Membranoproliferative Glomerulonephritis in Pregnancy

Nair, Devika; Kidd, Laura; Krane, N. Kevin

doi:10.1016/j.amjms.2017.01.007

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…Steroids are the most widely used immunosuppressive therapy for MPGN during pregnancy because of their safety profile and proven efficacy in pregnant women (13,14). MPGN is less responsive to steroids than other glomerular diseases, such as minimal change nephrotic syndrome and membranous nephropathy.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have shown a higher perinatal risk in pregnancies of patients with MPGN than in those with other glomerular diseases. However, recent studies have revealed that the most important factors are the degree of renal impairment and presence of hypertension (13). Successful deliveries have long been reported in MPGN cases with negative or mild proteinuria and normotension (17,18).…”

Section: Discussionmentioning

confidence: 99%

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Successful Pregnancy and Delivery in a Chronic Renal Failure Patient with Membranoproliferative Glomerulonephritis and Preeclampsia-related Nephrotic Syndrome

Nakai,

Sato,

Nohara

et al. 2024

Intern. Med.

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A 37-year-old woman with chronic kidney disease stage (CKD) G4 with membranoproliferative glomerulonephritis was hospitalized for nephrotic syndrome and hypertension due to superimposed preeclampsia at 27 weeks into her third pregnancy. Proteinuria did not worsen significantly after pulse steroid therapy. Delivery was induced at 30 weeks' gestation due to the maternal renal function and fetal growth. No obvious fetal complications other than preterm delivery were observed. In this case, we successfully managed a high-risk patient with membranoproliferative glomerulonephritis complicated by advanced CKD, nephrotic syndrome, and hypertension, which are independent risk factors for pregnancy complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful Pregnancy and Delivery in a Chronic Renal Failure Patient with Membranoproliferative Glomerulonephritis and Preeclampsia-related Nephrotic Syndrome

Nakai,

Sato,

Nohara

et al. 2024

Intern. Med.

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“…Neonatal mortality of low birth weight infants (< 2500 g) in Japan decreased from 8.8% in 1980 to 0.8% in 2010. More than 90% of infants born at 28 weeks or later survive now [ 3 , 4 ]. Due to the improvement of obstetrical and perinatal care, 99% of 504 pregnancies in women with CKD stages 1–5 resulted in live births during 2000–2013.…”

Section: Discussionmentioning

confidence: 99%

“…In these reports the effects of hypertension, renal dysfunction or heavy proteinuria during pregnancy was not discussed. MPGN associated with hepatitis C virus infection was not excluded from idiopathic MPGN until 1993 [ 3 ]. Progress of obstetrical management and perinatal care improved prognosis of preterm and low birth weight infant [ 4 , 5 ], even in women with chronic kidney disease (CKD) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Progress of obstetrical management and perinatal care improved prognosis of preterm and low birth weight infant [ 4 , 5 ], even in women with chronic kidney disease (CKD) [ 6 ]. In recent years successful pregnancy in women with MPGN type I has been reported [ 3 , 7 , 8 ]. Incidence of multifetal pregnancies due to the improvement of assisted reproduction technologies and ovulation-inducing hormones has been increasing [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Management and outcome of multifetal gestation in a 35-year-old woman with childhood-onset membranoproliferative glomerulonephritis type I

Motoyama

Sakai

Iitaka³

2018

CEN Case Rep

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A 35-year-old woman with membranoproliferative glomerulonephritis type I had quintuplet gestation after induced ovulation. Her serum creatinine level and estimated glomerular filtration rate were 0.86 mg/dL and 61.5 mL/min/1.73 m before pregnancy. Blood pressure was normal and urinary protein to creatinine ratio was 0.2 g/gCr. Prednisolone 10 mg on alternate-day administration was continued during pregnancy. At 10 weeks of gestation transvaginal selective embryo reduction was performed and five embryos were reduced to twins. Hypertension occurred at 20 weeks of gestation. She developed nephrotic syndrome and serum creatinine level increased to 1.29 mg/dL. Elective cesarean section was performed at 28 weeks of gestation and dichorionic diamniotic twins were born. After delivery blood pressure, serum creatinine level, estimated glomerular filtration rate and serum albumin level in their mother returned to baseline. Her twin infants were well at discharge from neonatal-intensive-care-unit. Incidence of multifetal pregnancies due to the improvement of assisted reproduction technologies and ovulation-inducing hormones has been increasing. Management for multifetal pregnancy in women with chronic kidney disease will be needed further.

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