Meloidogyne incognita population control and nutritional status and productivity of Thompson seedless grapevines managed with different treatments

Abdel-Sattar, Mahmoud; Haikal, Amr M.; Hammad, Sandy E.

doi:10.1371/journal.pone.0239993

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…We tested nementin-1’s interaction with the organophosphate dichlorvos against Strongyloides ratti , a nematode parasite of mammals. Dichlorvos is approved for anthelmintic use in mammals 39 , 40 . Indeed, we find that nementin-1 synergistically enhances dichlorvos’ activity against S. ratti (Fig.…”

Section: Resultsmentioning

confidence: 99%

Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

et al. 2022

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Nematode parasites of humans, livestock and crops dramatically impact human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and traditional nematicides that protect crops are facing increasing restrictions because of poor phylogenetic selectivity. Here, we exploit multiple motor outputs of the model nematode C. elegans towards nematicide discovery. This work yielded multiple compounds that selectively kill and/or immobilize diverse nematode parasites. We focus on one compound that induces violent convulsions and paralysis that we call nementin. We find that nementin stimulates neuronal dense core vesicle release, which in turn enhances cholinergic signaling. Consequently, nementin synergistically enhances the potency of widely-used non-selective acetylcholinesterase (AChE) inhibitors, but in a nematode-selective manner. Nementin therefore has the potential to reduce the environmental impact of toxic AChE inhibitors that are used to control nematode infections and infestations.

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Section: Resultsmentioning

confidence: 99%

Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

et al. 2022

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“…3F). Both dichlorvos and oxamyl are approved for field use ( 38, 39 ). The Nementins may therefore have added benefit against parasitic nematodes when used in combination with pesticides that are AChE inhibitors.…”

Section: Resultsmentioning

confidence: 99%

“…4f,g). Nementin-1 was also found to synergistically paralyze the plant-parasitic nematode Meloidogyne hapla with the carbamate AChE inhibitor oxamyl, which is approved for field use 39,40 (Fig. 4h,i).…”

Section: Resultsmentioning

confidence: 99%

Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release

Harrington

Knox

Burns

et al. 2022

Preprint

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Nematode parasites of humans, livestock and crops pose a significant burden on human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and traditional nematicides that protect crops are facing increasing restrictions because of poor phylogenetic selectivity. Here, we present a pipeline that exploits multiple motor outputs of the model nematode C. elegans for nematicide discovery. This pipeline yielded a compound, which we call Nementin, that selectively immobilizes diverse nematode parasites. We find that Nementin induces convulsions by agonizing neuronal dense core vesicle release, which in turn agonizes cholinergic signaling. Consequently, Nementin synergistically enhances the potency of acetylcholinesterase inhibitors that are restricted agrochemicals. Nementin therefore represents a novel candidate nematicide that may improve the selectivity of broad-acting pesticides.

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“…Plant parasitic nematodes consist of four larval stages and the adult female and male. M. incognita completes the first cycle within the egg, and in the second stage, it infects plant root and root-knots were formed and completed their remaining stages within 8 weeks [ 40 , 41 ]. El-Sheikh et al [ 42 ] isolated Paecilomyces sp.…”

Section: Discussionmentioning

confidence: 99%

Paecilomyces formosus MD12, a Biocontrol Agent to Treat Meloidogyne incognita on Brinjal in Green House

Baazeem

Alorabi

Palanisamy

et al. 2021

JoF

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The present study was carried out to analyze the potential of fungi isolated from the rhizosphere of soybean, brinjal, tomato, and potato plants. The density of fungi varied in the pot soil and rhizosphere after Paecilomyces formosus MD12 treatment. The P. formosus MD12 population was 6.3 ± 0.13 × 104 CFU g−1 in the pot planted with brinjal, and the population increased in the rhizosphere (6.72 ± 0.41 × 104 CFU g−1). P. formosus MD12 was cultured in the production medium, and the supernatant was used for egg inhibition studies on a root-knot nematode parasite, Meloidogyne incognita. It was revealed that maximum egg inhibition (94.7 ± 6.2%) was obtained at 100% concentration of extract. The culture supernatant from P. formosus MD12 affected the development of M. incognita juvenile, and the mortality rate was maximum after 96 h (95 ± 6%). Mortality was reduced when treated with 25%, 50%, and 75% supernatant. At 1 × 107 mL−1 of spore suspension, we found reductions of 71.6 ± 3.3% nematode populations in the soil, 60.7 ± 2.2% from the root, and 63.6 ± 2.4% egg mass compared with the control in the pot experiment. The culture supernatant applied at the 10% level showed a maximum mean reduction of the nematode population in roots (72.4 ± 2.2%), soil (77.9 ± 2.5%), and egg masses (73.2 ± 1.5%), respectively. The presence of P. formosus MD12 in a soil environment could antagonize nematode parasites and improve soil amendment. The P. formosus MD12 strain showed good biocontrol ability against the root-knot nematode, M. incognita, under in vitro and green house experimental condition.

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Meloidogyne incognita population control and nutritional status and productivity of Thompson seedless grapevines managed with different treatments

Cited by 11 publications

References 47 publications

Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release

Paecilomyces formosus MD12, a Biocontrol Agent to Treat Meloidogyne incognita on Brinjal in Green House

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