1976
DOI: 10.1016/0009-8981(76)90514-3
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Membrane permeability in normal human lymphocytes and lymphocytes from patients with chronic lymphatic leukaemia

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1976
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Cited by 9 publications
(5 citation statements)
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“…Enhancing or blocking antibodies have been described in relation to tumour growth or regression (Sjogren et a / , 1972;Baldwin et al, 1972) but there is no special reason why an antibody should be responsible for the effects seen here. Many small molecules which could affect the energy level of the cell or culture medium might be responsible for this 'serum' factor effect (Hallak & Wilkinson, 1976). However, since our first examination of CLL sera was carried out in the belief that 'enhancing' or 'blocking' antibodies may be present, this was the first avenue to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…Enhancing or blocking antibodies have been described in relation to tumour growth or regression (Sjogren et a / , 1972;Baldwin et al, 1972) but there is no special reason why an antibody should be responsible for the effects seen here. Many small molecules which could affect the energy level of the cell or culture medium might be responsible for this 'serum' factor effect (Hallak & Wilkinson, 1976). However, since our first examination of CLL sera was carried out in the belief that 'enhancing' or 'blocking' antibodies may be present, this was the first avenue to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…Several apparently unrelated observations dealing with, for example, the location of serum proteins in the nucleus (55) and the leakage of cytoplasmic proteins from intact cells (23,32,54)may be accounted for by assuming that the nuclear and plasma membranes and probably other intracellular membranes as well are permeable to certain macromolecules by diffusion as implied in this membrane model. This permeability, is an intersting weakness of tumor cells because of the possibility of introducing macromolecular agents that are harmful for their proliferative metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…A model for the diffusion of water soluble proteins across adenylate kinase (5), NDP kinase (2), ATPase (3, 43), and protein kinase (6, 44). Phenomena such as ghost resealing ( c $ :26), secretion of proteins apparently without exocytosis (23,32), and the transport of polynucleotides across intact plasma membranes (cf. : 36)are difficult to explain with the traditional lipid bilayer concept of a plasma membrane.…”
mentioning
confidence: 99%
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“…Differences were also found in the cryobiological characteristics of the immune cells. Hallak et al demonstrated that cell membrane permeabilities to water depended on the donors' health condition and age [86]. This difference in cell membrane property may explain the different performance of those immune cells in surviving cryopreservation.…”
Section: Impacts Of Cryopreservation On Immune Cell Functionsmentioning
confidence: 99%