Membrane patterning through horizontally aligned microchannels developed by sulfated chopped carbon fiber for facile permeability of blood plasma components in low-density lipoprotein apheresis

Dehghan, Rahim; Barzin, Jalal

doi:10.1016/j.seppur.2021.119512

Cited by 6 publications

(3 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Einstein-Stocks relation 45 (equation (7)) relates the average molecular weight of each PVP to its particle size. The calculated particle diameters are:• PVP 10 kDa 3.96 nm• PVP 50 kDa 10.28 nm• PVP 360 kDa 33.13 nm• PVP 1200 kDa 67.65 nm.Where…”

Section: Resultsmentioning

confidence: 99%

Evaluation of solubility parameters and relative energy difference (RED) on the preparation of polysulfone/polyethylene glycol membrane: A study on the casting solution and coagulation bath

Dehghan,

Kordkatooli,

Barzin

2023

Journal of Plastic Film & Sheeting

Self Cite

View full text Add to dashboard Cite

Solubility parameters are effective factors for controlling membrane preparation based on hydrophilic/hydrophobic polymers. Hansen solubility parameters (HSPs) of a polysulfone/polyethylene glycol (PSU/PEG) in increasing PEG molecular weights and binary coagulation bath of solvent/non-solvent mixtures are investigated. The results revealed that with increased PEG molecular weight in the casting solution, the relative energy difference (RED) of the solution increases, and subsequently its instability increases too. On the other hand, by increasing the solvent in the coagulation bath, RED decreases. Findings demonstrated that by increasing PEG molecular weight to 15,000 g/mol and increasing solvent to 60 wt% in the coagulation bath, an interconnected sponge-like structure with maximum mean pore size (120 nm) was achieved. With increased PEG molecular weight, membrane morphology tended toward to a sponge-like structure due to delayed demixing in the phase inversion stage. Furthermore, pure water permeability and rejection capability of membranes exhibited that with increasing RED of casting solution and reducing RED of coagulation bath, the highest permeability (2199 L/m2h and the lowest rejection capability (33%) of the membrane were attained. This study confirmed that, for the PSU/PEG system, by controlling the solubility parameters, RED value of casting solution and coagulation bath, membrane characteristics can be controlled.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of solubility parameters and relative energy difference (RED) on the preparation of polysulfone/polyethylene glycol membrane: A study on the casting solution and coagulation bath

Dehghan,

Kordkatooli,

Barzin

2023

Journal of Plastic Film & Sheeting

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main strategies for reducing LDL concentration levels include dietary adjustments, lipid-lowering medications (mostly statins), and low-density lipoprotein apheresis (LDL-a) . The first two methods exhibit limited therapeutic efficacy for patients with familial hyperlipidemia and may develop resistance to lipid-lowering drugs with prolonged use. − LDL-a, a blood purification technique, efficiently and selectively removes excess LDL through the LDL adsorbents. , The LDL adsorbents include immunoadsorbents, hydrophobic adsorbents, , and ion exchange adsorbents. − Present reported adsorbents utilize hydrophobic sites for binding cholesterol on LDL and negatively charged sites for binding positively charged Apo B-100 of LDL …”

Section: Introductionmentioning

confidence: 99%

“…10−12 LDL-a, a blood purification technique, efficiently and selectively removes excess LDL through the LDL adsorbents. 13,14 The LDL adsorbents include immunoadsorbents, 15 hydrophobic adsorbents, 16,17 and ion exchange adsorbents. 18−21 hydrophobic sites for binding cholesterol on LDL and negatively charged sites for binding positively charged Apo B-100 of LDL.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy

Xiao,

Xu,

Liu

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

Atherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglitazone (R), the fabricated AA-CSA-CD-R microspheres could simultaneously release R and facilitate LDL removal for hemoperfusion. The AA and CSA offer electrostatic adsorption sites for LDL, while the CD provides hydrophobic adsorption sites for LDL and weak binding sites for R. According to the Sips model, the maximum static LDL adsorption capacity of AA-CSA-CD-R is determined to be 614.73 mg/g. In dynamic simulated perfusion experiments, AA-CSA-CD-R exhibits an initial cycle LDL adsorption capacity of 150.97 mg/g. The study suggests that the weakened inflammatory response favors plaque stabilization. The anti-inflammatory property of the microspheres is verified through an inflammation model, wherein the microsphere extracts are cocultured with mouse macrophages. Both qualitative analysis of iNOS\TNF-α and quantitative analysis of IL-6\TNF-α collectively demonstrate the remarkable anti-inflammatory effect of the microspheres. Therefore, the current study presents a novel blood purification treatment of eliminating pathogenic factors and introducing therapeutic factors to stabilize AS plaque.

show abstract

Microbead-based extracorporeal immuno-affinity virus capture: a feasibility study to address the SARS-CoV-2 pandemic

et al. 2023

View full text Add to dashboard Cite

In this paper, we report on the utilization of micro-technology based tools to fight viral infections. Inspired by various hemoperfusion and immune-affinity capture systems, a blood virus depletion device has been developed that offers highly efficient capture and removal of the targeted virus from the circulation, thus decreasing virus load. Single-domain antibodies against the Wuhan (VHH-72) virus strain produced by recombinant DNA technology were immobilized on the surface of glass micro-beads, which were then utilized as stationary phase. For feasibility testing, the virus suspension was flown through the prototype immune-affinity device that captured the viruses and the filtered media left the column. The feasibility test of the proposed technology was performed in a Biosafety Level 4 classified laboratory using the Wuhan SARS-CoV-2 strain. The laboratory scale device actually captured 120,000 virus particles from the culture media circulation proving the feasibility of the suggested technology. This performance has an estimated capture ability of 15 million virus particles by using the therapeutic size column design, representing three times over-engineering with the assumption of 5 million genomic virus copies in an average viremic patient. Our results suggested that this new therapeutic virus capture device could significantly lower virus load thus preventing the development of more severe COVID-19 cases and consequently reducing mortality rate. Graphical Abstract

show abstract

Membrane patterning through horizontally aligned microchannels developed by sulfated chopped carbon fiber for facile permeability of blood plasma components in low-density lipoprotein apheresis

Cited by 6 publications

References 79 publications

Evaluation of solubility parameters and relative energy difference (RED) on the preparation of polysulfone/polyethylene glycol membrane: A study on the casting solution and coagulation bath

Evaluation of solubility parameters and relative energy difference (RED) on the preparation of polysulfone/polyethylene glycol membrane: A study on the casting solution and coagulation bath

Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy

Microbead-based extracorporeal immuno-affinity virus capture: a feasibility study to address the SARS-CoV-2 pandemic

Contact Info

Product

Resources

About