Membranotropic properties of fullerene-containing amphiphilic (co)polymers of N-vinylpyrrolidone

Faingold, I. I.; Lozhkin, A. D.; Smolina, A. V.; Soldatova, Yu. V.; Obraztsova, N. A.; Kurmaz, S. V.; Романова, В. С.; Shtol’ko, V. N.; Kotelnikova, R. A.

doi:10.1007/s11172-018-2140-5

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“…77 nm due to their self-assembly [ 58 ]. The CAC values were obtained from the DLS data using the semilogarithmic dependence of light scattering intensity on the copolymer concentration as in [ 41 ]. They can be approximated by linear functions and their intersection corresponded to the CAC copolymers in water.…”

Section: Resultsmentioning

confidence: 99%

“…Our studies have shown that amphiphilic copolymers based on N -vinylpyrrolidone (VP) with branches in polymer chains proved to be promising as platforms for lipophilic compounds (zinc tetraphenylporphyrinate, iron nitrosyl complexes, fullerenes, methyl pheophorbide a, etc.) [ 39 , 40 , 41 , 42 , 43 ] with low cytotoxicity and ability to penetrate cells in vitro to deliver the active agent [ 39 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

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Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone

et al. 2023

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Water-soluble forms of α-tocopherol (TP) as an effective antioxidant were obtained by encapsulating it into nanoparticles (NPs) of amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate (CPL1-TP) and N-vinylpyrrolidone with hexyl methacrylate and triethylene glycol dimethacrylate (CPL2-TP) synthesized by radical copolymerization in toluene. The hydrodynamic radii of NPs loaded with TP (3.7 wt% per copolymers) were typically ca. 50 or 80 nm depending on copolymer composition, media, and temperature. Characterization of NPs was accomplished by transmission electron microscopy (TEM), IR-, and 1H NMR spectroscopy. Quantum chemical modeling showed that TP molecules are capable to form hydrogen bonds with donor groups of the copolymer units. High antioxidant activity of both obtained forms of TP has been found by the thiobarbituric acid reactive species and chemiluminescence assays. CPL1-TP and CPL2-TP effectively inhibited the process of spontaneous lipid peroxidation as well as α-tocopherol itself. The IC50 values of luminol chemiluminescence inhibition were determined. Antiglycation activity against vesperlysine and pentosidine-like AGEs of TP water-soluble forms was shown. The developed NPs of TP are promising as materials with antioxidant and antiglycation activity and can be used in various biomedical applications.

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Section: Resultsmentioning

confidence: 99%