Meloxicam in acute UV dermatitis — a pilot study

Abstract

The non-steroidal anti-inflammatory drug (NSAID) meloxicam is a preferential cyclooxygenase-2 (COX-2) antagonist. The UV protective potential of this drug was studied to compare it with the reported beneficial effects of such preferentially COX-1 specific NSAIDs as indomethacin and acetylsalicylic acid in the literature. In a pilot study (open-label, non-randomized, non-controlled, unblinded), 10 patients received UV irradiation with the minimal erythema dose (MED), first with meloxicam (7.5 mg/die) to reduce post-operative pain and second without ingestion of meloxicam. The factor of UV protection was evaluated. In six of ten patients meloxicam showed no benefit, whereas four of ten patients had a 1.3- up to 3-fold UV protection. In this study, the benefit in UV protection of meloxicam as a preferential COX-2 antagonist was not above the reported benefit of the "old" COX-1 inhibiting NSAIDS.

Interaction of oxicam NSAIDs with DMPC vesicles: differential partitioning of drugs

“…Recently, oxicam group of non-steroidal antiinflammatory drugs (NSAIDs) have drawn much attention of the biochemists and chemists for their multifunctional potential (Hawkey, 1999;Sporn and Suh, 2000;Ritland and Gendler, 1999;Grossman et al, 2000;Goldman et al, 1998;Anderson et al, 1987;Serrano et al, 1992;Gebhardt and Wollina, 1995;Bayerl et al, 1998) and structural diversity (Yoon et al, 1998;Bordner et al, 1989;Geckle et al, 1989;Tsai et al, 1993;Redenti et al, 1999). The NSAIDs are the most common group of drugs used as painkillers and anti-inflammatory agents.…”

Determination of pKa values of nonsteroidal antiinflammatory drug‐oxicams by RP–HPLC and their analysis in pharmaceutical dosage forms

“…Piroxicam and tenoxicam are very good photosensitizers [9,10]. Meloxicam is not a photosensitizer, rather it is a photoprotector against UV light [11].…”

UV–Visible properties of oxicams in solution: A TD‐DFT and experimental study

“…In addition to the role as anti‐inflammatory drugs, chemoprevention5, 6 and chemosuppression functionalities have been investigated,7, 8 as well as their free radical scavenging abilities 9–11. Some NSAIDs are also good UV‐sensitizer12–14 and UV‐protector of skin,15 and side effects such as photoallergy have been observed for piroxicam 16. Photochemical properties of oxicams certainly are sensitive to the polarity and pH of the medium due to their acid–base and tautomeric behavior in solution, which involves various isomers participating in a complex set of prototropic microequilibria,17–19 see Figure 2.…”