Membraneless reproducible MoS2 field-effect transistor biosensor for high sensitive and selective detection of FGF21

Gong, Xiao; Liu, Yeru; Xiang, Haiyan; Liu, Huan; Liu, Zhigang; Zhao, Xiaorui; Li, Jishan; Li, Huimin; Guo, Hong; Travis, Shihao Hu; Chen, Hong; Liu, Song; Yu, Gang

doi:10.1007/s40843-019-9444-y

Cited by 19 publications

(13 citation statements)

References 41 publications

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“…After introducing the sample containing the target analyte, and accordingly the production of Ab-Ag complexes, the detection occurred and a LoD of 10 fg·mL −1 was recorded. This device demonstrated a satisfactory selectivity even in complex serum samples [ 145 ]. A DNA biosensor based on a MoS 2 -based FET was introduced which employed phosphorodiamidate morpholino oligos (PMO)-DNA hybridization as their detection strategy.…”

Section: Surface Modification and Functionalization Of Chem/biofetsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19.

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Section: Surface Modification and Functionalization Of Chem/biofetsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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“…In MAFLD, NGs’ synthesis was very limited to developing sensors as essential indicators for clinical diagnosis, and prognosis judgment, including environment-friendly immunosensor of leptin using porous graphene-functionalized black phosphorus and gold nanoparticles successfully [ 140 ]. The sensitive and selective biosensor was also reported for the fibroblast growth factor 21 as an important MAFLD biomarker [ 141 ], while there was no record on anti-MAFLD NGs as drug delivery systems or the synergetic impact of NGs alone on one or more MAFLD manifestation.…”

Section: Opportunities and Limitations Of Nanosystems For Mafld Thmentioning

confidence: 99%

The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

2021

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Current research indicates that the next silent epidemic will be linked to chronic liver diseases, specifically non-alcoholic fatty liver disease (NAFLD), which was renamed as metabolic-associated fatty liver disease (MAFLD) in 2020. Globally, MAFLD mortality is on the rise. The etiology of MAFLD is multifactorial and still incompletely understood, but includes the accumulation of intrahepatic lipids, alterations in energy metabolism, insulin resistance, and inflammatory processes. The available MAFLD treatment, therefore, relies on improving the patient’s lifestyle and multidisciplinary pharmacotherapeutic options, whereas the option of surgery is useless without managing the comorbidities of the MAFLD. Nanotechnology is an emerging approach addressing MAFLD, where nanoformulations are suggested to improve the safety and physicochemical properties of conventional drugs/herbal medicines, physical, chemical, and physiological stability, and liver-targeting properties. A wide variety of liver nanosystems were constructed and delivered to the liver, only those that addressed the MAFLD were discussed in this review in terms of the nanocarrier classes, particle size, shape, zeta potential and offered dissolution rate(s), the suitable preparation method(s), excipients (with synergistic effects), and the suitable drug/compound for loading. The advantages and challenges of each nanocarrier and the focus on potential promising perspectives in the production of MAFLD nanomedicine were also highlighted.

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“…Sensing strategies and devices for microorganism have been reported based on different principles and TMDC-based FET has recently become newly emerged sensing platform for microorganisms. The reports of TMDC FET sensors for the detection of various biomolecules including proteins [31,32,81,[134][135][136][137][138][139][140][141][142][143] and nucleic acids (DNA/RNA) [26][27][28][29][144][145][146][147][148][149] TiO 2 FETs [150], in which vancomycin with bio-affinity to S. aureus was functionalized onto MoS 2 via a TiO 2 layer, contributing to the efficient discriminating ability of the sensor between Gram-positive and Gram-negative bacteria. The detection of Ebola, a lethal virus, was achieved with FET sensors with liquid-phase exfoliated MoS 2 [151], in which selective detection relied on the bio-recognition of a specific protein VP40 antigen on Ebola.…”

Section: Detection Of Microorganismsmentioning

confidence: 99%

Environmental Analysis with 2D Transition-Metal Dichalcogenide-Based Field-Effect Transistors

2020

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• Recent advances of two-dimensional (2D) transition-metal dichalcogenide (TMDC)-based field-effect transistor (FET) sensors for environmental analysis are summarized. • Representative TMDC FET sensors in gaseous and aqueous media analysis are introduced. • Challenges and future research directions of 2D TMDC FET sensors are discussed. ABSTRACT Field-effect transistors (FETs) present highly sensitive, rapid, and in situ detection capability in chemical and biological analysis. Recently, two-dimensional (2D) transition-metal dichalcogenides (TMDCs) attract significant attention as FET channel due to their unique structures and outstanding properties. With the booming of studies on TMDC FETs, we aim to give a timely review on TMDCbased FET sensors for environmental analysis in different media. First, theoretical basics on TMDC and FET sensor are introduced. Then, recent advances of TMDC FET sensor for pollutant detection in gaseous and aqueous media are, respectively, discussed. At last, future perspectives and challenges in practical application and commercialization are given for TMDC FET sensors. This article provides an overview on TMDC sensors for a wide variety of analytes with an emphasize on the increasing demand of advanced sensing technologies in environmental analysis.

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Membraneless reproducible MoS2 field-effect transistor biosensor for high sensitive and selective detection of FGF21

Cited by 19 publications

References 41 publications

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

Environmental Analysis with 2D Transition-Metal Dichalcogenide-Based Field-Effect Transistors

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