Melatonin Regulates Type 2 Deiodinase Gene Expression in the Syrian Hamster

Revel, Florent G.; Saboureau, Michel; Pévet, Paul; Mikkelsen, Jens D.; Simonneaux, Valérie

doi:10.1210/en.2006-0606

Cited by 118 publications

(118 citation statements)

References 55 publications

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“…This was also found in CBA/N mice , Djungarian hamsters (Barrett et al, 2007;Watanabe et al, 2007b), and Japanese quail (Yasuo et al, 2005). Dio2 expression did not respond to photoperiodic changes in wild-type C3H, whereas it was strongly induced by long-day condition in CBA/N mice , Syrian hamsters (Revel et al, 2006;Yasuo et al, 2007), and Japanese quail (Yoshimura et al, 2003;Yasuo et al, 2005). In Djungarian hamsters, Dio2 expression was induced when animals were transferred from short to long days, but it did not change when animals were transferred from long to short days (Watanabe et al, 2004(Watanabe et al, , 2007bBarrett et al, 2007).…”

Section: Discussionmentioning

confidence: 55%

“…This molecular machinery is conserved in mammals. The expression of Dio2 and Dio3 is regulated by the photoperiod and melatonin in Syrian and Djungarian hamsters (Watanabe et al, 2004;Revel et al, 2006;Watanabe et al, 2007b;Yasuo et al, 2007), and TSHB is involved in the photoperiodic regulation of Dio2 in sheep (Hanon et al, 2008). Most interestingly, the expression of Dio2, Dio3, and TSHB is also under photoperiodic control in mice whose gonadal size is not affected by the photoperiod .…”

Section: Introductionmentioning

confidence: 97%

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Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor

Yasuo¹,

Yoshimura²,

Ebihara³

et al. 2009

J. Neurosci.

107

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Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and how targeted disruption of MT1, MT2, or both receptor types affects the expression level of two key genes for the photoperiodic gonadal regulation, type 2 and 3 deiodinase (Dio2 and Dio3, respectively). These are expressed in the ependymal cell layer lining the infundibular recess of the third ventricle and regulated by thyrotropin produced in the pars tuberalis. In wild-type C3H mice, Dio2 expression was constantly low, and no photoperiodic changes were observed, whereas Dio3 expression was upregulated under short-day conditions. In C3H with targeted disruption of MT1 and MT1/MT2, Dio2 expression was constitutively upregulated, Dio3 expression was constitutively downregulated, and the photoperiodic effect on Dio3 expression was abolished. Under short-day conditions, C3H with targeted disruption of MT2 displayed similar expression levels of Dio2 and Dio3 as wild-type animals, but they responded to long-day condition with a stronger suppression of Dio3 than wild-type mice. Melatonin injections into wild-type C57BL mice suppressed Dio2 expression and induced Dio3 expression under long-day conditions. These effects were abolished in C57BL mice with targeted disruption of MT1. All data suggest that the melatonin signal that transmits photoperiodic information to the hypothalamo-hypophysial axis acts on the MT1 receptor.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 97%

Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor

Yasuo¹,

Yoshimura²,

Ebihara³

et al. 2009

J. Neurosci.

107

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“…Further, T 3 administered exogenously under short-day conditions was observed to mimic the effects of long-day conditions on gonadal growth in hamsters (Barrett et al 2007, Freeman et al 2007). In addition, it has been reported that the expressions of DIO2 and DIO3 are regulated by melatonin in mammals (Watanabe et al 2004, Revel et al 2006, Barrett et al 2007, Yasuo et al 2007a. It is also noteworthy that in goats, which breed under short-day conditions, a long-day stimulus suppressed the expression of DIO2; this effect was contrary to that observed in species that breed under longday conditions ).…”

Section: Extension Of Findings To Photoperiodic Mammalsmentioning

confidence: 92%

“…Although some interspecies differences exist with regard to the relative importance of DIO2 and DIO3 in photoperiodism, the photoperiodic regulation of DIO2 and/or DIO3 expression has been confirmed in various mammalian species, including the Djungarian (Siberian) hamster (Watanabe et al 2004, Barrett et al 2007, Freeman et al 2007), Syrian hamster (Revel et al 2006, Yasuo et al 2007a, rat (Yasuo et al 2007b), and goat . Further, T 3 administered exogenously under short-day conditions was observed to mimic the effects of long-day conditions on gonadal growth in hamsters (Barrett et al 2007, Freeman et al 2007).…”

Section: Extension Of Findings To Photoperiodic Mammalsmentioning

confidence: 99%

Thyroid hormones and seasonal reproductive neuroendocrine interactions

Nakao¹,

Ono²,

Yoshimura³

2008

Reproduction

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Many animals that breed seasonally measure the day length (photoperiod) and use these measurements as predictive information to prepare themselves for annual breeding. For several decades, thyroid hormones have been known to be involved in this biological process; however, their precise roles remain unknown. Recent molecular analyses have revealed that local thyroid hormone activation in the hypothalamus plays a critical role in the regulation of the neuroendocrine axis involved in seasonal reproduction in both birds and mammals. Furthermore, functional genomics analyses have revealed a novel function of the hormone thyrotropin. This hormone plays a key role in signaling day-length changes to the brain and thus triggers seasonal breeding. This review aims to summarize the currently available knowledge on the interactions between elements of the thyroid hormone axis and the neuroendocrine system involved in seasonal reproduction.

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“…Thyroid hormones (Vriend 1985;Dawson 1998;Wilson & Reinert 2000;Watanabe et al 2004;Revel et al 2006b;Freeman et al 2007) and the MBH/ premammillary bodies Malpaux et al 1998;Lewis et al 2002) have also been implicated in the transduction of day length information in several other birds and mammals, and melatonin has been shown to regulate MBH type 2 iodothyronine deiodinase expression in several rodents (Watanabe et al 2004;Revel et al 2006b;Yasuo et al 2007). Thus, a role for thyroid hormones within the MBH may be an evolutionarily conserved photoperiodic mechanism in birds and mammals, directly regulated by light impinging on deep brain and possibly retinal photoreceptors in the former and indirectly by light affecting the duration of nocturnal melatonin secretion in the latter.…”

Section: Photoperiodic Time Measurement (A) Modelsmentioning

confidence: 99%

Tracking the seasons: the internal calendars of vertebrates

Paul

Zucker

Schwartz

2007

Phil. Trans. R. Soc. B

169

151

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Animals have evolved many season-specific behavioural and physiological adaptations that allow them to both cope with and exploit the cyclic annual environment. Two classes of endogenous annual timekeeping mechanisms enable animals to track, anticipate and prepare for the seasons: a timer that measures an interval of several months and a clock that oscillates with a period of approximately a year. Here, we discuss the basic properties and biological substrates of these timekeeping mechanisms, as well as their reliance on, and encoding of environmental cues to accurately time seasonal events. While the separate classification of interval timers and circannual clocks has elucidated important differences in their underlying properties, comparative physiological investigations, especially those regarding seasonal prolactin secretions, hint at the possibility of common substrates.Keywords: seasonality; photoperiodism; circannual; interval timers While the Earth remaineth, seedtime and harvest, and cold and heat, and summer and winter, and day and night shall not cease.Genesis 8: 22, King James Version (1611) As the Earth makes its yearly orbit around the Sun, the planet's 23.58 axial tilt leads to the cyclical environmental changes that we call the seasons. Recurrent challenges to the survival of organisms and their offspring arise with the dawning of each new season, and animals have evolved seasonally induced changes in phenotype that adapt them to these predictable events. For example, in many temperate environments, winter is generally characterized by severe decreases in ambient temperature and food availability, leading to increased energetic demands at a time when resources are diminished. Because energy requirements of female mammals typically increase markedly during lactation (Bronson 1989) and newly weaned offspring are particularly vulnerable to environmental perturbations (Hill 1992), raising offspring during this time of year is often futile. Thus, many temperate species have evolved winter-specific behaviours and physiology to conserve energy (e.g. hibernation, a more insulative pelage, huddling) or provide for escape (e.g. migration). Many species also increase the chances of offspring survival by timing their mating behaviours so that parturition occurs during energetically favourable times of year.

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Melatonin Regulates Type 2 Deiodinase Gene Expression in the Syrian Hamster

Cited by 118 publications

References 55 publications

Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor

Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor

Thyroid hormones and seasonal reproductive neuroendocrine interactions

Tracking the seasons: the internal calendars of vertebrates

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