Membrane-modifying effect of taurine

Akhalaya, M. Ya.; Кушнарева, Е. А.; Parshina, E. Yu.; Platonov, A. G.; Graevskaya, E.E.

doi:10.1134/s000635091204001x

Cited by 2 publications

(3 citation statements)

References 27 publications

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Section: Discussionmentioning

confidence: 99%

“…It is well known that TAU is a membrane stabilizer [130]. The membrane stabilizing action of TAU on erythrocytes could render their membrane more resistant to reactive species such as ROS and lipid peroxidation byproducts [131][132][133]. Gossai et al also found that TAU significantly stabilized the erythrocyte membrane and enhanced cellular antioxidant capacity [134].…”

Section: •-mentioning

confidence: 99%

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Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Niknahad¹,

Mehrabani²,

Arjmand³

et al. 2023

ceh

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Aim of the study: Cholestasis/cirrhosis could induce erythrocyte lysis. The incidence of various types of anemia in cirrhosis is approx. 75%. Several studies have mentioned the pivotal role of oxidative stress in this complication. Taurine (TAU) is the human body's most abundant free amino acid. TAU is known as a robust cell membrane stabilizer. Many studies have mentioned that TAU could counteract oxidative stress in various experimental models. The current study was intended to evaluate the effect of TAU on erythrocytes in cirrhotic rats. Material and methods: Bile duct ligation (BDL) surgery was carried out on rats. Then, complete blood count (CBC), hemoglobin (Hgb), hematocrit (HTC), and erythrocytes' G6PD, catalase (CAT), and superoxide dismutase (SOD) activity were measured. Moreover, biomarkers of oxidative stress were assessed, and the erythrocytes' morphological changes were monitored in the cirrhotic mice exposed to TAU (0.25%, 0.5%, and 1% w : v in drinking water). Results: Significant changes in the assessed erythrocyte parameters (G6PD activity, Hgb, HTC, and erythrocyte count) and red blood cells (RBC) morphological alterations were detected on day 42 after BDL surgery. Biomarkers of oxidative stress also did not change at the time points, except on post-BDL days 28 and 42. A significant decrease in blood parameters was evident at post-BDL day 42. All doses of TAU (0.25%, 0.5%, and 1% w : v in drinking water) significantly improved erythrocyte parameters and encountered oxidative stress in the erythrocytes of cirrhotic animals. Conclusions: These data indicate that TAU could be a safe agent to mitigate cirrhosis-induced erythrocyte damage and anemia. Further investigations are necessary to prove this in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Section: •-mentioning

confidence: 99%

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Niknahad¹,

Mehrabani²,

Arjmand³

et al. 2023

ceh

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“…Taurine inhibits the activity of phospholipid methyltransferase, which catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine and thus taurine could alter the composition and consequently the properties and stability of phospholipid membranes [40][41][42]. In evidence, the presence of taurine decreased the viscosity of erythrocytic membranes, suggesting taurine might increase membrane fluidity [43].…”

Section: Taurine and Its Role In Protein And Membrane Stabilizationmentioning

confidence: 99%

The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy

Merckx

Paepe

2022

Metabolites

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Taurine (2-aminoethanesulfonic acid) is required for ensuring proper muscle functioning. Knockout of the taurine transporter in mice results in low taurine concentrations in the muscle and associates with myofiber necrosis and diminished exercise capacity. Interestingly, regulation of taurine and its transporter is altered in the mdx mouse, a model for Duchenne Muscular Dystrophy (DMD). DMD is a genetic disorder characterized by progressive muscle degeneration and weakness due to the absence of dystrophin from the muscle membrane, causing destabilization and contraction-induced muscle cell damage. This review explores the physiological role of taurine in skeletal muscle and the consequences of a disturbed balance in DMD. Its potential as a supportive treatment for DMD is also discussed. In addition to genetic correction, that is currently under development as a curative treatment, taurine supplementation has the potential to reduce muscle inflammation and improve muscle strength in patients.

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Membrane-modifying effect of taurine

Cited by 2 publications

References 27 publications

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy

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