolidation (p = .002) but not retrieval (p = .405). Hierarchical regression analysis revealed that SNST and ISDA indices accounted for: (a) 91.1% of the variance in RAVLT immediate recall, with encoding (p = .016), consolidation (p < .001), and retrieval (p = .032) significantly contributing to the overall model and the SNST alone accounting for 41.6%; and (b) 85.2% of the variance in RAVLT delayed recall, with consolidation (p < .001) and retrieval (p = .008) significantly contributing to the overall model and the SNST alone accounting for 39.8%. Thus, selective attention, encoding, and consolidation, and to a lesser extent of retrieval, influenced both immediate and delayed verbal free recall. Concluding, selective attention and the memory processes of encoding, consolidation, and retrieval should be considered while interpreting patients' impaired free recall. (JINS, 2012, 18, 1-10).

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Section: Selective Attention As a ''Gatekeeper'' To Memory And The Comentioning

confidence: 71%

Selective Attention and the Three-Process Memory Model for the Interpretation of Verbal Free Recall in Amyotrophic Lateral Sclerosis

Christidi

Zalonis

Smyrnis

et al. 2012

J Int Neuropsychol Soc

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“…Additionally, micrographia has been found to have a high positive likelihood ratio4 5 of being associated with an accurate diagnosis of PD. The phenomenon of micrographia is not restricted to PD but has been reported in Huntington's disease,6 amyotrophic lateral sclerosis7 and lupus8 conditions; however, these studies lack adequate number of patients to draw any conclusion on the specificity of the symptom.…”

Section: Introductionmentioning

confidence: 99%

Micrographia and related deficits in Parkinson's disease: a cross-sectional study

et al. 2012

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ObjectivesTo determine the prevalence and clinical features associated with micrographia in Parkinson's Disease (PD).SettingThis study was conducted at a Movement Disorders clinic located in a Veteran Administration Hospital.ParticipantsPD subjects were included only if they satisfied UK Parkinson's Disease Society criteria for diagnosis. Subjects with history of severe tremors, dystonia, dyskinesia, strokes, peripheral neuropathy and dementia were excluded.DesignThis was a case–control study where PD subjects were prospectively enrolled and their demographics, Hoehn & Yahr stage, Unified Parkinson's Disease Rating Scale and Mini Mental Status examination (MMSE) scores were recorded. All subjects were specifically asked for micrographia on history and the handwritings were quantitatively documented. Bradykinesia was determined by history and quantified by a finger tap, Purdue pegboard and a timed walk test. Similarly, hypophonia was determined by history and the volume of speech quantified using a decibel meter. Controls were enrolled for validation of handwriting test scores and decibel meter recordings.Primary outcome measuresPrevalence of micrographia in the PD cohort and the clinical factors that correlate with micrographia.Results68 subjects with PD were enrolled (68 men; mean age 72.3 years). Micrographia was identified in 63.2% of the cohort on verbal history and in 50% of the cohort when the handwriting test was used for ascertainment. Micrographia ascertained on history correlated significantly with disease severity (Hoehn & Yahr stage), motor impairment (Unified Parkinson's Disease Rating Scale), cognitive impairment (MMSE) and both bradykinesia and hypophonia determined by history and quantitative testing. Micrographia on handwriting test correlated with age (p=0.02), MMSE testing (p=0.04), hypophonia by history (p=0.01) and bradykinesia by quantitative testing (p=0.04).ConclusionMicrographia was found in nearly half of the PD cohort. Disease severity and impaired cognition were important clinical correlates. Micrographia had a significant relationship with bradykinesia and hypophonia, suggesting a possible overlap in their pathophysiology.

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“…EEG is a minimally invasive method to assess brain activity. Previous studies on spontaneous EEG have reported some IFN-α induced alterations, such as enhanced slow-wave activity ( Iivanainen et al, 1985) and increased synchronization (Birmanns et al, 1990). Recently, gamma band oscillations in EEG have become a subject of increasing research interest.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Auditory Steady-State Response of Awake Mice Induced by Chronic Interferon-α Treatment

Wang

Chen

et al. 2021

Front. Pharmacol.

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Background: Patients receiving the cytokine immunotherapy of interferon-alpha (IFN-α) frequently present with depression. This is one of the excellent models to explore the action of peripheral cytokine on central nervous system (CNS) and to study the development of depression. The auditory steady-state response (ASSR), electroencephalogram (EEG) oscillations induced by periodic acoustic stimulation, is an effective approach to evaluate the neural function in mental illness including depression. The aim of the present study was to investigate the effect of IFN-α on the cortical ASSR and its correlation with depressive-like behavior.Methods: Chronic electrodes were implanted on the skull over the auditory cortex (AC) of male C57BL/6 mice. The animals were treated with daily injection of IFN-α or saline (vehicle) for three weeks. EEGs were recorded in AC of the same mouse before and after the injection treatment to monitor the changes of ASSR induced by IFN-α. Depressive-like behavior was analyzed in the forced swim test (FST). Immunohistochemical staining was used to examine the status of neuron and glia in the hippocampus and AC.Results: Compared to pretreatment condition, injection of IFN-α significantly reduced the power of 40 Hz ASSR in the mouse AC from the second week. Such a decrease continued to the third week. The immobility times of FST were significantly increased by a 3-week treatment of IFN-α and the immobility time was negatively correlated with the power of 40 Hz ASSR. Astrocytes and microglia in the hippocampus and AC were activated by IFN-α, but the density of neuron was not significantly affected.Conclusion: Our results suggest that EEG measurement of ASSR may be used as a biomarker to monitor the CNS side effects of IFN-α treatment and to search a novel intervention with potential therapeutic implications.

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Memory and psychomotor impairment following high-dose interferon treatment in amyotrophic lateral sclerosis

Cited by 55 publications

References 13 publications

Selective Attention and the Three-Process Memory Model for the Interpretation of Verbal Free Recall in Amyotrophic Lateral Sclerosis

Selective Attention and the Three-Process Memory Model for the Interpretation of Verbal Free Recall in Amyotrophic Lateral Sclerosis

Micrographia and related deficits in Parkinson's disease: a cross-sectional study

Aberrant Auditory Steady-State Response of Awake Mice Induced by Chronic Interferon-α Treatment

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