Melt electrospinning writing as a method to form novel hydrogel architectures and constructs

Haigh, Jodie N.

doi:10.5204/thesis.eprints.103849

Cited by 2 publications

(3 citation statements)

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“…More recently, melt electrospinning writing (MEW) has attracted increasing attention due to its ability to deposit well-defined meshes with filament sizes ranging from few micrometers down to sub-micron levels 23,24 . MEWenabled sacrificial printing to generate microvascular networks has also been reported 25 . To further demonstrate the utility of our shrinking method, we manufactured MEW-printed polycaprolactone (PCL) grids ( Supplementary Fig.…”

Section: Resultsmentioning

confidence: 97%

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Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

et al. 2020

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Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

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Section: Resultsmentioning

confidence: 97%

“…Alternatively, PCL meshes were fabricated by the MEW technique and used as sacrificial templates 25 and 2.0 w/v% HAMA was cast around the templates. To leach the PCL template from the HAMA constructs, a multi-stage removal process was optimized.…”

Section: Methodsmentioning

confidence: 99%

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

et al. 2020

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“…It is commonly seen in multilayer melt electrospinning (and other additive manufacturing methods) that fibres spun in lattice formations tend to sometimes deform/sag in the direction of gravity between intersection points. This could be caused by either a slow cooling rate of the polymer, large distances between intersection points, or a combination of the two [ 65 , 68 ].…”

Section: State Of the Art—impact Of Apparatus Orientation In Electmentioning

confidence: 99%

Impact of Apparatus Orientation and Gravity in Electrospinning—A Review of Empirical Evidence

2020

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Electrospinning is a versatile fibre fabrication method with applications from textile to tissue engineering. Despite the appearance that the influencing parameters of electrospinning are fully understood, the effect of setup orientation has not been thoroughly investigated. With current burgeoning interest in modified and specialised electrospinning apparatus, it is timely to review the impact of this seldom-considered parameter. Apparatus configuration plays a major role in the morphology of the final product. The primary difference between spinning setups is the degree to which the electrical force and gravitational force contribute. Since gravity is much lower in magnitude when compared with the electrostatic force, it is thought to have no significant effect on the spinning process. But the shape of the Taylor cone, jet trajectory, fibre diameter, fibre diameter distribution, and overall spinning efficiency are all influenced by it. In this review paper, we discuss all these developments and more. Furthermore, because many research groups build their own electrospinning apparatus, it would be prudent to consider this aspect as particular orientations are more suitable for certain applications.

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Melt electrospinning writing as a method to form novel hydrogel architectures and constructs

Cited by 2 publications

References 1 publication

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Impact of Apparatus Orientation and Gravity in Electrospinning—A Review of Empirical Evidence

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