Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats

Dias, Caroline Pietá; Lima, Maria Noêmia Martins de; Presti-Torres, Juliana; Dornelles, Arethuza; Garcia, Vanessa Athaíde; Scalco, Felipe Siciliani; Guimarães, Marcelo R.; Constantino, Larissa; Budni, Patrícia; Dal‐Pizzol, Felipe; Schröder, Nadja

doi:10.1016/j.neuroscience.2007.03.018

Cited by 119 publications

(59 citation statements)

References 66 publications

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“…Twenty-four hours after open field exploration, rats were trained and tested in a novel object recognition task as reported previously [56]. Training in the object recognition task took place in the same area used for the open field exploration.…”

Section: Methodsmentioning

confidence: 99%

Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

et al. 2011

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The translocation of synaptic Zn2+ to the cytosolic compartment has been studied to understand Zn2+ neurotoxicity in neurological diseases. However, it is unknown whether the moderate increase in Zn2+ in the cytosolic compartment affects memory processing in the hippocampus. In the present study, the moderate increase in cytosolic Zn2+ in the hippocampus was induced with clioquinol (CQ), a zinc ionophore. Zn2+ delivery by Zn-CQ transiently attenuated CA1 long-term potentiation (LTP) in hippocampal slices prepared 2 h after i.p. injection of Zn-CQ into rats, when intracellular Zn2+ levels was transiently increased in the CA1 pyramidal cell layer, followed by object recognition memory deficit. Object recognition memory was transiently impaired 30 min after injection of ZnCl2 into the CA1, but not after injection into the dentate gyrus that did not significantly increase intracellular Zn2+ in the granule cell layer of the dentate gyrus. Object recognition memory deficit may be linked to the preferential increase in Zn2+ and/or the preferential vulnerability to Zn2+ in CA1 pyramidal neurons. In the case of the cytosolic increase in endogenous Zn2+ in the CA1 induced by 100 mM KCl, furthermore, object recognition memory was also transiently impaired, while ameliorated by co-injection of CaEDTA to block the increase in cytosolic Zn2+. The present study indicates that the transient increase in cytosolic Zn2+ in CA1 pyramidal neurons reversibly impairs object recognition memory.

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Section: Methodsmentioning

confidence: 99%

Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

et al. 2011

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“…While the age groups did not differ behaviorally when the objects were distinctive, old rats were impaired on recognition performance relative to young animals when the objects to be distinguished shared multiple common features, even at very short delays (see also Pitsikas et al, 2005; Pieta Dias et al, 2007; Pitsikas and Sakellaridis, 2007: Hopkins et al, 2011). Burke et al (2010) further demonstrate that the age-related object discrimination impairment is not due to forgetting over the delay period, but rather a failure to represent the objects at a sufficient level of complexity.…”

Section: Introductionmentioning

confidence: 93%

Age‐related impairment in a complex object discrimination task that engages perirhinal cortex

et al. 2012

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Previous lesion studies have shown compromised complex object discrimination in rats, monkeys and human patients with damage to the perirhinal cortical region (PRC) of the medial temporal lobe. These findings support the notion that the PRC is involved in object discrimination when pairs of objects have a high degree of overlapping features but not when object discrimination can be resolved on the basis of a single feature (e.g., size or color). Recent studies have demonstrated age-related functional changes to the PRC in animals (rats and monkeys) resulting in impaired complex object discrimination and object recognition. To date, no studies have compared younger and older humans using paradigms previously shown to engage the PRC. To investigate the influence of age on complex object discrimination in humans, the present study used an object matching paradigm for blob-like objects that have previously been shown to recruit the PRC. Difficulty was manipulated by varying the number of overlapping features between objects. Functional MRI data was acquired to determine the involvement of the PRC in the two groups during complex object discrimination. Results indicated that while young and older adults performed similarly on the easy version of the task, most older adults were impaired relative to young participants when the number of overlapping features increased. fMRI results suggest that older adults do not engage bilateral anterior PRC to the same extent as young adults. Specifically, complex object matching performance in older adults was predicted by the degree to which they engage left anterior PRC. These results provide evidence for human age-related changes in PRC function that impact complex object discrimination.

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“…No teste do Campo Aberto (Open Field) foi utilizada uma arena dividida em 12 quadrantes. O animal era colocado na porção central e as seguintes variáveis comportamentais eram registradas durante 5 minutos: período de imobilidade; número de ambulações na periferia (áreas com paredes laterais); número de ambulações no centro (áreas sem contato com paredes laterais); número de elevações das patas traseiras (rearings) e tempo de autolimpeza (grooming) [22,23]. …”

Section: Métodosunclassified

Avaliação comportamental de ratos treinados em natação forçada

Peretti

Rosa

Errero

et al. 2015

Sci Med

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RESUMOObjetivos: O exercício físico regular tem diversos efeitos benéficos, contudo, há relatos de aumento na concentração de corticosteroides endógenos, os quais podem inibir a neurogênese e piorar as funções cognitivas, sendo este um aspecto dúbio do exercício físico. O objetivo deste estudo foi avaliar, por meio de testes comportamentais, o efeito do exercício crônico por natação forçada com e sem sobrecarga, sobre parâmetros de ansiedade em ratos Wistar. Métodos: Foram utilizados 24 ratos Wistar, separados em três grupos: Grupo Controle -submetido apenas a avaliações e contato com a água; Grupo Natação -composto por animais submetidos à natação com tempo progressivo; Grupo Natação com Sobrecarga -composto por animais submetidos à natação com sobrecarga de 10% do peso corporal. O exercício ocorreu três vezes por semana, no período vespertino, com aumento no tempo a cada duas semanas (20, 30 e 40 minutos), totalizando seis semanas. Foi realizado em um tanque de água circular de 200 litros, com profundidade de 50 cm e temperatura da água mantida entre 30 e 32º C. A ansiedade dos animais foi avaliada pelos testes Labirinto em Cruz Elevado e Campo Aberto. Resultados: Não houve diferenças significativas em qualquer dos testes comportamentais, comparando os três grupos. Conclusões: Não houve alteração no padrão comportamental de ratos Wistar submetidos a diferentes protocolos de exercício (natação forçada com e sem sobrecarga) quando comparados ao grupo controle não submetido a exercícios. DESCRITORES: comportamento animal; exercício; estresse psicológico. ABSTRACTAims: Regular exercise has several beneficial effects. However, reports show increasing concentrations of endogenous corticosteroids, which may inhibit neurogenesis and deteriorate cognitive functions, thus raising doubts as to the benefits of physical exercise. The objective of this study was to evaluate, through behavioral tests, the effect of chronic forced swimming with and without overload on anxiety parameters in Wistar rats. Methods: Twenty-four Wistar rats, divided into three groups, were assessed: Control Group -subjected only to evaluations and contact with water; Swimming Group -consisting of animals submitted to progressive swimming time; Weight-loaded Swimming Group -consisting of animals submitted to swimming with loads in excess of 10% of their body weight. The exercise was performed three times a week in the afternoon, with swimming time increases every two weeks (20, 30, and 40 minutes), during six weeks, A 200-liter circular water tank, filled to a depth of 50 cm, was used, and the water temperature was kept between 30º and 32º C. The animals' anxiety was assessed by the Elevated Plus Maze and Open Field tests. Results: No significant differences between the three groups were detected by any of the behavioral tests. Conclusions: No changes were observed in the behavioral pattern of Wistar rats submitted to different exercise protocols (forced swimming with and without overload) compared to the control group.KEY WORDS: behavior, animal; e...

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Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats

Cited by 119 publications

References 66 publications

Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

Age‐related impairment in a complex object discrimination task that engages perirhinal cortex

Avaliação comportamental de ratos treinados em natação forçada

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