Membrane Transduction of Low Energy Level Fields and the Ca++ Hypothesis

Findl, E.

doi:10.1007/978-1-4899-1968-7_2

Cited by 14 publications

References 85 publications

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Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells

Kruglikov

Dertinger

1994

Bioelectromagnetics

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The most important but still unresolved problem in bioelectromagnetics is the interaction of weak electromagnetic fields (EMFs) with living cells. Thermal and other types of noise pose restrictions in cell detection of weak signals. As a consequence, some extant experimental results that indicate low-intensity field effects cannot be accounted for, and this renders the results themselves questionable. One way out of this dead end is to search for possible mechanisms of signal amplification. In this paper, we discuss a general mechanism in which a weak signal is amplified by system noise itself. This mechanism was discovered several years ago in physics and is known, in its simplest form, as a stochastic resonance. It was shown that signal amplification may exceed a factor of 1000, which renders existing estimations of EMF thresholds highly speculative. The applicability of the stochastic resonance concept to cells is discussed particularly with respect to the possible role of the cell membrane in the amplification process.

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Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells

Kruglikov

Dertinger

1994

Bioelectromagnetics

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Electrical Control Of Plant Morphogenesis

Carmen¹

Plan Tissue Culture Engineering

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Modified cell proliferation due to electrical currents

Vodovnik

Miklavčič

Serša

1992

Med. Biol. Eng. Comput.

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In view of the evidence that electrical currents may enhance healing of chronic wounds and retard tumour growth it is suggested that these currents normalise cell proliferation. Additional support to this contention is given by two reports: one on healing of pressure sores in man and one on tumour growth retardation in mice. The effect of an ionic environment on the cell cycle is analysed. Finally a hypothesis attempting to explain the normalising effect of electrical currents on cell proliferation is proposed. It is known that non-dividing cells, e.g. mature neurons, have high transmembrane potential (TMP) whereas fast-dividing cells, e.g. cancerous cells, have low TMP. When a cell is exposed to an electrical field, one side of the cell becomes hyperpolarised while the opposite side is depolarised. Assuming a nonlinear relationship between TMP and the transmembrane ionic currents, it can be shown that in non-dividing cells their high TMP is lowered; whereas in cells with a high division rate, their low TMP is raised due to cell exposure to the external electrical field. These alterations in transmembrane potential could contribute to the normalisation of abnormal cell proliferation.

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Membrane Transduction of Low Energy Level Fields and the Ca++ Hypothesis

Cited by 14 publications

References 85 publications

Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells

Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells

Electrical Control Of Plant Morphogenesis

Modified cell proliferation due to electrical currents

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