Melatonin secretion after surgery

Cronin, Arthur J.; Keifer, John C.; Davies, M.; King, Tonya S.; Bixler, Edward O.

doi:10.1016/s0140-6736(00)02795-1

Cited by 112 publications

(107 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17,[47][48][49][50] The fact that these actions require time to become effective after supple mentation could underlie our findings that mela tonin had no effect on the incidence of delirium but that it could affect duration after a critical period of 2 days. 51 The main strength of this study was our prag matic trial approach, with few exclusion criteria. Also, 60.4% of eligible patients consented to par ticipate, a higher percentage than in any compar able studies involving vulnerable elderly popula tions.…”

Section: Discussionmentioning

confidence: 99%

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Jonghe

Munster

Goslings

et al. 2014

CMAJ

144

139

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Jonghe

Munster

Goslings

et al. 2014

CMAJ

144

139

View full text Add to dashboard Cite

“…Previous studies demonstrated that delirium is thought to be caused primarily by inflammation and dopaminergic dysfunction [40,41]. Recent evidence suggests that delirium may cause acute brain damage associated with delirium in both the short-and long-term cognitive functioning [11,42]. Melatonin was regarded to reduce oxidative stress and preserve the fluidity of biological membranes, which might keep the brain away from the neurotoxic damage [43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

“…Observational studies have shown that delayed or low melatonin secretion is associated with delirium in intensive care unit in elderly patients [10][11][12][13]. Recent studies measured the postoperative plasma concentration of melatonin and the urinary excretion of 6-sulfatoxymelatonin (6-Sheng Chen and LiGen Shi contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials

et al. 2015

View full text Add to dashboard Cite

Recently, two high-quality clinical randomized controlled trials (RCTs) regarding the preventive effect of exogenous melatonin on delirium drew inconsistent conclusions. We therefore performed a systemic review to explore whether melatonin had a benefit on delirium prevention. MEDLINE, EMBASE, and Cochrane Library were searched from January 1980 to April 2015 for English language studies. After strict selection and evaluation, the data were extracted from the included four RCTs. The primary outcome of this meta-analysis was the incidence of delirium. The secondary outcome was the improvement of sleep-wake rhythm. A total of four RCTs with 669 elderly patients were included in the present study. Melatonin group showed a tendency to decrease the incidence of delirium (relative risk [RR] 0.41, 95 % confidence interval [CI] 0.15 to 1.13; P = 0.08) compared with control group. In subgroup analysis of the elderly patients in medical wards, melatonin supplementation decreased the incidence of delirium by 75 % (RR 0.25, 95 % CI 0.07 to 0.88; P = 0.03), but not in sleep-wake disturbance (RR 1.24, 95 % CI 0.51 to 3.00; P = 0.64). No differences were found in the incidence of delirium between the two groups in the elderly patients that were presented to surgical wards. In conclusion, melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients that were presented to medical wards. Further studies should provide sufficient evidence about the effect of melatonin on delirium in a large sample size.

show abstract

“…15 Postoperative patients demonstrate circadian rhythm disturbances not only in the sleep-wake cycle but also in other circadian rhythms, such as temperature, 16 and cortisol 17 and melatonin secretion. 18 The possible role opioids play in circadian pacemaker disturbance is undefined.…”

mentioning

confidence: 99%

Remifentanil Inhibits Rapid Eye Movement Sleep but Not the Nocturnal Melatonin Surge in Humans

Bonafide

Aucutt-Walter

DiVittore³

et al. 2008

Anesthesiology

View full text Add to dashboard Cite

Background: Postoperative patients are sleep deprived. Opioids, commonly administered for postoperative pain control, are often mistakenly considered inducers of naturally occurring sleep. This study describes the effect of the opioid remifentanil on nocturnal sleep in healthy volunteers. In addition, this study tests the hypothesis that opioid-induced sleep disturbance is caused by a circadian pacemaker disturbance, reflected by suppressed nocturnal plasma concentration of melatonin.Methods: Polysomnography was performed in 10 volunteers from 11:00 PM to 7:00 AM for four nights at 6-day intervals. On two nights, remifentanil (0.01-0.04 g ⅐ kg ؊1 ⅐ min ؊1 ) was

show abstract

Melatonin secretion after surgery

Cited by 112 publications

References 5 publications

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials

Remifentanil Inhibits Rapid Eye Movement Sleep but Not the Nocturnal Melatonin Surge in Humans

Contact Info

Product

Resources

About