“…Several effective methods have been developed for Zn 2+ determination, including atomic absorption spectroscopy, 16 gamma spectrometry, 17 immunochromatographic assay, 18 inductively coupled plasma mass spectrometry (ICP-MS), 19 inductively coupled plasma optical emission spectroscopy (ICP-OES), 20 atomic fluorescence spectrometry, 21 stripping voltammetry, [22][23][24] differential pulse voltammetry, 25 potentiometric methods, 22,26,27 chronopotentiometry analysis, 28 light scattering, 29 laser-induced breakdown spectroscopy, 30 laser desorption/ionization mass spectrometry (LDI-MS) 31 and chro-matographic techniques (HPLC). 32 Even though these methods provide high sensitivity and selectivity for Zn 2+ monitoring, they are also limited for point of care (POC) testing owing to their large size and higher cost of analysis and time.…”