Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

Kallio, Jukka; Hirvikoski, Pasi; Kellokumpu-Lehtinen, P.; Helin, H; Tammela, T.L.J.; Martikainen, Petri

doi:10.1016/s1569-9056(03)80539-0

Cited by 14 publications

(19 citation statements)

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“…In this paper, the authors have reported that overall survival was significantly longer (P ¼ 0.004) in patients with prominent membranous EGFR expression compared to patients with either EGFR-negative tumours or tumours with predominantly cytoplasmic EGFR staining (Kallio et al, 2003). This is an important finding, as the expression of membranous EGFR has often been associated with a poor prognosis in cancer patients (Lager et al, 1994;Moch et al, 1997), while other studies have found either no association between EGFR expression and prognosis (Hofmockel et al, 1997) or more recently an association between the expression of cytoplasmic EGFR and poor prognosis in RCC patients (Langner et al, 2004).…”

Section: Sirmentioning

confidence: 81%

“…We read with great interest the published article by Kallio et al (2003) in the British Journal of Cancer on the association between the location of EGFR immunostaining and overall survival in renal cell carcinoma (RCC) patients. In this paper, the authors have reported that overall survival was significantly longer (P ¼ 0.004) in patients with prominent membranous EGFR expression compared to patients with either EGFR-negative tumours or tumours with predominantly cytoplasmic EGFR staining (Kallio et al, 2003).…”

Section: Sirmentioning

confidence: 99%

See 1 more Smart Citation

Is membranous location of EGFR or EGFRvIII immunostaining associated with good prognosis in renal cell carcinoma?

Modjtahedi

Cunningham

2005

Br J Cancer

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Section: Sirmentioning

confidence: 81%

Section: Sirmentioning

confidence: 99%

Is membranous location of EGFR or EGFRvIII immunostaining associated with good prognosis in renal cell carcinoma?

Modjtahedi

Cunningham

2005

Br J Cancer

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“…Accordingly, RCC patients with positive membranous EGFR expression may have a poorer survival outcome when compared with those with negative expression of membranous EGFR (Pu et al, 2009). However, a previous study casts doubt on this hypothesis (Kallio et al, 2003).…”

Section: Transforming Growth Factor- and Epidermal Growth Factor Recmentioning

confidence: 94%

The VHL-HIF Signaling in Renal Cell Carcinoma: Promises and Pitfalls

Morais¹,

Johnson²,

Gobé³

2012

Emerging Research and Treatments in Renal Cell Carcinoma

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“…Abnormal expression of EGFR has been reported to be associated with a large number of human malignancies such as glioma, lung cancer, and colon cancer (4,5). However, the correlation between EGFR expression and prognosis of patients with cancer still remains elusive (6)(7)(8)(9). In addition, although EGFR is a validated cancer therapeutic target, the clinical responses to EGFR inhibitors are limited (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells

et al. 2013

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As a validated therapeutic target in several human cancers, the EGF receptor (EGFR) provides a focus to gain deeper insights into cancer pathophysiology. In this study, we report the identification of a naturally occurring and widely expressed EGFR isoform termed EGFRvA, which substitutes a Ser/Thr-rich peptide for part of the carboxyl-terminal regulatory domain of the receptor. Intriguingly, EGFRvA expression relates more closely to histopathologic grade and poor prognosis in patients with glioma. Ectopic expression of EGFRvA in cancer cells conferred a higher invasive capacity than EGFR in vitro and in vivo. Mechanistically, EGFRvA stimulated expression of STAT3, which upregulated heparin-binding EGF (HB-EGF). Reciprocally, HB-EGF stimulated phosphorylation of EGFRvA at Y845 along with STAT3, generating a positive feedback loop that may reinforce invasive function. The significance of EGFRvA expression was reinforced by findings that it is attenuated by miR-542-5p, a microRNA that is a known tumor suppressor. Taken together, our findings define this newfound EGFR isoform as a key theranostic molecule. Cancer Res; 73(23); 7056-67. Ó2013 AACR.

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Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

Cited by 14 publications

References 0 publications

Is membranous location of EGFR or EGFRvIII immunostaining associated with good prognosis in renal cell carcinoma?

Is membranous location of EGFR or EGFRvIII immunostaining associated with good prognosis in renal cell carcinoma?

The VHL-HIF Signaling in Renal Cell Carcinoma: Promises and Pitfalls

A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells

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