Membrane interaction and selectivity of novel alternating cationic lipid-nanodisc assembling polymers

Farrelly, Michelle D.; Zhai, Jiali; Tiong, A. H. K.; Hag, Leonie van ‘t; Yu, Haibin; Li, Jian; Martin, L.; Thang, San H.

doi:10.1039/d3bm00477e

Cited by 1 publication

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References 62 publications

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“…Considering that postmodification is often a practical method when the monomer double bond is conjugated with the desired cationic structure, − an alternative approach (Scheme ) was devised to achieve flavylium-containing polymers through the postmodification of NAPhMA polymers derived from the precursor monomer N -(4-acetylphenyl)methacrylamide (NAPhMA). 1 H NMR analysis of the crude reaction mixture following polymerization confirmed the consumption of monomers and the generation of polymeric products.…”

Section: Resultsmentioning

confidence: 99%

Flavylium-Containing Stimuli-Responsive RAFT Polymers: Synthesis and Enhanced Stability

Liu,

McDonald,

Thang

et al. 2024

Macromolecules

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Flavyliums are abundant naturally occurring, stimuli-responsive cationic chromophores found in anthocyanins that constitute the majority of red and blue pigments found in flora. While synthetic molecular derivatives have been devised to finetune these characteristics, the development of polymeric materials in this regard remains scarce. To address this, a flavylium-based methacrylamide derivative (FlavM-A1) was successfully synthesized, but its radical polymerization proved to be ineffective. To overcome this constraint, a convergent synthetic route for a series of flavylium-containing polymers was developed, employing reversible addition−fragmentation chain transfer (RAFT) polymerization followed by postmodification to install the flavylium chromophore. The flavylium-containing polymers described in this work exhibit improved hydrolytic stability in their flavylium moieties compared to the small-molecule FlavM-A1 while both possess interesting stimuli responsiveness and surfactant-like properties.

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Section: Resultsmentioning

confidence: 99%

Flavylium-Containing Stimuli-Responsive RAFT Polymers: Synthesis and Enhanced Stability

Liu,

McDonald,

Thang

et al. 2024

Macromolecules

Self Cite

View full text Add to dashboard Cite

show abstract

Membrane interaction and selectivity of novel alternating cationic lipid-nanodisc assembling polymers

Abstract: Synthetic polymer nanodiscs are self-assembled structures formed from amphipathic copolymers encapsulating membrane proteins and surrounding phospholipids into water soluble discs. These nanostructures have served as an analytical tool for the...

Cited by 1 publication

References 62 publications

Flavylium-Containing Stimuli-Responsive RAFT Polymers: Synthesis and Enhanced Stability

Flavylium-Containing Stimuli-Responsive RAFT Polymers: Synthesis and Enhanced Stability

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