Melatonin versus chloral hydrate for recording sleep EEG

Ashrafi, Mahmoud Reza; Mohammadi, Mahmoud; Tafarroji, Javad; Shabanian, Reza; Salamati, Peyman; Zamani, Gholamreza

doi:10.1016/j.ejpn.2009.06.010

Cited by 47 publications

(65 citation statements)

References 19 publications

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“…Melatonin has previously been successfully utilised as an alternative to sedation in children undergoing magnetic resonance imaging examinations (MRI), as conventional sedation methods and/or general anaesthetic propose high failure rates as well as risk factors for this population. 22,15 The results of this study indicated that 65 % of the children who received melatonin fell asleep within 35 minutes of receiving the drug; and findings of this study also highlighted the positive outcomes of using melatonin, in terms of cost, age, patient safety and resuscitation facilities and equipment; which are factors associated with conventional sedation methods and/or general anaesthetic. 22 Some studies have reported the use of melatonin in combination with sedatives when sedating children undergoing MRI examinations.…”

Section: Introductionmentioning

confidence: 62%

“…· Participants had to not present with the documented medical contraindications of melatonin. 16,15,20,21 · Participants were required to have transport arrangements to ensure their safety from driving following assessment, should they have experienced any side-effects from melatonin which could affect their ability to drive.…”

Section: Participants Sample and Sampling Proceduresmentioning

confidence: 99%

“…6 Once the pre-melatonin ABR assessment was concluded, each participant received two 1.5 mg capsules of "Biogen Platinum Series Melatonin" and was requested to "lie-down and relax" in a darkened test room for a duration of 40 minutes prior to the post-melatonin ABR testing. Melatonin has been reported to require 20 -120 minutes to take-effect 15 and so 40 minutes was thought to be sufficient time for the purposes of the current study. Wave form analysis following Hall's 6 protocol, as detailed in Table 2, was conducted and data captured on an excel spread sheet for ease of data analysis.…”

Section: Abr Testing (Pre and Post-melatonin)mentioning

confidence: 99%

“…Nonetheless, the current authors are of the view that an extension of the findings to the pediatric population can possibly be supported by earlier reports on successful use of Melatonin as an alternative to sedation in children undergoing MRI. 15,22 The consequent benefits for patients, particularly from contexts where resources are limited, are significant. Patients would not need to be admitted as inpatients and pay for additional resources just to undergo an audiologic evaluation.…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

“…The current study aimed to determine if melatonin could be utilised successfully as a "sedative" during ABR recordings, in order to induce sleep or a relaxed state, and reduce and/or eliminate muscle artifacts which preclude efficient recording of the ABR. Melatonin requires 20 -120 minutes to take-effect and is reported to be non-toxic and does not normally cause negative side effects in healthy individuals 15 and children. 8 Moreover, clear contraindications for the use of the drug have been documented; 16 and additionally, medical monitoring is not required.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Shangase¹,

Mavrokordatos²

2013

J Pharm Sci Innov.

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The audiological use of the auditory brainstem response (ABR) to obtain diagnostic audiological information can be challenging in the "difficult-to-test" populations where sedation is required. This challenge becomes more pronounced in non-medical settings where medical personnel who can provide drug administration as well as monitor the patient while under sedation are not readily available. The non-medical setting comprises a big portion of audiology practices and clinics; hence the importance of exploring sedation protocols that can be used in this setting. The current study explored the use of melatonin as a "sedative" during ABR testing. Within a prospective pretest -posttest design, 27 adults with normal hearing comprised the study sample. All participants underwent basic audiologic testing comprising of otoscopy, tympanometry, and pure tone audiometry followed by an ABR which was conducted pre and post melatonin administration. The initial recording was conducted prior to the administration of melatonin with the second recording performed 40 minutes following the participants' intake of 3 milligrams of melatonin. Data was analysed using both qualitative and quantitative statistical measures. Findings indicated that melatonin can be successfully utilised as a * "sedative" during ABR testing as it allowed for statistically significant reduction in muscle artifacts, did not present negative impact on morphology, repeatability, amplitude and latency of the recordings; and also did not induce any obvious and/or reported negative effects for the participants. These findings have important clinical and training implications, particularly in resource-constrained contexts and in contexts where audiologists function within non-medical facilities.

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Section: Introductionmentioning

confidence: 62%

Section: Participants Sample and Sampling Proceduresmentioning

confidence: 99%

Section: Abr Testing (Pre and Post-melatonin)mentioning

confidence: 99%

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Shangase¹,

Mavrokordatos²

2013

J Pharm Sci Innov.

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Melatonin as add-on treatment for epilepsy

Brigo

Felice²

2012

Cochrane Database of Systematic Reviews

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Chloral hydrate as a sedating agent for neurodiagnostic procedures in children

Fong

Tay

Ong

et al. 2017

Cochrane Database of Systematic Reviews

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The quality of evidence for the comparisons of oral chloral hydrate against several other methods of sedation was very variable. Oral chloral hydrate appears to have a lower sedation failure rate when compared with oral promethazine for children undergoing paediatric neurodiagnostic procedures. The sedation failure was similar for other comparisons such as oral dexmedetomidine, oral hydroxyzine hydrochloride, and oral midazolam. When compared with intravenous pentobarbital and music therapy, oral chloral hydrate had a higher sedation failure rate. However, it must be noted that the evidence for the outcomes for the comparisons of oral chloral hydrate against intravenous pentobarbital and music therapy was of very low to low quality, therefore the corresponding findings should be interpreted with caution.Further research should determine the effects of oral chloral hydrate on major clinical outcomes such as successful completion of procedures, requirements for additional sedative agent, and degree of sedation measured using validated scales, which were rarely assessed in the studies included in this review. The safety profile of chloral hydrate should be studied further, especially the risk of major adverse effects such as bradycardia, hypotension, and oxygen desaturation.

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Melatonin versus chloral hydrate for recording sleep EEG

Cited by 47 publications

References 19 publications

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Melatonin as add-on treatment for epilepsy

Chloral hydrate as a sedating agent for neurodiagnostic procedures in children

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