Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons
Ming-Chun Hsieh,
Cheng-Yuan Lai,
Li-Ting Lin
et al.
Abstract:The neurohormone melatonin (MLT) demonstrates promising
potential
in ameliorating neuropathic pain induced by paclitaxel (PTX) chemotherapy.
However, little is known about its protective effect on dorsal root
ganglion (DRG) neurons in neuropathic pain resulting from the chemotherapeutic
drug PTX. Here, PTX-treated rats revealed that intrathecal administration
of MLT dose-dependently elevated hind paw withdrawal thresholds and
latency, indicating that MLT significantly reversed PTX-induced neuropathic
pain. Mec… Show more
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