Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine

Greenwalt, Dale E.; Lipsky, Robert H.; Ockenhouse, CF; Ikeda, Hisami; Tandon, NN; Ga, Jamieson

doi:10.1182/blood.v80.5.1105.1105

Cited by 401 publications

(119 citation statements)

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“…The nonglycosylated form of this protein was found to have a molecular mass of 54 kDa. This protein was designated as FAT, and its cloning (from rat) revealed a high degree of amino acid homology (85%) with human platelet glycoprotein IV, also referred to as CD36 (19), suggesting that these proteins are species homologs (20). CD36 is supposed to be involved in platelet aggregation and signal transduction (19).…”

Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

“…This protein was designated as FAT, and its cloning (from rat) revealed a high degree of amino acid homology (85%) with human platelet glycoprotein IV, also referred to as CD36 (19), suggesting that these proteins are species homologs (20). CD36 is supposed to be involved in platelet aggregation and signal transduction (19). Besides its presence in platelets and endothelial cells (19), FAT/CD36 mRNA is expressed in tissues with a high lipid-metabolizing capacity such as heart, oxidative muscle and fat, but is absent in liver, brain, and kidney (20)(21)(22).…”

Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

“…CD36 is supposed to be involved in platelet aggregation and signal transduction (19). Besides its presence in platelets and endothelial cells (19), FAT/CD36 mRNA is expressed in tissues with a high lipid-metabolizing capacity such as heart, oxidative muscle and fat, but is absent in liver, brain, and kidney (20)(21)(22). Differentiation of preadipocytes into adipocytes showed an induction of FAT which was paralleled with an increase in FA uptake (20).…”

Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

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Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins

Luiken

Schaap

Nieuwenhoven

et al. 1999

Lipids

108

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Despite the importance of long-chain fatty acids (FA) as fuels for heart and skeletal muscles, the mechanism of their cellular uptake has not yet been clarified. There is dispute as to whether FA are taken up by the muscle cells via passive diffusion and/or carrier-mediated transport. Kinetic studies of FA uptake by cardiac myocytes and the use of membrane protein-modifying agents have suggested the bulk of FA uptake is due to a protein component. Three membrane-associated FA-binding proteins were proposed to play a role in FA uptake, a 40-kDa plasma membrane FA-binding protein (FABPpm), an 88-kDa FA translocase (FAT/CD36), and a 60-kDa FA transport protein (FATP). In cardiac and skeletal myocytes the intracellular carrier for FA is cytoplasmic heart-type FA-binding protein (H-FABP), which likely transports FA from the sarcolemma to their intracellular sites of metabolism. A scenario is discussed in which FABPpm, FAT/CD36, and H-FABP, probably assisted by an albumin-binding protein, cooperate in the translocation of FA across the sarcolemma.

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Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

Section: Plasma Membrane Fabp (Fabppm)mentioning

confidence: 99%

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Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins

Luiken

Schaap

Nieuwenhoven

et al. 1999

Lipids

108

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“…4 CD36 is an 88-kDa membrane GP expressed on cap-illary and mammary endothelium, macrophages, erythroblasts, adipocytes, platelets, and other tissues. 5 Recent studies indicate that CD36 is a Class B scavenger receptor capable of interacting with types I and IV collagen, malaria-infected RBCs, oxidized low-density lipoprotein, long-chain fatty acids, and thrombospondin -1. 6 Some apparently healthy individuals lack CD36 on their monocytes and/or platelets.…”

mentioning

confidence: 99%

Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature

et al. 2002

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Isoimmunization against CD36 can cause neonatal isoimmune thrombocytopenia (NITP), refractoriness to platelet transfusions, and post-transfusion purpura. Immunization against this glycoprotein (GP) should be considered in patients with apparent alloimmune platelet disorders not explained by immunization against recognized platelet-specific alloantigens, especially in persons of African, Asian, and, possibly, Mediterranean ancestry.

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“…It is a member of a family of receptors which also includes SR-B1/CLA-1, an HDL receptor. [12][13][14] CD36 is expressed by monocyte/macrophages, 15 platelets, 16 microvascular endothelial cells, 17 and adipose tissue. 18 Like type A scavenger receptors, 19 CD36 recognizes a broad variety of ligands including OxLDL, 11,20 anionic phospholipids, 21 apoptotic cells, 22 thrombospondin (TSP), 23 collagen, 24 Plasmodium falciparum-infected erythrocytes, 25 and long-chain fatty acids.…”

mentioning

confidence: 99%

Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis

Nicholson

Han

Febbraio

et al. 2001

Annals of the New York Academy of Sciences

122

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Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation. Genetically engineered murine models have been used to elucidate the contribution of the different scavenger receptors, to identify specific ligands related to LDL modifications, and to assess the possible therapeutic ramifications of targeting scavenger receptors. We have demonstrated a major role for CD36 in macrophage foam cell development and subsequent lesion development in vivo. Absence of CD36 in an atherogenic Apo E null background resulted in a 70% decrease in total lesion area in Western diet‐fed mice. We have also made significant progress in our understanding of the regulation of expression of CD36 and have demonstrated that OxLDL can stimulate its own uptake by induction of CD36 gene expression. The mechanism by which OxLDL upregulates CD36 involves activation of the transcription factor, PPAR‐γ.

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Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine

Cited by 401 publications

References 0 publications

Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins

Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins

Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature

Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis

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