Melatonin‐Responsive Headache in Delayed Sleep Phase Syndrome: Preliminary Observations

Nagtegaal, J.E.; Smits, M.G.; Swart, A.C.W.; Kerkhof, G.A.; Meer, Y. G. Van Der

doi:10.1046/j.1526-4610.1998.3804303.x

Cited by 65 publications

(49 citation statements)

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“…The hypothalamus has exhibited specific activation during cluster headache attacks [42]. Melatonin is well established as a factor in circadian rhythmicity and might have therapeutic efficacy in cluster headache [43,44]. Further study of headache syndromes that exhibit chronobiologic patterns, such as cluster headache, has the most potential to provide a clearer understanding of the anatomic and physiologic links between headache and sleep.…”

Section: Mechanismsmentioning

confidence: 99%

Sleep and headaches

Rains

Poceta²,

Penzien³

2008

Curr Neurol Neurosci Rep

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Sleep has long been recognized to both provoke and relieve headache. Epidemiologic research has associated sleep disorders with more frequent and severe headaches. Chronic daily, awakening, and morning headache patterns are particularly suggestive of sleep disorders, including sleep-related breathing disorders, insomnia, circadian rhythm disorders, and parasomnias. Snoring and other indicators of sleep-disordered breathing are the most commonly studied and are particularly salient because of the potential for headache to improve or resolve with treatment of sleep. In addition to sleep disorders, clinical research correlates specific headache diagnoses (eg, migraine, tension-type, and cluster) with chronobiologic patterns and sleep processes, implicating common anatomic structures and neurochemical processes involved in the regulation of sleep and headache. Evidence strongly supports screening for sleep disorders by headache practitioners. Headache management should identify and treat sleep disorders that may improve or resolve headache.

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Section: Mechanismsmentioning

confidence: 99%

Sleep and headaches

Rains

Poceta²,

Penzien³

2008

Curr Neurol Neurosci Rep

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“…Cognitive effects were the most common adverse effects. A study by Leone et al [37] and some case reports and smaller series indicate that melatonin may have some effect in otherwise therapy refractory patients [48,54,56].…”

Section: Treatmentmentioning

confidence: 98%

Headaches with (ipsilateral) autonomic symptoms

May

2003

Journal of Neurology

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Primary short-lasting headaches broadly divide themselves into those associated with autonomic symptoms, so called trigemino-autonomic cephalgias (TACs), and those with little autonomic syndromes. The trigeminoautonomic cephalgias include cluster headache and paroxysmal hemicranias, in which head pain and cranial autonomic symptoms are prominent. The most striking feature of cluster headache is the circadian and circannual periodicity of the attacks. Inheritance may play a role in some families. The attacks are of extreme intensity, of short duration, occur unilaterally, and are accompanied by symptoms of autonomic dysfunction. Medical treatment includes both acute therapy aimed at aborting individual attacks and prophylactic therapy aimed at preventing recurrent attacks during the cluster period. Some types of trigemino-autonomic headaches, such as paroxysmal hemicrania and hemicrania continua have, unlike cluster headaches, a very robust response to indomethacin, leading to a consideration of indomethacin-sensitive headaches.

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“…In a study investigating the effects of melatonin in 30 patients with delayed sleep phase syndrome (DSPS) and their related headache disorders, attacks dramatically decreased after the initiation of melatonin treatment [Nagtegaal et al, 1998]. …”

Section: Melatonin Therapy In Headache Disordersmentioning

confidence: 99%

Melatonin therapy for headache disorders

Peres¹,

Masruha²,

Rapoport³

2007

Drug Development Research

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Even though efficacy is often the most important consideration for patient preference in migraine prevention, currently available medications do not meet patient expectation. Efficacy is in the range of 50% reduction in migraine attacks in 50% of patients studied for the best medications. Therefore, new options for migraine treatment are needed. Melatonin has been considered a good candidate for migraine and other headaches prevention due to its favorable mechanisms of action and excellent tolerability profile. In this article, we review the putative role of the pineal gland and melatonin in migraine pathophysiology and treatment. Drug Dev Res 68: 329-334, 2007. r 2007

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Melatonin‐Responsive Headache in Delayed Sleep Phase Syndrome: Preliminary Observations

Cited by 65 publications

References 0 publications

Sleep and headaches

Sleep and headaches

Headaches with (ipsilateral) autonomic symptoms

Melatonin therapy for headache disorders

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