Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

“…Among the patients who failed to become pregnant with a low fertilization rate (B50 %) in the previous in vitro fertilizationembryo transfer (IVF-ET) cycle, melatonin supplementation (3 mg/day) markedly improved fertilization rates compared to those for previous IVF-ET cycles and resulted in high pregnancy rates [60]. However, meta-analysis of randomized controlled trials with melatonin supplementation during COH for women undergoing ART could not conclusively demonstrate beneficial clinical outcomes, including those related to the number of oocytes retrieved, clinical pregnancy rates, and miscarriage rates [62]. Melatonin supplementation may improve the clinical outcomes of ART only in a subset of infertile patients.…”

Time‐lapse embryo imaging for improving reproductive outcomes: systematic review and meta‐analysis

“…Assisted reproductive techniques (ART) have been widely used to treat this condition for more than three decades; however, both clinical‐pregnancy and live‐birth rates are still considered suboptimal, at approximately 35% and 25% per started cycle, respectively. In order to improve the overall treatment efficiency, several interventions are currently being studied.…”

Determination of Complementary and Alternative Medicine Practices Used by Women Applying to Infertility Clinic

“…Ancak, melatoninin IVF sonuçları üzerine etkilerini araştıran 5 çalışmanın meta-analizinde anlamlı bir etkinlik gösterileme-miştir. 21 Bir diğer antioksidan özellikleri olan madde hayıt bitkisidir (vitex agnus-castus). Düşük dozlarda serum folikül stimüle edici hormon ve östra-diol düzeylerini azaltıp serum luteinizan hormon ve progesteron düzeylerini artırdığı, yüksek dozlarda prolaktini de azaltıcı etkisi olduğu bilinmektedir.…”