Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function

Sharif, Rojin; Aghsami, Mehdi; Gharghabi, Mehdi; Sanati, Mehdi; Khorshidahmad, Tina; Vakilzadeh, Gelareh; Mehdizadeh, Hajar; Gholizadeh, Saber; Taghizadeh, Ghorban; Sharifzadeh, Mohammad

doi:10.1016/j.bbr.2016.08.040

Cited by 19 publications

(13 citation statements)

References 68 publications

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“…Melatonin is known as a scavenger of reactive oxygen and nitrogen species and an agent decreasing ROS generation as well as increasing the activity of antioxidant enzymes and glutathione content [ 8 ]. More and more studies have reported that MEL can improve memory impairment as a result of its antioxidant properties, which indicates that MEL may have a beneficial role in the treatment of neurodegenerative disorders involving enhanced OS [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment

Adamczyk-Sowa

Galiniak

Żyracka

et al. 2017

Oxidative Medicine and Cellular Longevity

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Multiple sclerosis (MS) is a disease involving oxidative stress (OS). This study was aimed at examination of the effect of melatonin supplementation on OS parameters, especially oxidative protein modifications of blood serum proteins, in MS patients. The study included 11 control subjects, 14 de novo diagnosed MS patients with the relapsing-remitting form of MS (RRMS), 36 patients with RRMS receiving interferon beta-1b (250 μg every other day), and 25 RRMS patients receiving interferon beta-1b plus melatonin (5 mg daily). The levels of N′-formylkynurenine, kynurenine, dityrosine, carbonyl groups, advanced glycation products (AGEs), advanced oxidation protein products (AOPP), and malondialdehyde were elevated in nontreated RRSM patients. N′-Formylkynurenine, kynurenine, AGEs, and carbonyl contents were decreased only in the group treated with interferon beta plus melatonin, while dityrosine and AOPP contents were decreased both in the group of patients treated with interferon beta and in the group treated with interferon beta-1b plus melatonin. These results demonstrate that melatonin ameliorates OS in MS patients supporting the view that combined administration of interferon beta-1b and melatonin can be more effective in reducing OS in MS patients than interferon beta-1b alone.

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Section: Introductionmentioning

confidence: 99%

Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment

Adamczyk-Sowa

Galiniak

Żyracka

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Toxic effects of Aβ in the brain may exert through an increase in neuroinflammation, mitochondrial dysfunction, and Reactive Oxygen Species (ROS), through which it induces oxidative stress in the brain [4,[6][7][8]. Oxidative stress plays a key role in learning and memory impairment [9]. Melatonin (MEL) (N-acetyl-5-methoxytryptamine) is a production of the pineal gland [10] and a multifunctional molecule that participate in a variety of physiological functions, including antioxidant [11][12][13][14] and radical scavenger against harmful effects of free radicals on biological membrane lipids, Deoxyribonucleic Acid (DNA), and proteins [12,15].…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin appears effective and safe in improving sleep quality in patients with AD [16]. There is growing evidence that sheds light on the protective role of MEL in memory deficit [9], aging, and Alzheimer disease [17]. MEL can be served as a neuroprotective hormone against mitochondrial damage [18], oxidative stress resulting in amelioration of learning deficits and neurodegenerative diseases [19,20].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Different Doses of Melatonin on Learning and Memory Deficit in Alzheimer Model of Rats

Keymoradzadeh

Komaki‬

Bakhshi

et al. 2021

Caspian J Neurol Sci

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Background: Alzheimer Disease (AD) is an age-related neurodegenerative disorder with a progressive impairment of cognitive function. The pineal gland hormone melatonin (MEL) has been known as a protection agent against AD. However, the effect of melatonin in various doses is inconsistent. Objectives: In this study, we aimed to investigate two doses of MEL on learning and memory in the amyloid-βeta (Aβ)-induced AD in the rats. Materials & Methods: Forty-eight male Wistar rats were used in the experiment and randomly divided control, sham, vehicle, AD, AD+MEL10 mg/kg, and AD+MEL 20 mg/kg groups. Intracerebroventricular injection of Aβ1–42 was used to develop the animal model of AD. Also, MEL-treated groups received an intraperitoneal injection of MEL for 4 next weeks. The Morris Water Maze (MWM) and Passive Avoidance Learning (PAL) tests were used to examine animals’ learning and memory. The brain of animals was removed for immunohistochemistry for anti- Amyloid Precursor Protein (APP). Results: Intra-peritoneal injection of MEL significantly improve learning and memory in MWM (P=0.000) and PAL test (P=0.000), but there were no significant changes in the two groups that received the melatonin (P>0.05). Histopathological analysis revealed that the clearance of APP deposition in the AD+MEL20 group was considerable compared with the AD+MEL10 group (P=0.000). Conclusion: Our findings indicate that 10 and 20 mg/kg doses of melatonin have similar results on learning and memory in the AD model. But 20 mg/kg of melatonin has significantly more effect on the clearance of APP deposition.

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“…Melatonin (N-Methyl-5-Methoxytryptamine) is a neurohormone that is synthesized in the pineal gland as well as in other organs of the body and their functions are crucial to vertebrate's life since they include the regulation of circadian rhythms by facilitating sleep and being a free radical scavenger in the brain. [1][2][3][4][5][6] Moreover, the intake of exogenous melatonin has been associated with more complex functions such as being effective in improving the conditions of animals in depression/anxiety models as well as in patients with mood disorders. [7][8][9][10] In addition to being effective in treating insomnia problems in older adults, 11 melatonin is also effective in improving cognitive functions such as memory.…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of exogenous melatonin versus transcranial magnetic stimulation on the quality of sleep, memory and mood of young adult people

Javier¹,

Arturo²,

Raquel³

et al. 2019

PPIJ

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Melatonin is a neurohormone that is secreted in the brain and which is associated with the sleep cycle, its clinical uses have been focused on sleep disorders, as well as on the improvement of cognitive performance and people's mood. Likewise, Transcranial Magnetic Stimulation (TMS) has been used in the same areas. The objective of this research was to analyze for two weeks, in young adults with an average age of 24 (the minimum age was 18 and the maximum was 32), which of the two treatments was more effective in inducing improvements in sleep quality, memory and mood. Four groups were formed, the placebo group (n=28), the sham group (n=28), the melatonin group (n=25) and the TMS group (n=16). All groups had a pre-test evaluation of sleep quality, memory, depression and anxiety. The experimental phase lasted 2 weeks and consisted of placebo exposure, sham stimulation, melatonin consumption (10 mg) and TMS (128 Hz). After this period, the post-test evaluation was carried out. The results showed that both treatments were equally effective in improving sleep quality, although TMS was more effective in improving memory and anxiety symptoms. It is inferred that both treatments are effective, although the question arises about their long-term use and the maintenance of the improvements.

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Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function

Cited by 19 publications

References 68 publications

Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment

Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment

The Effect of Different Doses of Melatonin on Learning and Memory Deficit in Alzheimer Model of Rats

The effectiveness of exogenous melatonin versus transcranial magnetic stimulation on the quality of sleep, memory and mood of young adult people

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