Membrane vs Bubble Oxygenator

Abstract

Numerous studies have demonstrated the superiority of membrane oxygenators (MO) over the bubble oxygenators (BO) when used for prolonged cardiopulmonary support. However, there is little information available evaluating the MO for routine, short-term cardiopulmonary bypass. In this study the 5MO314 Modulung-Teflo (MO) was compared to 5M30314 Miniprime Variflo (BO). The data of 91 patients (46 MO and 45 BO) were analyzed according to the duration of cardiopulmonary bypass (Group I less than 60 min., Group II 60-90 min. and Group III greater than 90 min.). Hemodynamic parameters, fluid and blood balance, as well as hematologic and blood gas studies were used for comparing the two oxygentors. The hemodynamic parameters were better, and the arterial blood gases were more physilogic with the MO. The postoperative blood loss was significantly less when using the MO. The other measurements documented the stability of the MO. All statements were based on statistical analysis with a DEC PDP-9 computer, using the MIIS language and operating system. Consequently, we are now using this MO for routine cardiopulmonary bypass.

Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation

“…As had been witnessed earlier by Gibbon and colleagues, researchers seeking to develop new oxygenators found that direct exposure of blood to atmosphere, whether in a rotating cylinder, rotating disc , screen cascade , or bubbling system , would cause foaming of the blood. The foaming action led to blood trauma and loss of blood products during and following oxygenator usage . While brief atmospheric exposure could be accommodated during cardiopulmonary bypass, the rapid consumption of blood products and risk of arterial gas emboli during life support sessions greater than several hours generated demand for new oxygenator designs.…”

Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle

“…With our concept, two main aspects result: First, the impact of the blood-air contact on the hemocompatibility. Bubble oxygenators have been associated with blood trauma [25] and are no longer clinically used. However, in our approach is has to be taken into account that, compared to approx.…”

“…In order to examine the feasibility and limitations of the EHT regarding the detoxification velocity, we performed two series of experiments. Preliminary experiments comparing the performance of hollow fibre membrane oxygenators (HFMO) versus a specifically designed batch oxygenator (BO) based on the bubble oxygenator principle [25] were conducted. Subsequently, the more promising option was revised, and the performance regarding the detoxification velocity was tested for a broader range of operating points.…”

Bioengineering Progress in Lung Assist Devices

“…Although a remarkable medical advancement, direct-contact oxygenators left much to be desired. The blood-gas interface was identified as a source of blood trauma, pro-tein denaturation, coagulation disorders, and microembolisms [32][33][34][35], and the associated vascular problems ranged from deficient peripheral perfusion to progressive organ failure [36]. Such complications could typically be managed over the duration of intracardiac surgery [37], but for patients requiring longer-term lung pulmonary circumvention, directcontact oxygenators were of little assistance.…”