Melatonin regulates tumor aggressiveness under acidosis condition in breast cancer cell lines

Sonehara, Nathália Martins; Lacerda, Jéssica Zani; Jardim‐Perassi, Bruna V.; Paula, Rubens; Moschetta-Pinheiro, Marina Gobbe; Souza, Ynaiá Santos Traba; Andrade, Júlia Carolina Junqueira de; Zuccari, Débora Aparecida Pires de Campos

doi:10.3892/ol.2018.9758

Cited by 28 publications

(29 citation statements)

References 50 publications

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“…Melatonin was able to decrease GLUT1 protein expression levels in both cell lines, both at normal (7.2) and acidic pH (6.7). It was concluded that melatonin treatment increases apoptosis and decreases proliferation and GLUT1 protein expression under acute acidosis conditions in breast cancer cell lines [108] (Table 2).…”

Section: Melatoninmentioning

confidence: 99%

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

Barbosa

Martel

2020

Cancers

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Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in much higher rates of glucose uptake and glycolytic oxidation coupled with the production of lactic acid, even in the presence of oxygen. Consequently, cancer cells have higher glucose needs and thus display a higher sensitivity to glucose deprivation-induced death than normal cells. So, inhibitors of glucose uptake are potential therapeutic targets in cancer. Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer death in women worldwide. Overexpression of facilitative glucose transporters (GLUT), mainly GLUT1, in breast cancer cells is firmly established, and the consequences of GLUT inhibition and/or knockout are under investigation. Herein we review the compounds, both of natural and synthetic origin, found to interfere with uptake of glucose by breast cancer cells, and the consequences of interference with that mechanism on breast cancer cell biology. We will also present data where the interaction with GLUT is exploited in order to increase the efficiency or selectivity of anticancer agents, in breast cancer cells.

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Section: Melatoninmentioning

confidence: 99%

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

Barbosa

Martel

2020

Cancers

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“…Melatonin (MT) has been postulated to be an antiestrogenic agent, so it should be strongly considered, at least in the treatment of the same cohorts of BC patients that can benefit from antiestrogens [ 280 , 281 ]. In BC cell lines, treatment with MT decreases tumor aggressiveness and increases apoptosis [ 282 ]. MT plays a number of other different actions as an anti-cancer agent [ 283 ].…”

Section: Other Ph-related Available Therapies In Breast Cancer Trementioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

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A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.

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“…Cell viability was evaluated under acidosis conditions by MTT assay, using 4-morpholine-ethanesulfonic acid to produce a pH value of 6.7 24,25 . Cells were treated with selected chalcones 11 and 17 at their respective IC 50 values.…”

Section: Antiproliferative Activity Of Selected Chalcones 11 and 17 Umentioning

confidence: 99%

Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

Santos

Anselmo

Oliveira

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

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Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC) cells (MDA-MB-231 line). Antiproliferative screening by MTT assay resulted in two most active compounds: 2-fluoro-4'-aminochalcone (11) and 3-pyridyl-4'-aminochalcone (17). Their IC 50 values ranged from 13.2 to 34.7 mM against both cell lines. Selected chalcones are weak basic compounds and maintained their antiproliferative activity under acidosis conditions (pH 6.7), indicating their resistance to ion-trapping effect. The mode of breast cancer cells death was investigated and chalcones 11 and 17 were able to induce apoptosis rather than necrosis in both lines. Antiproliferative target investigations with MCF-7 cells suggested 11 and 17 upregulated p53 protein expression and did not affect Sp1 protein expression. Future studies on chalcones 11 and 17 can define their in vivo therapeutic potential.

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Melatonin regulates tumor aggressiveness under acidosis condition in breast cancer cell lines

Cited by 28 publications

References 50 publications

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

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