Membrane Immunological Reactions and Transport

Lauf, Peter K.

doi:10.1007/978-3-642-46370-9_9

Cited by 4 publications

(1 citation statement)

References 181 publications

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“…For example, the membrane potential change associated with the binding of concanavalin A (ConA) or immune complexes to neutrophil leukocytes is thought to be the primary trigger for the phagocytic activity of these cells (Korchak and Weissman, 1978). A rapid membrane potential change has also been observed upon interaction of mitogenic lectins with T lymphocytes (Lauf, 1978;Shapiro et al, 1979;Shapiro and Strom, 19801, chemotactic factors with polymorphonuclear leukocytes, differentiation of ova following interaction with sperm (Epel, 1978), and thrombin with platelets (Seligman et al, 1980). Since EBV is known to be a human B cell mitogen, (Tskuda et al, 1981) we think it likely that the changes in membrane potential observed upon EBV infection of RAMOS may play a role in initiating subsequent mitogenesis or viral infection.…”

Section: Discussionmentioning

confidence: 99%

Cell membrane potential changes follow epstein‐barr virus binding

Rosenthal

Shapiro

1983

Journal Cellular Physiology

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Upon binding to receptor-bearing target cells, viruses cause cell membrane potential changes. Epstein-Barr Virus causes a biphasic membrane potential change in receptor-bearing B lymphocytes but not receptor-negative T lymphocytes, as measured by flow cytometry or cyanine dye uptake. Membrane potential changes from EBV binding to receptor-bearing cells resemble electrical responses of other cells following ligand binding to transmembrane receptors.

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