Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats

Baydaş, Gıyasettin; Reíter, Russel J.; Yasar, Abdullah; Tuzcu, Mehmet; Akdemir, Ismail; Недзвецкий, В. С.

doi:10.1016/s0891-5849(03)00408-8

Cited by 116 publications

(77 citation statements)

References 49 publications

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“…Our result is similar to previous studies Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b). Revsin et al study showed that one month after STZ treatment, the number of astrocytes significantly increased in the STZtreated group as compared to the vehicle treated group.…”

Section: Discussionsupporting

confidence: 93%

“…The alterations of astrocytes number are possibly due to oxidative stress (Baydas et al, 2003b) and free radical formation (Baydas et al, 2003a). Also Baydas study showed that the gliosis that occurs in diabetes mellitus is mediated, at least indirectly, by free radical formation and antioxidants (Baydas et al, 2003a).…”

Section: Discussionmentioning

confidence: 97%

“…Several studies showed that astrocytes of hippocampus of diabetic rats can change due to melatonin and vitamin E (Baydas et al, 2003a;Baydas et al, 2003b).…”

Section: Discussionmentioning

confidence: 99%

“…Some researches have indicated that diabetes led to astroglial alterations as increasing of number of astrocytes Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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GOLALIPOUR, M. J.; GHAFARI, S.; LATIFIMOGHADAM, M. H. & KABOLI, S.Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica. Int. J. Morphol., 29(4):1307-1312, 2011. SUMMARY:Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

“…Several studies showed that astrocytes of hippocampus of diabetic rats can change due to melatonin and vitamin E (Baydas et al, 2003a;Baydas et al, 2003b).…”

Section: Discussionmentioning

confidence: 99%

“…Some researches have indicated that diabetes led to astroglial alterations as increasing of number of astrocytes Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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“…The potential reason of the increase in lipid peroxidation in STZ induced DM group may be the decrease of GSH levels. In accordance with the previous studies (Tachi et al 2001;Dincer et al 2002), Baydas et al (Baydas et al 2003) have reported that untreated diabetes generally causes lower GSH levels in different areas of the brain. Moreover, we also represented in the present study that GSH levels in the crocin treated diabetes group were significantly higher than the untreated diabetes group.…”

Section: Discussionsupporting

confidence: 91%

Neuro-protective effects of Crocin on brain and cerebellum tissues in diabetic rats

Altinzo¹,

Oner²,

Elbe³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Increase in free oxygen radicals and the disruption of defense system make the neurons and astrocytes more sensitive against oxidative damage. Materials and Methods: Rats were divided into three groups containing 10, rats in each group namely: control (C) group, Diabetes Mellitus (DM) group, and Diabetes Mellitus + crocin (DM+crocin) group. Tissue samples were processed by routine histological and biochemical procedures. The sections were stained with Hematoxylen-eosin. Malondialdehyde (MDA), glutathione (GSH), blood glucose, HbA1c levels and xanthine oxidase (XO) activities were assayed. Results: The histological appearence of the cerebrum and cerebellum were normal in the control group. DM group showed some histopathological changes including congestion, perivascular and perineuronal edema in cerebrum. In DM + crocin group, histopathological changes in cerebrum and cerebellum markedly reduced. MDA level and XO activities increased significantly in DM group (P<0.01), but decreased significantly in DM + crocin group when compared to DM group (P<0.01). Blood glucose concentrations increased significantly (p<0.01) in DM group), but decreased significantly in DM + crocin group when compared with DM group (p<0.05). Blood HbA1c levels were normal in control group. But there were significant differences between control and DM groups (p<0.01). On the other hand, blood HbA1c levels decreased in DM+crocin group when compared with the DM group, but it was not statistically significant (p > 0.05). Conclusion: Due to the fact that crocin has an antioxidant and anti-hyperglycemic effects, it can protect the brain and cerebellum tissue against the complications of oxidative stress.

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Alteration of Glial Fibrillary Acidic Proteins Immunoreactivity in Astrocytes of the Spinal Cord Diabetic Rats

Afsari

Renno

Abd-El-Basset

2008

The Anatomical Record

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Diabetes affects retinal and nervous glial cells, especially the astrocytes. A key indicator of this response is the alteration in the level of intermediate filament glial fibrillary acidic protein (GFAP) and number of GFAP-immunoreactive astrocytes. To date, no study has investigated the effect of diabetes on the distribution of GFAP-immunoreactive astrocytes in the spinal cord. Therefore, the present study investigated the effect of diabetes on the number of GFAP-immunoreactive astrocytes in the gray matter of the spinal cord of streptozotocin-induced diabetic Wistar rats. Animals were divided into six groups (n 5 7); 6 weeks and 12 weeks diabetic duration groups and their respective age-matched normal control and sham control groups. Our results demonstrated a significant (P < 0.001) decrease in the number of GFAP-immunoreactive astrocytes in different areas of the spinal cord sections of the 6 weeks and 12 weeks long diabetic rats when compared with the spinal cord of normal and sham control groups of comparable age. The mean percentage in total number of GFAP-immunoreactive astrocytes in the whole gray matter areas of the spinal cord of the 6 and 12 weeks diabetic groups were approximately 28% and 41% less than control groups. Furthermore, the 12 weeks diabetic group showed a significant (P < 0.001) reduction in the number of GFAP-immunoreactive astrocytes when compared with the 6 weeks diabetic animals. These results suggest that the induction of diabetes is associated with a reduction in GFAP-positive astrocytes in the spinal cord, which may affect the functional support and role of astrocytic cells in the nervous tissue. This in turn may contribute to the pathological changes associated with diabetic state in the central nervous system. Anat

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Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats

Cited by 116 publications

References 49 publications

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Neuro-protective effects of Crocin on brain and cerebellum tissues in diabetic rats

Alteration of Glial Fibrillary Acidic Proteins Immunoreactivity in Astrocytes of the Spinal Cord Diabetic Rats

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