Membrane applications for antibiotics production

Schroën, C.G.P.H.; Roon, J.L. van; Beefink, H.H.; Tramper, J.; Boom, R.M.

doi:10.1016/j.desal.2007.10.053

Cited by 5 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optimisation problem is posed such that different target amoxicillin product concentrations are met while consumption of the valuable feedstock 6-APA (bulk price = 35-40 USD kg −1 ) is minimised. Minimising feedstock consumption in different cases can lead to possible process configurations where reagents and solvent are recycled following desired product (amoxicillin) crystallisation [23,24]. Although recycling options are not explicitly considered in this work, they have been demonstrated in the literature for β-lactam antibiotic synthesis with nanofiltration for by-product (PHPG) removal [25].…”

Section: Dynamic Optimisationmentioning

confidence: 99%

Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin

et al. 2019

View full text Add to dashboard Cite

Amoxicillin belongs to the β-lactam family of antibiotics, a class of highly consumed pharmaceutical products used for the treatment of respiratory and urinary tract infections, and is listed as a World Health Organisation (WHO) "Essential Medicine". The demonstrated batch enzymatic synthesis of amoxicillin is composed of a desired synthesis and two undesired hydrolysis reactions of the main substrate (6-aminopenicillanic acid (6-APA)) and amoxicillin. Dynamic simulation and optimisation can be used to establish optimal control policies to attain target product specification objectives for bioprocesses. This work performed dynamic modelling, simulation and optimisation of the batch enzymatic synthesis of amoxicillin. First, kinetic parameter regression at different operating temperatures was performed, followed by Arrhenius parameter estimation to allow for non-isothermal modelling of the reaction network. Dynamic simulations were implemented to understand the behaviour of the design space, followed by the formulation and solution of a dynamic non-isothermal optimisation problem subject to various product specification constraints. Optimal reactor temperature (control) and species concentration (state) trajectories are presented for batch enzymatic amoxicillin synthesis.Processes 2019, 7, 318 2 of 17 worldwide [11]. The demonstrated enzymatic synthesis of amoxicillin paves the way for the elucidation of optimal design and operating parameters via modelling and optimisation [12,13].Dynamic modelling and optimisation of batch processes have been substantially implemented in the literature for a variety of bioprocesses, including fermentations [14,15], antibiotic synthesis [16,17] and many other applications, illustrating the utility and versatility of such methods in bioprocess design. Enzymatic synthesis, crystallisation and reactive crystallisation studies for β-lactam antibiotics have been implemented in the literature [16][17][18][19]. A demonstrated batch enzymatic synthesis of amoxicillin paves the way for theoretical studies [20]. Dynamic modelling and optimisation of the batch enzymatic synthesis of amoxicillin has yet to be implemented. Moreover, introducing temperature dependence into the model may allow for the optimisation of batch reactor temperature profiles to meet a specific production objective, which, to the best of our knowledge, has not been previously implemented.Processes 2019, 7, x FOR PEER REVIEW 2 of 17

show abstract

Section: Dynamic Optimisationmentioning

confidence: 99%

Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Physico-chemical studies have made it possible to design a highly efficient technological process to produce cefazolin [8]. Synthesis of various antibiotics by different enzymes immobilized on different supports has been achieved [85,86]. Stabilized enzymes are of great value in the processing and analysis of food samples.…”

Section: Practical Applications For Stabilized Enzymesmentioning

confidence: 99%

Enzyme stabilization by nano/microsized hybrid materials

Hwang

2012

Engineering in Life Sciences

403

208

View full text Add to dashboard Cite

Immobilization is a key technology for successful realization of enzyme‐based industrial processes, particularly for production of green and sustainable energy or chemicals from biomass‐derived catalytic conversion. Different methods to immobilize enzymes are critically reviewed. In principle, enzymes are immobilized via three major routes (i) binding to a support, (ii) encapsulation or entrapment, or (iii) cross‐linking (carrier free). As a result, immobilizing enzymes on certain supports can enhance storage and operational stability. In addition, recent breakthroughs in nano and hybrid technology have made various materials more affordable hosts for enzyme immobilization. This review discusses different approaches to improve enzyme stability in various materials such as nanoparticles, nanofibers, mesoporous materials, sol–gel silica, and alginate‐based microspheres. The advantages of stabilized enzyme systems are from its simple separation and ease recovery for reuse, while maintaining activity and selectivity. This review also considers the latest studies conducted on different enzymes immobilized on various support materials with immense potential for biosensor, antibiotic production, food industry, biodiesel production, and bioremediation, because stabilized enzyme systems are expected to be environmental friendly, inexpensive, and easy to use for enzyme‐based industrial applications.

show abstract

“…The removal of phenylacetic acid by several means facilitated the next reaction step, a conversion of 6-APA with an activated substrate to a semisynthetic β-lactam antibiotic, which is usually severely inhibited in the presence of phenylacetic acid. [39][40][41][42][43] ISPR is particularly interesting when hydrolases are used in the synthetic direction, because here the enzymes have to operate against the thermodynamic equilibrium if they are in an aqueous phase. This can be achieved under reverse hydrolysis conditions in a thermodynamically controlled reaction or by exploiting the transferase activity of hydrolases in a process under kinetic control.…”

Section: Class 3 Hydrolasesmentioning

confidence: 99%

In situ Product Recovery Integrated with Biotransformations

Bechtold¹,

Panke²

2009

Chimia

View full text Add to dashboard Cite

Biocatalysis constitutes an effective tool for the production of fine chemicals. In order to widen the spectrum of applicable reaction types to reactions that are constrained by inhibitions, product toxicity, or degradation, an unfavorable position of the thermodynamic equilibrium, or by kinetic control, in situ product removal (ISPR) is an attractive process option to overcome those limitations. To fully exploit the benefits of the ISPR approach, selective removal of the product to an auxiliary phase with high capacity is usually required. Obviously, such an operation becomes increasingly difficult with decreasing differences in the physical properties of substrate(s) and product(s) as it is arguably frequently the case with biotransformations. In this paper we analyze the possibilities to apply ISPR to biotransformations and identify the most promising developments supported by simple model considerations to fully exploit the potential of ISPR.

show abstract

Membrane applications for antibiotics production

Cited by 5 publications

References 12 publications

Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin

Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin

Enzyme stabilization by nano/microsized hybrid materials

In situ Product Recovery Integrated with Biotransformations

Contact Info

Product

Resources

About