Membrane heterogeneity – from lipid domains to curvature effects

Semrau, Stefan; Schmidt, Thomas

doi:10.1039/b901587f

Cited by 102 publications

(93 citation statements)

References 207 publications

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“…17,18,[44][45][46][47][48] For example, at phase boundaries of coexisting liquid-ordered (raft-like, l o ) and liquid-disordered (l d ) domains of more-component model membrane systems, hydrophobic mismatch and local curvature stress 45-48 may provide driving forces for the partitioning process. During the last years it has also become clear that the existence of lateral heterogeneities or domains in membranes is essential for a number of cellular functions.…”

Section: Line Tension Effects At Domain Boundaries and Lipid Sorting mentioning

confidence: 99%

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins

et al. 2013

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In a combined chemical-biological and biophysical approach we explored the Gibbs (free) energy contributions to the membrane partitioning of lipidated proteins, and compared the theoretical predictions with recent experimental data on the membrane insertion of Ras proteins of various anchor systems into rationally designed model biomembrane systems. Various factors fostering or reducing the membrane partitioning properties are discussed, including hydrophobic effects, lipid chain mismatch, electrostatic interactions, membrane-mediated protein-protein interactions, and terms that account for line tension effects between coexisting lipid domains, lipid sorting, and changes in the lateral organization of the lipid bilayer system. From these data, it is apparent that two membrane anchoring motifs are needed to facilitate firm membrane binding. For heterogeneous membranes, localization and sequestration at domain boundaries as well as formation of protein clusters and collective lateral organization via an effective lipid sorting mechanism provide complementary ways of inducing membrane nanodomains that could potentially operate as effective, high fidelity signalling platforms.

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Section: Line Tension Effects At Domain Boundaries and Lipid Sorting mentioning

confidence: 99%

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins

et al. 2013

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“…1. [32][33][34][35][36] When the membrane has even more excess area, larger shape changes can occur, as in d5-d8 of Fig. 1.…”

Section: Fluorescence Microscopy To Identify Liquid Phasesmentioning

confidence: 99%

Hallmarks of Reversible Phase Separation in Living, Unperturbed Cell Membranes

Rayermann

Merz

et al. 2017

Biophysical Journal

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“…The force that produces membrane bending in this case is the line tension g at domain interfaces, which results from misalignments (e.g., curvature or height mismatches) that cause hydrophobic acyl chain segments to be exposed to bulk water molecules or hydrophilic head groups from neighboring lipids ( Fig. 4A) (Semrau and Schmidt 2009;Johannes and Mayor 2010). An example is long acyl chain glycosphingolipids (GSLs) that are clustered by bacterial toxins to form a domain that is thicker than the bulk membrane (Römer et al 2007).…”

Section: Line Tensionmentioning

confidence: 99%

Bending "On the Rocks"--A Cocktail of Biophysical Modules to Build Endocytic Pathways

Johannes

Wunder

Bassereau

2014

Cold Spring Harbor Perspectives in Biology

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Numerous biological processes rely on endocytosis. The construction of endocytic pits is achieved by a bewildering complexity of biochemical factors that function in clathrin-dependent and -independent pathways. In this review, we argue that this complexity can be conceptualized by a deceptively small number of physical principles that fall into two broad categories: passive mechanisms, such as asymmetric transbilayer stress, scaffolding, line tension, and crowding, and active mechanisms driven by mechanochemical enzymes and/or cytoskeleton. We illustrate how the functional identity of biochemical modules depends on system parameters such as local protein density on membranes, thus explaining some of the controversy in the field. Different modules frequently operate in parallel in the same step and often are shared by apparently divergent uptake processes. The emergence of a novel endocytic classification system may thus be envisioned in which functional modules are the elementary bricks.

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Membrane heterogeneity – from lipid domains to curvature effects

Cited by 102 publications

References 207 publications

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins

Hallmarks of Reversible Phase Separation in Living, Unperturbed Cell Membranes

Bending "On the Rocks"--A Cocktail of Biophysical Modules to Build Endocytic Pathways

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