Membrane Translocation and Organelle-Selective Delivery Steered by Polymeric Zwitterionic Nanospheres

Morimoto, Nobuo; Wakamura, Masaru; Muramatsu, Kanna; Toita, Sayaka; Nakayama, Masafumi; Watanabe, Shôji; Suzuki, Makoto; Winnik, Françoise M.

doi:10.1021/acs.biomac.6b00172

Cited by 32 publications

(49 citation statements)

References 55 publications

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“…Figure 1b summarizes the possible intermolecular interactions of P(PySMAAm) in pure water. A simple sulfobetaine polymer having an aliphatic structure, such as PDMAPS, is considered to be aggregated by the attractive forces of the dipole–dipole interaction and hydrophobic interaction 21. The dipole–dipole interaction can occur between inter or intrapolymer side chains.…”

Section: Resultsmentioning

confidence: 99%

The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions

Morimoto

Oishi

Yamamoto

2020

Macro Chemistry & Physics

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Thermoresponsive polymers are attractive in terms of basics and applications because of the phase separation in aqueous solution. Some sulfobetaine polymers are known for their antifouling biocompatibility and upper critical solution temperature (UCST) type thermoresponsiveness; however, thermoresponsiveness disappears in aliphatic sulfobetaine polymers in physiological salt conditions. Aromatic cation‐containing sulfobetaine polymers are not responded because of the strong intermolecular interactions. In this study, new sulfobetaine methacrylamides with a pyridinium cation, 3‐(4‐(2‐methacrylamido)alkyl pyridinio‐1‐yl)propane‐1‐sulfonates, (PySMAAm)s, are designed and then prepared the homopolymers using aqueous reversible addition‐fragmentation chain transfer polymerization. The P(PySMAAm)s exhibited UCST‐type thermoresponsiveness that is induced by substitution of the dipole–dipole interaction between the interpolymer side chain to an ion–dipole interaction in physiological salt conditions. The thermoresponsiveness is affected by the molecular weight and structure of the side chains. Such sulfobetaine polymers can be promising tools as biomaterials especially for drug delivery and regenerative medicine.

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Section: Resultsmentioning

confidence: 99%

The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions

Morimoto

Oishi

Yamamoto

2020

Macro Chemistry & Physics

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“…Researchers have synthesized a zwitterionic polymer P (AM-DMC-AMPS) as a low-molecular-weight encapsulator in deepwater drilling fluid, and it showed strong shale inhibition performance [12]. So far, however, there are few reports on low molecular weight zwitterionic copolymers as shale inhibitors [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The Inhibition Property and Mechanism of a Novel Low Molecular Weight Zwitterionic Copolymer for Improving Wellbore Stability

Slaný

Wang

et al. 2020

Polymers

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In this work, a novel low molecular weight zwitterionic copolymer for improving wellbore stability, which is expected to be an alternative to the current shale inhibitors, was obtained by copolymerization of tris hydroxyethyl allyl ammonium bromide (THAAB), 2-acrylamido-2- methyl propane sulfonic acid (AMPS) and acrylamide (AM), initiated by a redox initiation system in an aqueous solution. The copolymer, denoted as SX-1, was characterized by FT-IR, TGA-DSC, and GPC. Results demonstrated that the molecular weight of SX-1 was approximately 13,683 g/mol and it displayed temperature resistance up to 225 °C. Regarding the inhibition performance, evaluation experiments showed the hot rolling recovery of a Longmaxi shale sample in 2.0 wt % SX-1 solutions was up to 90.31% after hot rolling for 16 h at 120 °C. The Linear swelling height of Na-MMT artificial core in 2.0 wt % SX-1 solution was just 4.74 mm after 16 h. Methods including particle size analysis, FTIR, XRD, and SEM were utilized to study the inhibition mechanism of SX-1; results demonstrated that SX-1 had entered into the inner layer of sodium montmorillonite (Na-MMT) and adsorbed on the inner surface, and the micro-structure of Na-MMT was successfully changed by SX-1. The particle size of Na-MMT in distilled water was 8.05 μm, and it was observed that its size had increased to 603 μm after the addition of 2.0 wt % of SX-1. Its superior properties make this novel low molecular weight copolymer promising for ensuring wellbore stability, particularly for high temperature wells.

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“…Among them, polymer aggregates are most promising because they can cross cell membranes by simple diffusion. [106][107][108][109] In Section 5.2, the mechanism of cell membrane permeation of amphiphilic polymer aggregates by simple diffusion will be described.…”

Section: Mechanism Of Cell Membrane Permeation By Macromoleculesmentioning

confidence: 99%

Redox‐Active Polymers Connecting Living Microbial Cells to an Extracellular Electrical Circuit

Kaneko

Ishihara

Nakanishi

2020

Small

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Microbial electrochemical systems in which metabolic electrons in living microbes have been extracted to or injected from an extracellular electrical circuit have attracted considerable attention as environmentally‐friendly energy conversion systems. Since general microbes cannot exchange electrons with extracellular solids, electron mediators are needed to connect living cells to an extracellular electrode. Although hydrophobic small molecules that can penetrate cell membranes are commonly used as electron mediators, they cannot be dissolved at high concentrations in aqueous media. The use of hydrophobic mediators in combination with small hydrophilic redox molecules can substantially increase the efficiency of the extracellular electron transfer process, but this method has side effects, in some cases, such as cytotoxicity and environmental pollution. In this Review, recently‐developed redox‐active polymers are highlighted as a new type of electron mediator that has less cytotoxicity than many conventional electron mediators. Owing to the design flexibility of polymer structures, important parameters that affect electron transport properties, such as redox potential, the balance of hydrophobicity and hydrophilicity, and electron conductivity, can be systematically regulated.

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Membrane Translocation and Organelle-Selective Delivery Steered by Polymeric Zwitterionic Nanospheres

Cited by 32 publications

References 55 publications

The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions

The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions

The Inhibition Property and Mechanism of a Novel Low Molecular Weight Zwitterionic Copolymer for Improving Wellbore Stability

Redox‐Active Polymers Connecting Living Microbial Cells to an Extracellular Electrical Circuit

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