Melatonin reduces cadmium accumulation via mediating the nitric oxide accumulation and increasing the cell wall fixation capacity of cadmium in rice

Huang, Jing; Jing, Huai Kang; Zhang, Yue; Chen, Si Yuan; Wang, Hao Yu; Cao, Yuan; Zhang, Zheng; Lu, Yun; Zheng, Qing Song; Shen, Ren Fang; Zhu, Xiao Fang

doi:10.1016/j.jhazmat.2022.130529

Cited by 24 publications

(5 citation statements)

References 75 publications

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“…The use of phytohormones to increase plant resistance against HMs stress is an effective method that causes no environmental pollution Haider et al 40 Melatonin as a powerful biostimulant and antioxidant is considered as a natural treatment to manage HMs stress in plants. 15 , 16 , 41 , 42 Parallelly, the use of signaling molecules such as H 2 S, is also recognized as a powerful mitigator strategy against HMs stress in plants. During the current investigation, stock plants exposed to Cd stress had lower biomass, which was associated with Cd accumulation, which resulted in chlorophyll degradation.…”

Section: Discussionmentioning

confidence: 99%

Synergistic interplay between melatonin and hydrogen sulfide enhances cadmium-induced oxidative stress resistance in stock ( Matthiola incana L.)

Zulfiqar,

Moosa,

Ali

et al. 2024

Plant Signaling & Behavior

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Ornamental crops particularly cut flowers are considered sensitive to heavy metals (HMs) induced oxidative stress condition. Melatonin (MLT) is a versatile phytohormone with the ability to mitigate abiotic stresses induced oxidative stress in plants. Similarly, signaling molecules such as hydrogen sulfide (H 2 S) have emerged as potential options for resolving HMs related problems in plants. The mechanisms underlying the combined application of MLT and H 2 S are not yet explored. Therefore, we evaluated the ability of individual and combined applications of MLT (100 μM) and H 2 S in the form of sodium hydrosulfide (NaHS), a donor of H 2 S, (1.5 mM) to alleviate cadmium (Cd) stress (50 mg L −1 ) in stock ( Matthiola incana L.) plants by measuring various morpho-physiological and biochemical characteristics. The results depicted that Cd-stress inhibited growth, photosynthesis and induced Cd-associated oxidative stress as depicted by excessive ROS accumulation. Combined application of MLT and H 2 S efficiently recovered all these attributes. Furthermore, Cd stress-induced oxidative stress markers including electrolyte leakage, malondialdehyde, and hydrogen peroxide are partially reversed in Cd-stressed plants by MLT and H 2 S application. This might be attributed to MLT or H 2 S induced antioxidant plant defense activities, which effectively reduce the severity of oxidative stress indicators. Overall, MLT and H 2 S supplementation, favorably regulated Cd tolerance in stock; yet, the combined use had a greater effect on Cd tolerance than the independent application.

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Section: Discussionmentioning

confidence: 99%

Synergistic interplay between melatonin and hydrogen sulfide enhances cadmium-induced oxidative stress resistance in stock ( Matthiola incana L.)

Zulfiqar,

Moosa,

Ali

et al. 2024

Plant Signaling & Behavior

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“…Its overexpression and downregulation were closely coupled with melatonin synthesis and the Cd stress response, with the latter involving the upregulated expression of the BiP4 chaperone gene. Thus, it is tempting to speculate that melatonin-based Cd tolerance is one of many defense mechanisms by which rice and possibly other plants cope with Cd stress, with the induction of Cd intake-related genes [50], ROS detoxification genes [7,58], phytochelatin synthesis genes [53], and HSPs [8,27] among the others. Our findings open a new window to crop improvement in areas with a high soil Cd content, by way of either classical breeding or genetic engineering strategies that increase melatonin synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin thus orchestrates the response to both biotic and abiotic stresses, including Cd stress in plants [ 25 , 27 , 49 ]. For instance, in rice seedlings treated with 1 µM melatonin in a hydroponic nutrient solution, Cd accumulation is efficiently alleviated by a mechanism involving enhanced hemicellulose levels in conjunction with decreased levels of transporter genes, thus lowering Cd intake [ 50 ]. In pepper seedlings, treatment with 5 µM melatonin enhances Cd stress tolerance by lowering leaf/root Cd concentrations and ROS contents while upregulating antioxidant genes encoding SOD and APX [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Rice is a major dietary crop capable of high levels of Cd adsorption [ 50 ], which together with its relatively high levels of melatonin production makes it well suited for the study of melatonin biosynthesis and Cd tolerance in plants [ 20 ]. Previous studies have shown that melatonin production is dramatically induced in Cd-treated rice plants [ 20 , 27 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

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Melatonin-Regulated Chaperone Binding Protein Plays a Key Role in Cadmium Stress Tolerance in Rice, Revealed by the Functional Characterization of a Novel Serotonin N-Acetyltransferase 3 (SNAT3) in Rice

Lee,

Back

2024

IJMS

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The study of the mechanisms by which melatonin protects against cadmium (Cd) toxicity in plants is still in its infancy, particularly at the molecular level. In this study, the gene encoding a novel serotonin N-acetyltransferase 3 (SNAT3) in rice, a pivotal enzyme in the melatonin biosynthetic pathway, was cloned. Rice (Oryza sativa) OsSNAT3 is the first identified plant ortholog of archaeon Thermoplasma volcanium SNAT. The purified recombinant OsSNAT3 catalyzed the conversion of serotonin and 5-methoxytryptamine to N-acetylserotonin and melatonin, respectively. The suppression of OsSNAT3 by RNAi led to a decline in endogenous melatonin levels followed by a reduction in Cd tolerance in transgenic RNAi rice lines. In addition, the expression levels of genes encoding the endoplasmic reticulum (ER) chaperones BiP3, BiP4, and BiP5 were much lower in RNAi lines than in the wild type. In transgenic rice plants overexpressing OsSNAT3 (SNAT3-OE), however, melatonin levels were higher than in wild-type plants. SNAT3-OE plants also tolerated Cd stress, as indicated by seedling growth, malondialdehyde, and chlorophyll levels. BiP4 expression was much higher in the SNAT3-OE lines than in the wild type. These results indicate that melatonin engineering could help crops withstand Cd stress, resulting in high yields in Cd-contaminated fields.

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“…Of note, in addition to the exogenous substances mentioned above, the addition of melatonin, citric acid, and amino acids can also lead to higher Cd tolerance in plants [ 245 , 246 , 247 ]. Therefore, exploring more beneficial exogenous substances, forms, and proportions of additions are of practical significance to improve the efficiency of phytoremediation.…”

Section: Effect Of Exogenous Substances On Phytoremediation Of Soil C...mentioning

confidence: 99%

The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects

Zhang,

Yang,

Yang

et al. 2024

Cells

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Cadmium (Cd) exerts a toxic influence on numerous crucial growth and development processes in plants, notably affecting seed germination rate, transpiration rate, chlorophyll content, and biomass. While considerable advances in Cd uptake and detoxification of plants have been made, the mechanisms by which plants adapt to and tolerate Cd toxicity remain elusive. This review focuses on the relationship between Cd and plants and the prospects for phytoremediation of Cd pollution. We highlight the following issues: (1) the present state of Cd pollution and its associated hazards, encompassing the sources and distribution of Cd and the risks posed to human health; (2) the mechanisms underlying the uptake and transport of Cd, including the physiological processes associated with the uptake, translocation, and detoxification of Cd, as well as the pertinent gene families implicated in these processes; (3) the detrimental effects of Cd on plants and the mechanisms of detoxification, such as the activation of resistance genes, root chelation, vacuolar compartmentalization, the activation of antioxidant systems and the generation of non-enzymatic antioxidants; (4) the practical application of phytoremediation and the impact of incorporating exogenous substances on the Cd tolerance of plants.

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Melatonin reduces cadmium accumulation via mediating the nitric oxide accumulation and increasing the cell wall fixation capacity of cadmium in rice

Cited by 24 publications

References 75 publications

Synergistic interplay between melatonin and hydrogen sulfide enhances cadmium-induced oxidative stress resistance in stock ( Matthiola incana L.)

Synergistic interplay between melatonin and hydrogen sulfide enhances cadmium-induced oxidative stress resistance in stock ( Matthiola incana L.)

Melatonin-Regulated Chaperone Binding Protein Plays a Key Role in Cadmium Stress Tolerance in Rice, Revealed by the Functional Characterization of a Novel Serotonin N-Acetyltransferase 3 (SNAT3) in Rice

The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects

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