Membranous glomerulonephritis secondary to hydatid disease

Ibarrola, A. Sánchez; Sobrini, B.; Guisantes, Jorge A.; Pardo, Julián; Diez, Jordana Sales; Monfá, José M.; Purroy, Ana

doi:10.1016/0002-9343(81)90766-x

Cited by 31 publications

(6 citation statements)

References 15 publications

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“…The nuclei either became hypertrophic or pyknotic. All these changes may be due to proteinuria as reported by Ozeretskovskaya et al (1978), Vialtel et al (1981) and Ibarrola et al (1981). The enzymes and toxins present in HFCF crossed the glomerular membrane and affected the cells lining all the tubules, collecting ducts and the loops of Henle thereby causing necrosis in them.…”

Section: Discussionmentioning

confidence: 69%

Echinococcus Granulosus: A Morphometric and Histopathological Response of Kidney in Rabbits

Akhtar¹,

Qadir²,

Anwar³

et al. 1998

Pakistan J. of Biological Sciences

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Out of forty rabbits (Lepus nigricollis) acclimatized to the optimal condition of animal house, thirty-five were daily inoculated with weekly increasing doses of filtered hydatid cyst fluid of sheep origin for seven weeks. 15 control rabbits were given similar doses of distilled water. Five experimental and three control rabbits were weekly slaughtered and their kidney tissue was fixed in bouins and stained with haematoxylin and eosine. The morphometric findings made and compared with their respective controls, showed significant increase (p<0.001) in the area and volume of glomerules. In the histological preparations of kidney of infected rabbits capillaries of the glomeruli, loops of Henle and lumen of collecting tubules was found dilated. The space between the Bowman's capsule diminished while'in some it increased due to the shrinkage of the glomerular capillaries. In the proximal and distal tubules the cell membranes towards the lumen were destroyed while those away from it were diffused. The cells were hypertrophied with colloidal disintegration, vacuolation and in some cases margination. The nuclei were either hypertrophied with vacuolation or pyknotic and darkly stained. The arteries were thick walled and surrounded by fibrotic tissues while the veins were full of red blood cells. Hemorrhage was present in different regions. There was an overall infiltration of leukocytes. It was noted that the damage in the kidney tissues increased with the increase in dose and time.

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Section: Discussionmentioning

confidence: 69%

Echinococcus Granulosus: A Morphometric and Histopathological Response of Kidney in Rabbits

Akhtar¹,

Qadir²,

Anwar³

et al. 1998

Pakistan J. of Biological Sciences

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“…[5] glomerüllerde ekinokok antijen ve antikorlarını saptayarak ikincil böbrek hasarının gelişiminde immunkompleks oluşumunun rolünü göstermişlerdir. Karaciğer kist hidatik hastalığı sonrası membranöz glomerülopati [6], mezangioroliferatif glomerülonefrit [7], minimal lezyon hastalığı [8] ve akut postinfeksiyoz glomerülonefrit [9] gelişen hastalar daha önce bildirilmiştir. Sürekli ekinokok antijen sunumuna karşı gelişen antikor yanıtı ile glomerül bazal membranda antijen-antikor birikimi gelişebilir.…”

Section: Discussionunclassified

Karaciğer kist hidatik hastalığı sonrası gelişen tübülointerstisiel nefrite ikincil akut böbrek hasarı

Candan¹

2019

Pamukkale Medical Journal

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ÖzetRenal hidatik hastalık literatürde iyi tanımlanmıştır ve pekçok çalışma mevcuttur. Bununla birlikte doğrudan invazyon olmaksızın böbrek hasarı gelişimi oldukça nadir bir durumdur. Bu sunumda hepatik kist hidatiği olan hastada tubulointerstisyel nefrite ikincil akut böbrek hasarı gelişen bir vaka bildirilmiştir. Hasta albendazol ve perkütan aspirasyon injeksiyon ve reaspirasyon girişimi ile tedavi edilmiştir. Halen oral albendazol tedavisi ile izlenen hastanın bulguları izlemde düzelmiştir.Anahtar Kelimeler: Ekinokok, hidatik kist, akut böbrek hasarı, tübülointerstisyel nefrit.Candan C, Canizci Erdemli P, Turhan P. Karaciğer kist hidatik hastalığı sonrası gelişen tübülointerstisyel nefrite ikincil akut böbrek hasarı. Pam Tıp Derg 2019;12:581-584. AbstractRenal hydatid disease is well defined, and many studies are present in the literature. Howewer, renal injury without direct renal invasion is a less well-known subject. Here is the report of a patient with hepatic hydatid cyst who presented with acute renal failure secondary to tubulointerstitial nephritis. The patient was treated with the combination of albendazole, and percutaneous aspiration, injection, and re-aspiration therapy. The patient is now on oral albendazole therapy and doing well on follow-up.

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“…The last two factors could explain the difference between our results and those reported elsewhere. In fact, Vialtel et al (1981) and Ibarrola et al (1981), based on observations of a single patient in each case and using a rabbit antiserum in indirect immunofluorescence, found evidence of specific IC in the kidney of patients with membranous nephropathy and hydatidosis. (4) Lastly, we cannot rule out the possibility of a B-cell polyclonal activation, with a consequent appearance of CIC formed of auto-and/or hetero-antigens, different from parasitic antigens and corresponding antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…The level of CIC seems to correlate with the clinical course of the disease better than that of specific antibodies (D'Amelio et al 1983). Patients with hydatid disease do not normally present with serum sickness-like symptomatology, although membranous nephropathy has recently been reported in patients with hydatidosis (Vialtel et al 1981;Ibarrola et al 1981), with detection of parasitic antigens in renal glomeruli by indirect immunofluorescence.…”

Section: Introductionmentioning

confidence: 99%

Hydatid disease: analysis of parasite antigens in circulating immune complexes and in preformed hydatid antigen-antibody complexes

D’Amelio¹,

Rosa

Pontesilli

et al. 1989

Med Microbiol Immunol

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Fifty-three sera from 29 patients with hydatid disease, all but one positive for specific anti-parasite antibodies and all negative for specific circulating antigens, were studied for the presence of circulating immune complexes (CIC) by conglutinin binding-assay (KgBA). Fourteen serum samples (26%) from eight patients (27%) were positive. These positive sera were pooled for each patient and the eight samples were PEG-precipitated and analysed for the presence of specific Echinococcus granulosus antigens in the CIC using a human anti-human-hydatid cyst fluid antiserum capable of recognizing the major antigenic systems of the parasite namely, antigens 4 and 5. The assays utilized for detecting antigen in CIC were: (a) blotting on nitrocellulose paper after sodium dodecil sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and specific immunological detection; (b) ultracentrifugation in acid buffer and subsequent detection of antigens by a sandwich-radioimmuno assay (RIA); (c) protein separation by isoelectric focusing (IEF) and specific immunological recognition. In addition, all positive sera were analysed for the presence of antigen in the CIC by a modified KgBA and by polyethylenglicol (PEG)-precipitation in acid buffer followed by immunological recognition of antigen. All tests gave negative results with the patients' samples, but were positive with preformed in vitro complexes between parasite antigens and corresponding antibodies. Failure to detect antigen in the CIC could be due to: 1) insufficient sensitivity of the assays used to detect hydatid antigens in CIC; 2) rapid clearance of antigen or CIC from the circulation; 3) presence of parasite antigen not recognized by the antiserum employed; 4) production of CIC as a result of polyclonal B-cell activation. This last hypothesis is supported by the demonstration of IgM-rheumatoid factor (RF) and anti-F(ab')2 antibodies respectively in 11 (44%) and 13 (52%) out of 25 patients.

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Membranous glomerulonephritis secondary to hydatid disease

Cited by 31 publications

References 15 publications

Echinococcus Granulosus: A Morphometric and Histopathological Response of Kidney in Rabbits

Echinococcus Granulosus: A Morphometric and Histopathological Response of Kidney in Rabbits

Karaciğer kist hidatik hastalığı sonrası gelişen tübülointerstisiel nefrite ikincil akut böbrek hasarı

Hydatid disease: analysis of parasite antigens in circulating immune complexes and in preformed hydatid antigen-antibody complexes

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