Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8

Morales-Martínez, Adriana; Bertrand, Brandt; Hernández-Meza, Juan M.; Garduño‐Juárez, Ramón; Silva-Sánchez, Jesús; Muñóz-Garay, Carlos

doi:10.1016/j.bpj.2022.07.018

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Cited by 5 publications

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“…This change in Δ G mix suggested that the insertion of M5-NH 2 into these monolayers had increased their lipid packing and decreased their fluidity, which is consistent with the peptide's deep insertion into the P. aeruginosa CM 40,41 (Table 2) as reported for other AMPs. 59–63…”

Section: Resultsmentioning

confidence: 99%

“…This change in DG mix suggested that the insertion of M5-NH 2 into these monolayers had increased their lipid packing and decreased their fluidity, which is consistent with the peptide's deep insertion into the P. aeruginosa CM 40,41 (Table 2) as reported for other AMPs. [59][60][61][62][63] To further investigate later steps in the membranolytic action of M5-NH 2 against P. aeruginosa, its interaction with model membranes formed from individual lipid components of the organism's CM was investigated (Table 1). 44,55 The peptide Fig.…”

Section: Resultsmentioning

confidence: 99%

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