Melittin Inhibits Growth of Human Osteosarcoma 143B Cells through
Induction of Apoptosis <i>via</i> Suppressing the Wnt/β-catenin Signaling Pathway

Xie, Xiaoxiao; Li, Yumei; Zhu, Haixia; Chen, Lin; Chen, Deta; Lin, Shengming; Fan, Tao

doi:10.2174/1871520622666220509121627

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…BV and MEL suppress the activation of EGFR and HER2 in triple-negative and HER2-enriched breast cancer cells by interfering with the phosphorylation of these receptors in the plasma membrane [ 155 ]. Reports about the suppression of the Wnt/β-catenin pathway by MEL suggest the destruction of the Wnt receptors by the peptide [ 156 ].…”

Section: Anticancer Effects Of Bee Venom and Its Componentsmentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). Previous studies have indicated that BV and its major constituent MEL cause a strong toxic effect on different cancer cells, such as liver, lung, bladder, kidney, prostate, breast, and leukemia cells, while a less pronounced effect was observed in normal non-target cells. Their proposed mechanisms of action, such as the effect on proliferation and growth inhibition, cell cycle alterations, and induction of cell death through several cancer cell death mechanisms, are associated with the activation of phospholipase A2 (PLA2), caspases, and matrix metalloproteinases that destroy cancer cells. Numerous cellular effects of BV and MEL need to be elucidated on the molecular level, while the key issue has to do with the trigger of the apoptotic cascade. Apoptosis could be either a consequence of the plasmatic membrane fenestration or the result of the direct interaction of the BV components with pro-apoptotic and anti-apoptotic factors. The interaction of BV peptides and enzymes with the plasma membrane is a crucial step in the whole process. However, before its possible application as a remedy, it is crucial to identify the correct route of exposure and dosage of BV and MEL for potential therapeutic use as well as potential side effects on normal cells and tissues to avoid any possible adverse event.

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Section: Anticancer Effects Of Bee Venom and Its Componentsmentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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“…The MAPK/ERK signaling pathway is responsible for the regulation of cell division, cell cycle or transcription regulation in cancer cells ( Zhai et al, 2019 ). A recent study in 2022 confirmed that melittin could inhibit the growth of osteosarcoma 143B cells, which was associated with the supression of Wnt/β-catenin signaling pathway activity and cause apoptosis through up-regulating the ratio of Bax/Bcl-2 ( Xie et al, 2022 ).…”

Section: Mechanisms Of Amps Underlying Their Anti-cancer Effectsmentioning

confidence: 99%

Anticancer activities of natural antimicrobial peptides from animals

Qu,

Yuan,

Liu

et al. 2024

Front. Microbiol.

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Cancer is the most common cause of human death worldwide, posing a serious threat to human health and having a negative impact on the economy. In the past few decades, significant progress has been made in anticancer therapies, but traditional anticancer therapies, including radiation therapy, surgery, chemotherapy, molecular targeted therapy, immunotherapy and antibody-drug conjugates (ADCs), have serious side effects, low specificity, and the emergence of drug resistance. Therefore, there is an urgent need to develop new treatment methods to improve efficacy and reduce side effects. Antimicrobial peptides (AMPs) exist in the innate immune system of various organisms. As the most promising alternatives to traditional drugs for treating cancers, some AMPs also have been proven to possess anticancer activities, which are defined as anticancer peptides (ACPs). These peptides have the advantages of being able to specifically target cancer cells and have less toxicity to normal tissues. More and more studies have found that marine and terrestrial animals contain a large amount of ACPs. In this article, we introduced the animal derived AMPs with anti-cancer activity, and summarized the types of tumor cells inhibited by ACPs, the mechanisms by which they exert anti-tumor effects and clinical applications of ACPs.

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“…Probably the most intensively investigated property, however, remains the exploitation of the anticancer properties of melittin, both on its own and as possible compounds and nanoparticles. For example, in osteosarcoma, growth inhibition in a mouse model and in vitro in 148 B (human osteosarcoma) cells via induction of apoptosis through suppression of the Wnt/β-catenin signaling pathway has been described (104). Similarly, inhibition of MG63 (human osteosarcoma cell line) cell proliferation through activation of the apoptosis pathway mediated by endoplasmic reticulum (ER) stress has been demonstrated (105).…”

Section: Investigated Uses Of Bee Venom Compounds and Their Mechanism...mentioning

confidence: 99%

Bee Venom - Friend or Enemy

Pudelka,

Janovska,

Malis

et al. 2024

Mil. Med. Sci. Lett.

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Increasing resistance to antibiotics, adverse effects of standard anti-cancer or anti-inflammatory treatments, or tumour types resistant to these treatments are leading to a search for alternatives. One of these is the use of natural products, such as bee venom, which have the same or better effect than these standard products. Bee venom has been used to treat a number of diseases for thousands of years. However, a significant obstacle remains the risk of severe allergic reactions, which can be caused by some of the more than 100 substances contained in the venom. Therefore, intensive research is currently underway to investigate not only the actual use of bee venom or its components in the above areas, but also ways to prevent these adverse effects.

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Melittin Inhibits Growth of Human Osteosarcoma 143B Cells through Induction of Apoptosis via Suppressing the Wnt/β-catenin Signaling Pathway

Cited by 6 publications

References 40 publications

Bee Venom: Composition and Anticancer Properties

Bee Venom: Composition and Anticancer Properties

Anticancer activities of natural antimicrobial peptides from animals

Bee Venom - Friend or Enemy

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