Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency

Hermoso, Danielle Aparecida Munhos; Campos-Shimada, Lilian Brites; Gilglioni, Eduardo Hideo; Constantin, Jorgete; Mito, Márcio Shigueaki; Hermoso, Aparecida Pinto Munhos; Salgueiro-Pagadigorria, Clairce Luzia; Ishii–Iwamoto, Emy Luiza

doi:10.1016/j.lfs.2016.05.044

Cited by 24 publications

(15 citation statements)

References 56 publications

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“…Chronic (4 months) or short-term (3 weeks) treatment with melatonin in obese rats was shown to prevent metabolic abnormalities and protect against cardiac ischaemia-reperfusion injury (36,76) . Similarly, non-alcoholic fatty liver disease and associated oxidative injury of the liver were attenuated by melatonin treatment (39,42) . Our data also revealed that melatonin prevented intra-abdominal obesity and reduced intestinal inflammation in HFD-fed rats.…”

Section: Discussionmentioning

confidence: 97%

“…Long-term treatment with melatonin reduced body weight and intra-abdominal adiposity and prevented metabolic abnormalities induced by high-energy diet or ageing (36,37) . Similarly, a prolonged treatment with melatonin diminished oxidative stress and hepatic inflammation and improved hepatic functions in patients or rats with non-alcoholic fatty liver disease (38)(39)(40) , possibly by its radical scavenging and antioxidant activities (41,42) . Recently, it was shown that melatonin treatment in HFD-fed mice reduced body weight, protected against hepatic steatosis, improved insulin resistance and reversed dysbiosis by decreasing the ratio of Firmicutes to Bacteroidetes (43) .…”

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confidence: 99%

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The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats

et al. 2019

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High-fat diet (HFD) consumption leads to metabolic disorders, gastrointestinal dysfunction and intestinal dysbiosis. Antibiotics also disrupt the composition of intestinal microbiota. The aim of the present study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of antibiotics and/or melatonin treatments on diet-induced hepato-intestinal dysfunction and inflammation. Male Sprague–Dawley rats were pair-fed with either standard chow or HFD (45 % fat) and were given tap water or melatonin (4 mg/kg per d) or melatonin plus antibiotics (ABX; neomycin, ampicillin, metronidazole; each 1 g/l) in drinking water for 2 weeks. On the 14th day, colonic motility was measured and the next day intestinal transit was assessed using charcoal propagation. Trunk blood, liver and intestine samples were removed for biochemical and histopathological evaluations, and faeces were collected for microbiota analysis. A 2-week HFD feeding increased blood glucose level and perirenal fat weight, induced low-level hepatic and intestinal inflammation, delayed intestinal transit, led to deterioration of epithelial tight junctions and overgrowth of colonic bacteria. Melatonin intake in HFD-fed rats reduced ileal inflammation, colonic motility and perirenal fat accumulation. ABX abolished increases in fat accumulation and blood glucose, reduced ileal oxidative damage, suppressed HFD-induced overgrowth in colonic bacteria, and reversed HFD-induced delay in intestinal transit; however, hepatic neutrophil accumulation, hepatic injury and dysfunction were further enhanced. In conclusion, the results demonstrate that even a short-term HFD ingestion results in hepato-intestinal inflammatory state and alterations in bacterial populations, which may be worsened with antibiotic intake, but alleviated by melatonin.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats

et al. 2019

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“…In ovariectomized (OVX) rats, lipid accumulation and cellular oxidative stress were prevented by exogenous melatonin treatment in the liver. Melatonin alleviated steatosis and cellular oxidative stress in the livers of OVX rats [115]. Moreover, microRNAs (miRNAs) are pivotal regulators of gene regulation and their dysfunctions are common features in various metabolic diseases.…”

Section: Protective Effects Of Melatonin On Hepatic Steatosismentioning

confidence: 99%

Effects of Melatonin on Liver Injuries and Diseases

Zhang

Meng

et al. 2017

IJMS

101

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Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

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“…Studi membuktikan bahwa tikus yang di ovariektomi menunjukkan beberapa gejala dari sindrom metabolik, seperti peningkatan berat badan, adipositas terkait dengan akumulasi lipid hati (steatosis) dan stres oksidatif. 8 Berdasarkan…”

Section: Pendahuluanunclassified

Ekstrak Etanol Ubi Jalar Ungu (Ipomoea Batatas L.) Menurunkan Degenerasi Lemak Jaringan Hati Tikus Yang Di Ovariektomi

Paramita¹,

Sugiritama²,

Linawati³

2019

eum

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Menopause didefinisikan sebagai 1 tahun tanpa menstruasi. Wanita menopause kemungkinan berisiko mengalami Nonalcoholic Fatty Liver Disease(NAFLD). Efek menguntungkan dari antosianin telah dibuktikan dalam penelitian hewan,sehubungan dengan stres oksidatif dan steatosis hati. Ubi jalar ungu mengandung antosianin yang berfungsi sebagai antioksidan. Penelitian ini dilakukan dengan menggunakan sampel tikus yang sudah di ovariektomi, kemudian diberikan ekstrak etanol ubi jalar ungu pada tikus secara oral selama 30 hari. Pada hari pertama dilakukan randomisasi dibagi menjadi empat kelompok yaitu kelompok kontrol negatif (P0), kelompok perlakuan pemberian ekstrak etanol ubi jalar ungu dosis 1ml (P1), dosis 2 ml (P2), dan dosis 4ml (P3). Pada hari ke-31 dilakukan terminasi untuk di ambil jaringan hati dan pembuatan preparat histologi, kemudian dilakukan pengamatan pada preparat dengan pembesaran 10x10 pada 2 lapang pandang. Dari 28 sampel hati tikus yang diperiksa, didapatkan semua sel hati tikus mengalami degenerasi lemak atau steatosis sebanyak >5% yang merupakan kunci dari penyakit hati berlemak nonalkohol (NAFLD), namun jumlahnya berbeda-beda. Rerata perlemakan kelompok kontrol negatif didapatkan hasil perlemakan paling tinggi yaitu 49,1%, kelompok perlakuan pemberian dosis 1ml, 2ml, dan 4ml didapatkan hasil 39,48%, 31,62%, dan 29,14%. Setelah diuji secara statistik didapatkan perbedaan yang signifikan (p<0,05) terhadap pengaruh pemberian ekstrak etanol ubi jalar ungu.Berdasarkan hasil penelitian yang telah dilakukan, maka dapat disimpulkan bahwa pemberianekstrak etanol ubi jalar ungu selama 30 hari dapat menurunkan degenerasi lemak pada hati tikus yang mengalami penyakit hati berlemak nonalkohol (NAFLD). Kata Kunci: Ekstrak etanol ubi jalar ungu, menopause, fatty liver

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Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency

Abstract: Exogenous melatonin protects the liver of OVX rats against steatosis and cellular oxidative stress, possibly via activation of antioxidant enzymes related to glutathione metabolism and by a direct radical scavenging activity.

Cited by 24 publications

References 56 publications

The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats

The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats

Effects of Melatonin on Liver Injuries and Diseases

Ekstrak Etanol Ubi Jalar Ungu (Ipomoea Batatas L.) Menurunkan Degenerasi Lemak Jaringan Hati Tikus Yang Di Ovariektomi

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