Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma

Marukawa, Yohei; Nakamoto, Yasunari; Kakinoki, Kaheita; Tsuchiyama, Tomoya; Iida, Noriho; Kagaya, Takashi; Sakai, Yoshio; Naito, Makoto; Mukaida, Naofumi; Kaneko, Shuichi

doi:10.1038/cgt.2012.3

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…The metastatic risk increases significantly in patients with high post‐PLR values compared with those with low post‐PLR values, indicating that suppressed immune function potentially contributes to metastasis. These findings suggest the potential use of a combination of antiplatelet therapy and immune‐modulated therapy for the prevention of metastasis in selected patients with advanced HCC after TACE. Similar to our observation, thrombocytosis was found to be significantly associated with advanced disease and shortened survival in ovarian cancer, and the use of an antiplatelet antibody in tumor‐bearing mice significantly reduced tumor growth and angiogenesis .…”

Section: Discussionmentioning

confidence: 99%

High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

Xue

et al. 2016

Hepatology Research

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Section: Discussionmentioning

confidence: 99%

High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

Xue

et al. 2016

Hepatology Research

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“…Most importantly the normal cells are not affected [25][26][27]. To date suicide gene therapy has been investigated in: a) liver [9,28,29], b) colon [8,30,31], c) neuroendocrine [32], d) lung [33,34], e) medulloblastomas [35], f) spinal cord tumors [36], g) prostate [37], h) breast [38,39], i) bladder [40], j) brain [41], k) head and neck [42], l) gliomas [43][44][45] and m) sarcomas [46]. It has been observed that suicide gene therapy is efficient in chemotherapy resistant cancer cell lines [47] and can enhance radiotherapy [48].…”

Section: Ivyspringmentioning

confidence: 99%

Gene Therapy for Hepatocellular Carcinoma: An Update

Kosmıdis¹,

Koimtzis²,

Pantos³

et al. 2019

J. Biomed

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Current statistics indicate that hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related death. Major predisposing conditions are hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. To date treatment approach includes liver transplantation, surgical resection and or ablation, however; recurrence, metastasis, and mortality still remains high. Therefore, alternative treatments such as gene therapy is increasingly being considered as a feasible proposal. In this mini review we will focus on novel data of the past 10 years on the subject of gene therapy and hepatocellular carcinoma.

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“…al. [27] were the herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) was combined with monocyte chemo-attractant protein-1 (MCP-1). Additionally a recombinant adenovirus vector (rAd) harboring human MCP-1 gene and the membrane-spanning domain of the Chemokine (C-X3-C motif) ligand 1 (CX3CL1) gene were used.…”

Section: Basic Strategies To Induce Cancer Cell Suicidementioning

confidence: 99%

“…The normal cells are not affected [21-23]. The suicide gene therapy has been investigated in several cancer types; a) colon [8,24,25], b) liver [9,26,27], c) lung [28,29], d) medulloblastomas [30], e) neuroendocrine [31], f) spinal cord tumors [32], g) prostate [33], h) breast [34,35], i) bladder [36], j) brain [37], k) gliomas [38-40], l) head and neck [41], m) sarcomas [42], and ovaries [108,111-112]. The suicide gene therapy has been investigated as; a) anti-vascular endothelial treatment [43,44], b) immune stimulation with interleukin- 7 (IL-7) [45] and interleukin-12 (IL-12) [46].…”

Section: Introductionmentioning

confidence: 99%

Suicide Gene Therapy for Cancer; Old Dog New Tricks

Zarogoulidis

Darwiche

Sakkas³

et al. 2013

J Genet Syndr Gene Ther

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Current cancer treatments may create profound iatrogenic outcomes. The adverse effects of these treatments still remain, as the serious problems that practicing physicians have to cope with in clinical practice. Although, non-specific cytotoxic agents constitute an effective treatment modality against cancer cells, they also tend to kill normal, quickly dividing cells. On the other hand, therapies targeting the genome of the tumors are both under investigation, and some others are already streamlined to clinical practice. Several approaches have been investigated in order to find a treatment targeting the cancer cells, while not affecting the normal cells. Suicide gene therapy is a therapeutic strategy, in which cell suicide inducing transgenes are introduced into cancer cells. The two major suicide gene therapeutic strategies currently pursued are: cytosine deaminase/5-fluorocytosine and the herpes simplex virus/ganciclovir. The novel strategies include silencing gene expression, expression of intracellular antibodies blocking cells’ vital pathways, and transgenic expression of caspases and DNases. We analyze various elements of cancer cells’ suicide inducing strategies including: targets, vectors, and mechanisms. These strategies have been extensively investigated in various types of cancers, while exploring multiple delivery routes including viruses, non-viral vectors, liposomes, nanoparticles, and stem cells. We discuss various stages of streamlining of the suicide gene therapy into clinical oncology as applied to different types of cancer. Moreover, suicide gene therapy is in the center of attention as a strategy preventing cancer from developing in patients participating in the clinical trials of regenerative medicine. In oncology, these clinical trials are aimed at regenerating, with the aid of stem cells, of the patients’ organs damaged by pathologic and/or iatrogenic factors. However, the stem cells carry the risk of neoplasmic transformation. We discuss cell suicide inducing strategies aimed at preventing stem cell-originated cancerogenesis.

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Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma

Cited by 9 publications

References 32 publications

High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

Gene Therapy for Hepatocellular Carcinoma: An Update

Suicide Gene Therapy for Cancer; Old Dog New Tricks

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