Melatonin Supplementation Alters Maternal and Fetal Amino Acid Concentrations and Placental Nutrient Transporters in a Nutrient Restriction Bovine Model

Swanson, Rebecca M; Contreras-Correa, Zully E; Dinh, Thu; King, Heath; Sidelinger, Darcie R; Burnett, D. D.; Lemley, Caleb O

doi:10.3390/metabo12121208

Cited by 3 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, there were no effects of melatonin on total branched-chain amino acids in these sheep [ 103 ]. Melatonin rescued the effects of nutrient restriction in total amino acids but not essential amino acids in late gestation cows receiving 20 mg of dietary melatonin daily in the fall [ 104 ]. In these same cows, amino acids were evaluated by a transport system in which melatonin also rescued the effects of nutrient restriction in System A, System N, and Anion amino acids [ 104 ].…”

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

“…Melatonin rescued the effects of nutrient restriction in total amino acids but not essential amino acids in late gestation cows receiving 20 mg of dietary melatonin daily in the fall [ 104 ]. In these same cows, amino acids were evaluated by a transport system in which melatonin also rescued the effects of nutrient restriction in System A, System N, and Anion amino acids [ 104 ]. Furthermore, fall-supplemented melatonin exhibited similar rescue effects in individual amino acids including valine, α-aminobutyric acid, aspartic acid, glutamic acid, α-aminoadipic, acid lysine, tyrosine, and cystine in these cows [ 104 ].…”

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

“…In these same cows, amino acids were evaluated by a transport system in which melatonin also rescued the effects of nutrient restriction in System A, System N, and Anion amino acids [ 104 ]. Furthermore, fall-supplemented melatonin exhibited similar rescue effects in individual amino acids including valine, α-aminobutyric acid, aspartic acid, glutamic acid, α-aminoadipic, acid lysine, tyrosine, and cystine in these cows [ 104 ]. Interestingly, in another replicate in which cows received melatonin in the summer, melatonin rescued the effects of nutrient restriction in System Br and System Bo amino acids [ 104 ].…”

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

“…Furthermore, fall-supplemented melatonin exhibited similar rescue effects in individual amino acids including valine, α-aminobutyric acid, aspartic acid, glutamic acid, α-aminoadipic, acid lysine, tyrosine, and cystine in these cows [ 104 ]. Interestingly, in another replicate in which cows received melatonin in the summer, melatonin rescued the effects of nutrient restriction in System Br and System Bo amino acids [ 104 ]. However, there were no effects of melatonin in total amino acids, essential amino acids, or individual amino acids in summer-supplemented cows [ 104 ].…”

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

“…Interestingly, in another replicate in which cows received melatonin in the summer, melatonin rescued the effects of nutrient restriction in System Br and System Bo amino acids [ 104 ]. However, there were no effects of melatonin in total amino acids, essential amino acids, or individual amino acids in summer-supplemented cows [ 104 ]. These data indicate that melatonin may be an effective therapeutic for nutrient stress during gestation when considering altered circulating amino acids.…”

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

See 4 more Smart Citations

Melatonin in Health and Disease: A Perspective for Livestock Production

et al. 2023

Self Cite

View full text Add to dashboard Cite

Mounting evidence in the literature indicates an important role of endogenous and exogenous melatonin in driving physiological and molecular adaptations in livestock. Melatonin has been extensively studied in seasonally polyestrous animals whereby supplementation studies have been used to adjust circannual rhythms in herds of animals under abnormal photoperiodic conditions. Livestock undergo multiple metabolic and physiological adaptation processes throughout their production cycle which can result in decreased immune response leading to chronic illness, weight loss, or decreased production efficiency; however, melatonin’s antioxidant capacity and immunostimulatory properties could alleviate these effects. The cardiovascular system responds to melatonin and depending on receptor type and localization, melatonin can vasodilate or vasoconstrict several systemic arteries, thereby controlling whole animal nutrient partitioning via vascular resistance. Increased incidences of non-communicable diseases in populations exposed to circadian disruption have uncovered novel pathways of neurohormones, such as melatonin, influence health, and disease. Perturbations in immune function can negatively impact the growth and development of livestock which has been examined following melatonin supplementation. Specifically, melatonin can influence nutrient uptake, circulating nutrient profiles, and endocrine profiles controlling economically important livestock growth and development. This review focuses on the physiological, cellular, and molecular implications of melatonin on the health and disease of domesticated food animals.

show abstract

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

Section: Amino Acids In Livestock Maternal Bloodmentioning

confidence: 99%

See 3 more Smart Citations

Melatonin in Health and Disease: A Perspective for Livestock Production

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Effects of late gestational nutrient restriction on uterine artery blood flow, placental size, and cotyledonary mRNA expression in primiparous beef females

Redifer,

Wichman,

Rathert-Williams

et al. 2024

Journal of Animal Science

View full text Add to dashboard Cite

Fall-calving primiparous beef females [body weight (BW): 451 ± 28 (SD) kg; body condition score (BCS): 5.4 ± 0.7] were individually-fed either 100% (control; CON; n = 13) or 70% (nutrient restricted; NR; n = 13) of metabolizable energy and metabolizable protein requirements for maintenance, pregnancy, and growth from day 160 of gestation to parturition. Doppler ultrasonography of both uterine arteries was conducted pre-treatment and every 21 d from days 181 to 265 of gestation. Expelled placentas were collected, and ipsilateral cotyledonary tissue was sampled to assess relative messenger ribonucleic acid (mRNA) expression. Placentas were separated into ipsilateral and contralateral sides, dissected (cotyledonary vs. intercotyledonary), and dried. Data were analyzed with nutritional plane, treatment initiation date, and calf sex (when P < 0.25) as fixed effects. Uterine blood flow included day and nutritional plane × day as repeated measures. We previously reported that post-calving, NR dams weighed 64 kg less and were 2.0 BCS lower than CON, but calf birth weight was not affected. Maternal heart rate was less (P < 0.001) for NR dams than CON after nutritional planes began. Nutritional plane did not affect (P ≥ 0.20) uterine artery hemodynamics, but all variables were affected (P ≤ 0.04) by day. Contralateral cotyledonary and placental weight were less (P ≤ 0.04) and contralateral intercotyledonary weight and number of cotyledons tended to be less (P ≤ 0.10) for NR dams than CON, but ipsilateral and whole placental weights were not affected (P ≥ 0.13). Ipsilateral placental weight as a percentage of total placental weight was greater (P = 0.03) for NR dams than CON. Whole placental cotyledonary:intercotyledonary weight was less (P = 0.01) for NR dams than CON. Placental efficiency was not affected (P = 0.89) by nutritional plane. Cotyledonary relative mRNA expression of GLUT3 and SNAT2 was greater (P ≤ 0.05) and relative expression of GLUT1, GLUT4, and NOS3 tended to be greater (P ≤ 0.07) for NR dams than CON. Nutritional plane did not affect (P ≥ 0.13) relative mRNA expression of GLUT5, 4F2hc, CAT1, LAT1, LAT2, VEGFA, FLT1, KDR, GUCY1B3, and PAG2. Despite less contralateral placental growth, beef heifers experiencing late gestational nutrient restriction maintained uterine artery blood flow and total placental mass and had 4 nutrient transporters and 1 angiogenic factor upregulated in cotyledons, all which likely contributed to conserving fetal growth.

show abstract

Differing planes of nutrition alter serum and histotroph amino acid composition in nonpregnant, multiparous beef cows on day 3 of the estrous cycle

Swanson,

Neville,

McCarthy

et al. 2024

Journal of Animal Science

View full text Add to dashboard Cite

Endometrial-derived uterine histotroph is a critical component of nutrient supply to a growing conceptus throughout gestation; however, the effect of nutritional plane on histotroph nutrient composition remains unknown in multiparous cows. We hypothesized that differing planes of nutrition would alter histotroph and serum nutrient composition in beef cattle. Thus, we evaluated serum and histotroph amino acid and glucose composition, and serum non-esterified fatty acids (NEFA) and blood urea nitrogen (BUN) in cows individually fed to maintain body weight (0 kd/d, n = 9; CON) compared with those losing moderate body weight (-0.7 kg/d, n = 9; NEG). After 49 d of differing nutritional planes, cows were subjected to the 7-d CoSynch + CIDR estrus synchronization protocol and then slaughtered on d 62. Blood serum (d 0 and 62) and uterine histotroph [d 62; from uterine horns ipsilateral and contralateral to the corpus luteum (CL)] were collected and analyzed for concentrations of amino acids, glucose, and NEFA. Performance characteristics, body composition via ultrasound (d 0 and 62), and carcass characteristics were collected. Body condition score, change in body weight, average daily gain (ADG), dry matter intake (DMI), and gain:feed (G:F) were decreased (P ≤ 0.05) in NEG vs. CON cows. There were no differences in body composition or carcass characteristics, except an increase (P ≤ 0.05) in dressing percentage in NEG cows due to differences in gut fill, consistent with study design. Serum NEFA increased (P ≤ 0.05) in the NEG group, but there were no differences between NEG vs. CON in glucose or BUN. Serum histidine increased (P ≤ 0.05) and alanine, isoleucine and tryptophan decreased (P ≤ 0.05) in NEG vs. CON cows. Compared with that of the uterine horn ipsilateral to the CL, histotroph from the uterine horn contralateral to the CL had increased (P ≤ 0.05) isoleucine, asparagine, and proline concentrations in NEG cows, and decreased (P ≤ 0.05) tryptophan as a proportion of essential and total amino acids. There were no differences in glucose concentrations of histotroph contralateral or ipsilateral to the CL. Cow nutritional plane does alter serum and histotroph amino acid composition, although the presence of an embryo may be necessary to fully elucidate these changes. Differences in serum and histotroph tryptophan should be given consideration in future studies due to its importance as an essential amino acid in protein synthesis and bioactive affects.

show abstract

Melatonin Supplementation Alters Maternal and Fetal Amino Acid Concentrations and Placental Nutrient Transporters in a Nutrient Restriction Bovine Model

Cited by 3 publications

References 30 publications

Melatonin in Health and Disease: A Perspective for Livestock Production

Melatonin in Health and Disease: A Perspective for Livestock Production

Effects of late gestational nutrient restriction on uterine artery blood flow, placental size, and cotyledonary mRNA expression in primiparous beef females

Differing planes of nutrition alter serum and histotroph amino acid composition in nonpregnant, multiparous beef cows on day 3 of the estrous cycle

Contact Info

Product

Resources

About