Membranes in Controlled Release

Peppas, Nicholas A.; Wood, Kristy M.; Thomas, J. Brock

doi:10.1002/9783527631360.ch6

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…The molecular weight between crosslinks ($ \overline M _c $ ) was calculated with the Peppas–Merril equation [Eq. (3)] for neutral hydrogels crosslinked in the presence of a solvent19 as described previously 20 …”

Section: Methodsmentioning

confidence: 99%

Characterization of pH‐responsive hydrogels of poly(itaconic acid‐g‐ethylene glycol) prepared by UV‐initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

Betancourt

Pardo

Soo

et al. 2009

J Biomedical Materials Res

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Effective oral delivery of proteins is impeded by steep pH gradients and proteolytic enzymes in the gastrointestinal tract, as well as low absorption of the proteins into the bloodstream due to their size, charge or solubility. In the present work, pH-responsive complexation hydrogels of poly(itaconic acid) with poly(ethylene glycol) grafts were synthesized for applications in oral drug delivery. These hydrogels were expected to be in collapsed configuration at low pH due to hydrogen bonding between poly(itaconic acid) carboxyl groups and poly(ethylene glycol), and to swell with increasing pH because of charge repulsion between deprotonated carboxylic acid groups. Hydrogels were prepared by UV-initiated free radical polymerization using tetraethylene glycol as the crosslinking agent and Irgacure® 2959 as the initiator. The effect of monomer ratios, crosslinking ratio and solvent amount on the properties of the hydrogels were investigated. The composition of the hydrogels was confirmed by FTIR. Equilibrium swelling studies in the pH range of 1.2 to 7 revealed that the extent of swelling increased with increasing pH up to a pH of about 6, when no further carboxylic acid deprotonation occurred. Studies in Caco-2 colorectal carcinoma cells confirmed the cytocompatibility of these materials at concentrations of up to 5 mg/ml.

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Section: Methodsmentioning

confidence: 99%

Characterization of pH‐responsive hydrogels of poly(itaconic acid‐g‐ethylene glycol) prepared by UV‐initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

Betancourt

Pardo

Soo

et al. 2009

J Biomedical Materials Res

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“…This is probably due to the use of an ionic component (i.e., TMAMA) when fabricating the PFHCMs with the water-soluble macromolecules (i.e., PFHCM1-PFHCM4), typically inducing higher hydrogel swelling. 32,33 PFHCM5 and PFHCM6 exhibited the Q e values of 3.65 and 3.71, respectively, and the Q e values of PFHCM7 and PFHCM8 are 3.92 and 3.82, respectively.…”

Section: Equilibrium Swelling Of Pfhcmsmentioning

confidence: 96%

Development of porous fabric‐hydrogel composite membranes with enhanced ion permeability for microalgal cultivation in the ocean

Kim

Choi

Kim

et al. 2019

J of Applied Polymer Sci

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This article presents a strategy to develop the porous fabric-hydrogel composite membranes (PFHCMs) with high nitrate ion (NO 3 − , a source of a main nutrient, nitrogen) permeability and sufficient mechanical strength required for microalgal cultivation in the ocean. The porous structure in the PFHCMs is generated by using three different types of porogens: water-soluble macromolecules, surfactant micelles, and CaCO 3 microparticles. Various PFHCMs, composed mainly of poly(hydroxyethyl methacrylate) hydrogels and cotton fabric, are prepared with varying the content of monomer, initiator, and crosslinker and the type and content of porogen. Their morphological, physical, and mechanical properties are characterized for variables. Among three porogens, the surfactant micelles with a large enough amount produce the optimal PFHCMs with NO 3 − ion permeability coefficient (5.49 × 10 −8 m 2 min −1 , approximately 5 and 20 times higher than those of the fabric-hydrogel composite membranes, synthesized without any porogen in a previous work, and the commercial cellulose acetate membranes, respectively). Their mechanical strength (i.e., the ultimate stress is 9.37 MPa) is high enough for practical uses. Therefore, these PFHCMs are good candidate membranes in microalgal cultivation for biorefinery and other biomedical applications, including wound dressings.

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“…Th e broad potential of these materials is also refl ected in the signifi cant number of published reviews focused on the latest developments and applications of multifunctional responsive polymeric membranes [1][2][3][4][5][6][7]. Membranes are essential for life.…”

Section: Introductionmentioning

confidence: 99%

“…During the last three decades, functional groups that respond to changes in pH, temperature, ionic strength, specifi c chemical species, light, electric fi elds, magnetic fi elds, and mechanical stresses have all been applied to regulate membrane properties; pH, temperature, and light-responsive membranes have been the most studied [1][2][3][4][5][6][7]8]. During the last three decades, functional groups that respond to changes in pH, temperature, ionic strength, specifi c chemical species, light, electric fi elds, magnetic fi elds, and mechanical stresses have all been applied to regulate membrane properties; pH, temperature, and light-responsive membranes have been the most studied [1][2][3][4][5][6][7]8].…”

Section: Introductionmentioning

confidence: 99%

Photo‐Responsive Hydrogels for Adaptive Membranes

Díaz

Johnson

2014

Smart Membranes and Sensors

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Synthetic membranes that show a selective and reversible response to a specifi c environmental cue (e.g., a change in pH, temperature, ionic strength, electromagnetic fi eld, irradiation) are platform materials for high-tech applications that demand switchable material properties. Mechanistically, stimuli-responsive membranes leverage reversible molecular properties of the membrane components, like conformation, polarity, and/or reactivity, to induce changes in the bulk pore structure. Among the many possible external stimuli, light is particularly attractive as it can be applied both spatially and temporally without diff usion limitations. Th is chapter describes the permeability properties of a selection of representative photo-responsive hydrogel membranes. Th e membranes are classifi ed according to their chromophore structures.

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Membranes in Controlled Release

Cited by 3 publications

References 29 publications

Characterization of pH‐responsive hydrogels of poly(itaconic acid‐g‐ethylene glycol) prepared by UV‐initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

Characterization of pH‐responsive hydrogels of poly(itaconic acid‐g‐ethylene glycol) prepared by UV‐initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

Development of porous fabric‐hydrogel composite membranes with enhanced ion permeability for microalgal cultivation in the ocean

Photo‐Responsive Hydrogels for Adaptive Membranes

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