Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis

Kireev, Roman; Bitoun, Samuel; Cuesta, Sara; Tejerina, A.; Ibarrola, Carolina; Moreno, Enrique; Vara, Elena; Tresguerres, Jesús A.F.

doi:10.1016/j.ejphar.2012.11.038

Cited by 62 publications

(51 citation statements)

References 61 publications

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“…As reported here, MLT's ability to reduce iNOS expression was also demonstrated in previous studies on induced oxidative stress in liver [42,61].…”

Section: Immunohistochemistry Of Inossupporting

confidence: 57%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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Abstract:Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24-and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

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“…As reported here, MLT's ability to reduce iNOS expression was also demonstrated in previous studies on induced oxidative stress in liver [42,61].…”

Section: Immunohistochemistry Of Inossupporting

confidence: 57%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

View full text Add to dashboard Cite

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“…The clamp was released after 35 min to recover the inflow of hepatic blood, and the abdomen was subsequently sutured. In the MT group, intraperitoneal injections of 10 mg/kg MT [1ml (ip)] were administered 35 and 70 min prior to ischemia, as well as at the early stage of reperfusion, and at 1 and 2 h post-reperfusion (7)(8)(9)(10)(11)(12).…”

Section: Methodsmentioning

confidence: 99%

Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury

Deng

Liu

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the effects of melatonin (MT) on liver function and lipid peroxidation following hepatic ischemia-reperfusion injury (IRI). A total of 66 male Sprague-Dawley rats were randomly assigned into three groups: Normal control (N) group, ischemia-reperfusion (IR) group and the MT-treated group. A hepatic IRI model was developed by blocking the first porta hepatis, and subsequently restoring hepatic blood inflow after 35 min. Following reperfusion, changes in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were detected by a chemical method at various time points. In the MT group, the MDA levels were significantly reduced (P<0.05) at all time points, as compared with the IR group. Furthermore, SOD activity was significantly increased (P<0.05) in the MT group, as compared with the IR group at all time points; and the levels of GSH in the MT group were significantly higher (P<0.05) than those of the IR group at 2, 4, and 8 h post-reperfusion. The levels of ALT, AST and LDH were significantly reduced in the MT group at each time point, as compared with that of the IR group (P<0.05). In conclusion, MT exhibits potent antioxidant properties that may create favorable conditions for the recovery of liver function following IRI. IntroductionIn order to effectively control bleeding during hepatobiliary surgery, hepatic portal occlusion is often used, as it can temporarily interrupt the portal vein and hepatic artery inflow. This method is widely accepted since it is clinically simple, practical and effective; however, there is an inherent risk of subsequent liver ischemia-reperfusion injury (IRI). Therefore, in recent years, clinical research in the field of hepatic surgery has focused on how to reduce blood loss and improve the safety of hepatic portal occlusion, whilst simultaneously reducing the risk of liver IRI.Previous studies investigating tissues and organs such as the brain, heart, kidney and retina have demonstrated that numerous free radicals are produced during IRI, when the endogenous radical scavengers cannot function appropriately, leading to cell damage (1,2). Therefore, investigating effective drugs that alleviate IRI-induced functional liver damage, and improve the postoperative survival rate, has become a research hotspot in the field of hepatic surgery. Melatonin (MT) is a neural endocrine hormone that is secreted by the pineal gland (PG), which exerts known antioxidant, antitoxic, anti-stress and anti-inflammatory effects (3,4). Previous studies have demonstrated that MT has a protective role in IRI of the brain, heart, kidney and retina (5); however, its protective effects in liver IRI and the underlying mechanism require further research. An animal model of hepatic portal occlusion was used in the present study. MT was administered in advance, and the influence and significance of MT on antioxidant capacity, lipid peroxidation ...

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“…Reports on the nature of the effects of melatonin on the production of activated oxygen metabolites and the body's antioxidant defense are ambiguous. On the one hand, there is a signifi cant number of reports demonstrating that melatonin has antioxidant properties [19,23]. However, there are also studies showing that melatonin makes an insignificant contribution to the body's antioxidant defense because of the low level of this hormone [5].…”

mentioning

confidence: 99%

Effects of Melatonin on Lipid Peroxidation in Blood in Rats with Different Behavioral Characteristics in Acute Emotional Stress

Перцов

Коплик

Kalinichenko

et al. 2015

Neurosci Behav Physi

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The formation of negative emotional states in response to stressors is among the most important of current problems. The wide spectrum of functional impairments in response to emotiogenic factors is evidence that the state of stress is a complex systematic reaction mounted by the body [14].The pathogenesis of stress-related dysfunction in mammals is tightly linked with the free radical processes of lipid peroxidation [1,20]. Disturbances to the ratio of prooxidants and antioxidants accompanied by changes in the intensity of oxidative-reductive reactions in biological membranes and fl uids may be a signal triggering the stress response.Experimental studies of emotional stress have identifi ed individual differences in the sensitivity of animals to developing the negative consequences of stress factors [14,22]. A reliable prognostic criterion for the resistance of rats to emotional stress is provided by their behavioral activity in the open fi eld test. In particular, active animals are prognosticated to be more resistant to stress factors than passive individuals [2].In relation to the defense of the body from stress-related impairments, the task is that of increasing individual stress resistance. There is potential in seeking endogenous biologically active substances with infl uences on the functional activity of the stress-mediating and stress-limiting systems in mammals. Melatonin is one such compound. In mammals, the main site of melatonin synthesis is the pineal body. In addition, melatonin production also takes place in the retina and ciliary body of the eye. Melatonin-producing cells are seen in different parts of the gastrointestinal tract, respiratory pathways, thyroid gland, thymus, adrenals, cerebellum, urogenital system, placenta, and other organs. Melatonin synthesis has also been detected in the immune and other neuroendocrine cells -mast cells, natural killer cells, eosinophils, platelets, and endotheliocytes. Current concepts of the nature of the synthesis and secretion, biological activity, and features of the actions of pineal and extrapineal melatonin have been discussed in detail elsewhere [6].The nature of the effects of melatonin on lipid peroxidation, assessed in terms of changes in thiobarbituric acid (TBA)-reactive products, were studied in the peripheral blood in behaviorally passive and active Wistar rats. The acute rat stress model consisted of 1-h restraint with electrocutaneous stimulation. I.p. injection of melatonin (2 mg/kg) produced virtually no change in the intensity of lipid peroxidation in plasma in passive animals but was followed by an increase in active animals. Specifi c features of free radical processes in the blood were seen after stress: suppression in passive rats and the absence of change in active individuals. Administration of melatonin promoted decreases in the intensity of lipid peroxidation in the blood of stressed rats as compared with control animals given neurohormone. Thus, the nature of the action of melatonin on free radical processes depended on their ini...

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Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis

Cited by 62 publications

References 61 publications

Action of Melatonin on Severe Acute Liver Failure in Rats

Action of Melatonin on Severe Acute Liver Failure in Rats

Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury

Effects of Melatonin on Lipid Peroxidation in Blood in Rats with Different Behavioral Characteristics in Acute Emotional Stress

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