Membrane Fluctuation Model for Understanding the Effect of Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback
Ashish Pandey,
Piotr Nowakowski,
Carlos Ureña Martin
et al.
Abstract:We investigated the role of ligand clustering and density
in the
activation of natural killer (NK) cells. To that end, we designed
reductionist arrays of nanopatterned ligands arranged with different
cluster geometries and densities and probed their effects on NK cell
activation. We used these arrays as an artificial microenvironment
for the stimulation of NK cells and studied the effect of the array
geometry on the NK cell immune response. We found that ligand density
significantly regulated NK cell activatio… Show more
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