Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis

Moradi, Mojtaba; Goodarzi, Nader; Faramarzi, Azita; Cheraghi, Hadi; Hashemian, Amir Hossein; Jalili, Cyrus

doi:10.1016/j.biopha.2021.111481

Cited by 42 publications

(49 citation statements)

References 85 publications

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“…Chemotherapeutic agents induce inflammatory, and apoptosis and oxidative stress by inducing an increase in ROS in normal cells (Moradi et al, 2021; Nna et al, 2020). It was reported that CP application induced apoptosis by increasing caspase‐3 expression in testis, but melatonin treatment prevented apoptosis by decreasing caspase‐3 expression.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to our study, Rezaei et al (2021) reported that SA inhibits cyclophosphamide‐induced testicular apoptosis. Additionally, Moradi et al (2021) reported that CP administration caused downregulation of Bcl‐2 in testis cells, but melatonin treatment caused upregulation of Bcl‐2 in testis cells. Similarly, in our study, CP treatment decreased Bcl‐2 expression in testicular cells, but SA treatment showed an antiapoptotic effect by increasing Bcl‐2 expression.…”

Section: Discussionmentioning

confidence: 99%

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Sinapic acid ameliorates cisplatin‐induced disruptions in testicular steroidogenesis and spermatogenesis by modulating androgen receptor, proliferating cell nuclear antigen and apoptosis in male rats

Demir

Altındağ

2022

Andrologia

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The chemotherapeutic cisplatin, which is widely used in many cancer types, causes testicular toxicity. Sinapic acid has many therapeutic effects such as antioxidant, anti‐inflammatory and antihyperglycaemic. This study aimed to investigate the improving effects of sinapic acid in cisplatin‐induced testicular toxicity. Twenty‐eight rats were distributed into 4 groups. Control group: saline was applied intraperitoneal. Cisplatin group: A single dose of 7 mg/kg of cisplatin was injected into rats. Cisplatin +Sinapic acid group: 3 days after a single dose of 7 mg/kg cisplatin was injected, 25 mg/kg of sinapic acid was given for 7 days. Sinapic acid group: rats were received 25 mg/kg/day of sinapic acid. Numerical density of spermatogonium, Leydig and volume density of germinal epithelial were calculated. Caspase‐3, Bcl‐2, AR and PCNA expressions in testis were evaluated and testosterone and LH levels were measured. Cisplatin application decreased the numerical density of spermatogonium and Leydig, volume density of germinal, epididymal sperm count, testosterone, LH and the expressions of Bcl‐2, AR and PCNA in testis. However, sinapic acid treatment significantly restored the parameters of our study. The results of the present study revealed that cisplatin can cause male reproductive toxicity and sinapic acid can have improving effects against cisplatin‐induced male reproductive toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sinapic acid ameliorates cisplatin‐induced disruptions in testicular steroidogenesis and spermatogenesis by modulating androgen receptor, proliferating cell nuclear antigen and apoptosis in male rats

Demir

Altındağ

2022

Andrologia

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“…. Furthermore, melatonin can protect the testes against CP toxicity via reducing the apoptosis and oxidative stress induced by CP(Moradi et al, 2021). In addition, melatonin is effective in ameliorating CP-mediated nephrotoxicity via reducing TNF-α, IL-6 L IL-1β, and transforming growth factor-beta (TGF-β) (Al Za'abi,Ali, Al Sabahi, & Ali, 2021).…”

mentioning

confidence: 99%

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Abadi

Mirzaei

Mahabady

et al. 2021

Phytotherapy Research

103

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“…Herein, CIS injection depressed SOD, CAT and GPx activities, while the MDA level increased notably in the testes, kidney and liver. CIS generates ROS capable of deactivating SOD and CAT and increases the cellular utilization of GSH, leading to reduced cellular antioxidant enzyme activities and glutathione homeostasis [41]. The resultant oxidative milieu attacks lipid-laden bio-membranes to initiate lipid peroxidation, hence the increased level of MDA in our study.…”

Section: Discussionmentioning

confidence: 68%

Tiliacora triandra attenuates cisplatin triggered hepatorenal and testicular toxicity in rats by modulating oxidative inflammation, apoptosis and endocrine deficit

Zhang¹,

Peng²,

Wang³

et al. 2022

Front. Biosci. (Landmark Ed)

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Purpose: Cisplatin (CIS) is a platinum based anticancer drug that has demonstrated significant efficacy against various types of cancers. Unfortunately, this drug is also famous for its severe side effects on delicate organs. Herein this study examined the hepatorenal and testicular protective effects of TiTE against CIS-induced hepatorenal and testicular insults. Methods: Rats were administered with TiTE (250 and 500 mg/kg body weight) for 4 weeks, while a single dose of CIS (2.5 mg/kg body weight) was injected once per week from week 2 to week 4. Results: Treatment with TITE significantly attenuated CIS-induced increases in serum creatinine, blood urea nitrogen (BUN), uric acid, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, TiTE treatment also decreased oxidative stress (MDA) inflammations (TNF-α, IL-1β, IL-6, NF-κB) and apoptosis (caspase-3 activity) and restored hepatorenal and testicular antioxidant defense (SOD, CAT and GPx) in CIS treated rats. Additionally, the TiTE improved sperm count, motility and viability, and ameliorated the reduced serum levels of testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in CIS-injected rats. TiTE also curtailed hepatorenal and testicular histological changes in CIS treated rats. Conclusion: The findings from the study indicated that TiTE displayed hepatorenal and testicular protective effects via inhibition of oxidative stress-mediated inflammation and endocrine imbalance in rats.

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Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis

Cited by 42 publications

References 85 publications

Sinapic acid ameliorates cisplatin‐induced disruptions in testicular steroidogenesis and spermatogenesis by modulating androgen receptor, proliferating cell nuclear antigen and apoptosis in male rats

Sinapic acid ameliorates cisplatin‐induced disruptions in testicular steroidogenesis and spermatogenesis by modulating androgen receptor, proliferating cell nuclear antigen and apoptosis in male rats

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Tiliacora triandra attenuates cisplatin triggered hepatorenal and testicular toxicity in rats by modulating oxidative inflammation, apoptosis and endocrine deficit

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