Melittin enhanced intracellular trehalose with synergistic membrane stabilization of macromolecular protectants for cell cryopreservation

Niu, QingJing; Gao, ShuHui; Zhu, KongYing; Ren, LiXia; Yuan, XiaoYan

doi:10.1007/s11431-023-2484-4

Sci. China Technol. Sci.

2024

DOI: 10.1007/s11431-023-2484-4

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Melittin enhanced intracellular trehalose with synergistic membrane stabilization of macromolecular protectants for cell cryopreservation

QingJing Niu,

ShuHui Gao,

KongYing Zhu

et al.

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Development of Macromolecular Cryoprotectants for Cryopreservation of Cells

Yuan,

Chen,

Zhu

et al. 2024

Macromol. Rapid Commun.

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Cryopreservation is a common way for long‐term storage of therapeutical proteins, erythrocytes, and mammalian cells. For cryoprotection of these biosamples to keep their structural integrity and biological activities, it is essential to incorporate highly efficient cryoprotectants. Currently, permeable small molecular cryoprotectants such as glycerol and dimethyl sulfoxide dominate in cryostorage applications, but they are harmful to cells and human health. As acting in the extracellular space, membrane‐impermeable macromolecular cryoprotectants, which exert remarkable membrane stabilization against cryo‐injury and are easily removed post‐thaw, are promising candidates with biocompatibility and feasibility. Water‐soluble hydroxyl‐containing polymers such as poly(vinyl alcohol) and polyol‐based polymers are potent ice recrystallization inhibitors, while polyampholytes, polyzwitterions, and bio‐inspired (glyco)polypeptides can significantly increase post‐thaw recovery with reduced membrane damages. In this review, the synthetic macromolecular cryoprotectants are systematically summarized based on their synthesis routes, practical utilities, and cryoprotective mechanisms. It provides a valuable insight in development of highly efficient macromolecular cryoprotectants with valid ice recrystallization inhibition activity for highly efficient and safe cryopreservation of cells.

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Development of Macromolecular Cryoprotectants for Cryopreservation of Cells

Yuan,

Chen,

Zhu

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

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Melittin enhanced intracellular trehalose with synergistic membrane stabilization of macromolecular protectants for cell cryopreservation

Cited by 1 publication

References 38 publications

Development of Macromolecular Cryoprotectants for Cryopreservation of Cells

Development of Macromolecular Cryoprotectants for Cryopreservation of Cells

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