Membrane supported poly(butylene adipate-co-terephthalate) nanofibrous matrices as cardiac patch: Effect of basement membrane for the fiber deposition and cellular behavior

Gültan, Tuğçe; Gümüşderelı́oğlu, Menemşe

doi:10.1016/j.colsurfa.2022.129977

Cited by 2 publications

(1 citation statement)

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“…[18,19] The PBAT-based scaffolds have been used in bone tissue engineering; [19,20] more recently, they have been used to form nanofibrous matrices for cardiac plasters [21] and wound healing patches. [22,23] Incorporating PBAT into PLA contributes to overcoming the limitations presented by PLA and allows the production of materials with improved mechanical and transport properties. [24,25] Polymer blends are recognized to reduce the undesired side effects of many drugs, particularly, those biological agents in which drug release is very important.…”

Section: Introductionmentioning

confidence: 99%

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Liparoti,

Mottola,

De Marco

et al. 2023

Macro Materials & Eng

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Topical administration is the preferred route for the controlled release of active compounds since it reduces side effects typical of other administration methods. The use of polymer blends is a way to modulate drug release from a topical device. The blends ensure modulation of a wide range of properties, such as mechanical properties, water sorption, and degradation. This paper proposes blends of poly(lactide acid) (PLA), and Poly(butylene adipate‐co‐terephthalate) (PBAT), for the topical release of caffeine, a molecule with anti‐inflammatory, antioxidant, and anticellulite activities. PBAT/PLA blends are optimized for compatibility between the two polymers, mechanical properties, and drug release rate. Blends with a higher amount of PBAT show the best performance regarding polymer compatibility. The blends undergo supercritical CO2‐assisted caffeine impregnation. This process assures homogeneous dispersion of caffeine into the polymer matrix. The ratios 45/55 and 55/45 PBAT/PLA show the best performance in terms of caffeine release (complete caffeine release within 25 h). Caffeine is released into three steps: a burst effect due to the caffeine dispersed over the film surface, a slower release due to the caffeine dispersed in the polymer matrix, and a fast release due to the increase of polymer degradation rate induced by caffeine presence.

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