Membrane-Based Solvent Extraction

Prasad, Ravi; Sirkar, Kamalesh K.

doi:10.1007/978-1-4615-3548-5_41

Cited by 91 publications

(83 citation statements)

References 34 publications

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“…To analyze the effect of flow rates of both aqueous and organic streams on the mass transfer, K w is modeled as a sum of mass-transfer resistances (Prasad and Sirkar, 1992;Tompkins, 1993;Yeh and Huang, 1995) as follows…”

Section: Mass-transfer Model Of a Membrane Contactormentioning

confidence: 99%

Kinetic resolution of chiral amines with ω‐transaminase using an enzyme‐membrane reactor

Shin

Kim

Liese

et al. 2001

Biotech & Bioengineering

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A kinetic resolution process for the production of chiral amines was developed using an enzyme-membrane reactor (EMR) and a hollow-fiber membrane contactor with (S)-specific omega-transaminases (omega-TA) from Vibrio fluvialis JS17 and Bacillus thuringiensis JS64. The substrate solution containing racemic amine and pyruvate was recirculated through the EMR and inhibitory ketone product was selectively extracted by the membrane contactor until enantiomeric excess of (R)-amine exceeded 95%. Using the reactor set-up with flat membrane reactor (10-mL working volume), kinetic resolutions of alpha-methylbenzylamine (alpha-MBA) and 1-aminotetralin (200 mM, 50 mL) were carried out. During the operation, concentration of ketone product, i.e., acetophenone or alpha-tetralone, in a substrate reservoir was maintained below 0.1 mM, suggesting efficient removal of the inhibitory ketone by the membrane contactor. After 47 and 32.5 h of operation using 5 U/mL of enzyme, 98.0 and 95.5% ee of (R)-alpha-MBA and (R)-1-aminotetralin were obtained at 49.5 and 48.8% of conversion, respectively. A hollow-fiber membrane reactor (39-mL working volume) was used for a preparative-scale kinetic resolution of 1-aminotetralin (200 mM, 1 L). After 133 h of operation, enantiomeric excess reached 95.6% and 14.3 g of (R)-1-aminotetralin was recovered (97.4% of yield). Mathematical modeling of the EMR process including the membrane contactor was performed to evaluate the effect of residence time. The simulation results suggest that residence time should be short to maintain the concentration of the ketone product in EMR sufficiently low so as to decrease conversion per cycle and, in turn, reduce the inhibition of the omega-TA activity.

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Section: Mass-transfer Model Of a Membrane Contactormentioning

confidence: 99%

Kinetic resolution of chiral amines with ω‐transaminase using an enzyme‐membrane reactor

Shin

Kim

Liese

et al. 2001

Biotech & Bioengineering

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“…The parameter b is a flow-dependent parameter, which is chosen for achieving the best straight line [19,20,35]. By eliminating the chemical reaction resistance, the diffusion model can be adapted to the microcontactor geometry.…”

Section: Transport Of Zn(ii) In a Membrane-based Microcontactormentioning

confidence: 99%

“…This non-dispersive approach has several advantages over traditional dispersion-based extraction equipment (e.g. columns, mixer-settler), as it was discussed earlier for hollow fiber membrane contactors in [19,20]: independent regulation of the phase ratio over a broad range without flooding at high or unloading at low flow rates, no phase separation/density difference necessary, interfacial area is known and constant, low solvent holdup and no moving parts. However, an additional mass transfer resistance is introduced into the system by the membrane, which has a finite lifetime due to scaling and fouling [19].…”

Section: Introductionmentioning

confidence: 95%

“…Because of the negligible solubility of metal ions in organic solvents and the strong surface activity of D2EHPA, the reaction is assumed to occur at the interface [26,30], where the dimeric extractant adsorbs [29] and releases two protons into the aqueous phase. The (average) overall mass transfer coefficient K w (based on the aqueous phase) was experimentally calculated [20] by the following equation:…”

Section: Transport Of Zn(ii) In a Membrane-based Microcontactormentioning

confidence: 99%

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Reactive mass transfer in a membrane-based microcontactor

Willersinn

Bart

2015

Chemical Engineering and Processing: Process Intensification

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“…The theory of membrane-based solvent extraction is well developed [9]. Transfer of the solute species from the feed to the solvent phase through the membrane is described by an overall mass transfer coefficient.…”

Section: Introductionmentioning

confidence: 99%